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Protein

Actin-related protein 2/3 complex subunit 5

Gene

arc5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:arc5
Synonyms:arc16
ORF Names:SPAC17G8.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17G8.04c.
PomBaseiSPAC17G8.04c. arc5.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • actomyosin contractile ring Source: PomBase
  • Arp2/3 protein complex Source: PomBase
  • cytosol Source: PomBase
  • mating projection tip Source: PomBase
  • medial cortex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Actin-related protein 2/3 complex subunit 5PRO_0000124058Add
BLAST

Proteomic databases

MaxQBiQ10316.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.1 Publication

Protein-protein interaction databases

BioGridi278744. 2 interactions.
IntActiQ10316. 4 interactions.
MINTiMINT-4698678.

Structurei

Secondary structure

1
152
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 384
Helixi40 – 489
Turni57 – 604
Helixi70 – 8516
Helixi89 – 913
Helixi92 – 987
Helixi101 – 11212
Helixi125 – 13511
Helixi142 – 1454

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78G/L1-152[»]
ProteinModelPortaliQ10316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10316.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

InParanoidiQ10316.
KOiK05754.
OMAiCNSMENI.
OrthoDBiEOG092C4ZPD.
PhylomeDBiQ10316.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRTLDVDS ITEPVLTEQD IFPIRNETAE QVQAAVSQLI PQARSAIQTG
60 70 80 90 100
NALQGLKTLL SYVPYGNDVQ EVRTQYLNAF VDVLSNIRAA DIPAFVKECS
110 120 130 140 150
TEEIDNIVNF IYRGLANPQA YNSSVLLNWH EKVVEISGIG CIVRVLNSRP

DL
Length:152
Mass (Da):16,910
Last modified:October 1, 1996 - v1
Checksum:iC892291720BA6161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93687.1.
PIRiT37856.
RefSeqiNP_593727.1. NM_001019158.2.

Genome annotation databases

EnsemblFungiiSPAC17G8.04c.1; SPAC17G8.04c.1:pep; SPAC17G8.04c.
GeneIDi2542275.
KEGGispo:SPAC17G8.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93687.1.
PIRiT37856.
RefSeqiNP_593727.1. NM_001019158.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78G/L1-152[»]
ProteinModelPortaliQ10316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278744. 2 interactions.
IntActiQ10316. 4 interactions.
MINTiMINT-4698678.

Proteomic databases

MaxQBiQ10316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17G8.04c.1; SPAC17G8.04c.1:pep; SPAC17G8.04c.
GeneIDi2542275.
KEGGispo:SPAC17G8.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC17G8.04c.
PomBaseiSPAC17G8.04c. arc5.

Phylogenomic databases

InParanoidiQ10316.
KOiK05754.
OMAiCNSMENI.
OrthoDBiEOG092C4ZPD.
PhylomeDBiQ10316.

Miscellaneous databases

EvolutionaryTraceiQ10316.
PROiQ10316.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC5_SCHPO
AccessioniPrimary (citable) accession number: Q10316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.