Reviewed, UniProtKB/Swiss-Prot Q10309 (YD56_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative phospholipid-transporting ATPase C6C3.06c
    EC=3.6.3.1

Gene names

ORF Names:

SPAC6C3.06c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	1033 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Traceable author statement. Source: GeneDB_SPombe phospholipid transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from direct assay. Source: GeneDB_SPombe integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1033	1033	Putative phospholipid-transporting ATPase C6C3.06c		PRO_0000046319
Regions
	Transmembrane	133 – 153	21	Potential
	Transmembrane	274 – 294	21	Potential
	Transmembrane	317 – 337	21	Potential
	Transmembrane	344 – 364	21	Potential
	Transmembrane	768 – 788	21	Potential
	Transmembrane	843 – 863	21	Potential
	Transmembrane	913 – 933	21	Potential
	Transmembrane	939 – 959	21	Potential
	Transmembrane	965 – 985	21	Potential
	Transmembrane	992 – 1012	21	Potential
Sites
	Active site	408	1	4-aspartylphosphate intermediate By similarity
	Metal binding	770	1	Magnesium By similarity
	Metal binding	774	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q10309-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D57C467427D0C6D6	FASTA	1,033	116,588
	10 20 30 40 50 60 MDSRLNRIQS KMKLWIKDKN LSNPSIPLKV LNKSFRSSRQ SSVSNGHGLY SLDRDETESL 70 80 90 100 110 120 MSSHEASNAG ISLDSSFRVI QVGQPEPQYG NNAVTNTKYD LFTFLPKCLY EQFRYFYNMY 130 140 150 160 170 180 FLLVSLSQLI PPLKIGYLST YIAPLIFVLL ITLTKEAVDD LKRRRRDSYA NNEIYTVNDS 190 200 210 220 230 240 PCAAQNIQAG DVVYIAKDQR IPADMILLET TVGNEAFIRT DQLDGETDWK LRIPCSNQHT 250 260 270 280 290 300 EGIVHADAPI KSVHHFYGTF TLNNQKRPIS VDHTLWANTV LASDGVYGVV VYTGKDTRQS 310 320 330 340 350 360 MNSSKAKTKV GLLEKEINFY SKILCTFVLV LSIGLTFSHG IKTDWYISVF RYLILFSSII 370 380 390 400 410 420 PINLRVNLDL AKIVHSKNTE SDPNLPGVVV RSSNIPEELG RIEYVLTDKT GTLTQNEMEM 430 440 450 460 470 480 KKLHVGTMGF SAESMDVVQA CIQNYSTPIP LSEDSKTLVR NLVLALSLCH NVTPSKGHDG 490 500 510 520 530 540 VVSYQAASPD EVAIVKWTST LGLVLTNRTR DAITLNNNVY KILNIFPFKS ETKRMGIIVQ 550 560 570 580 590 600 SPDEKITFYL KGADSIMQNF VKPSFWLEEE CGNLAREGLR TLVVAKKDLS AEEYSAFSLA 610 620 630 640 650 660 HSDASLSFSN SRDKKMEEIV SRYLENDMDL LGLTGVEDKL QKDVKITLEL LRNAGIHVWM 670 680 690 700 710 720 LTGDKVETAR CIAISSRLVS RGQYIHTINQ LSSREEAHNH LLTLRNKPDS CLIIDGESME 730 740 750 760 770 780 FCIGYLQNEF IDIVSDLSSV VICRCTPTQK ANMTRLIQEK KQASVCCIGD GGNDVGMIQV 790 800 810 820 830 840 ANVGIGIVGK EGQQASLAAD YSVKEFSHVS RLLLWHGRIS YKQTSKLAMF VIHRGLLISV 850 860 870 880 890 900 CQVVYSVISA FEPIALFQGL LLVGYSTMYT MLPVFSIVYD RDVSEKLVFL FPELYKEMRE 910 920 930 940 950 960 QKCFSYKNFI SCVLISVYQG LIIQLFTFYL IGFEEEGKML AVCFSCLIFN ELIMVALQIN 970 980 990 1000 1010 1020 TWEQTIVMSE LLTLMMYILS VPFLTNYFEL KFLLGLKFYW VSALILFISL LPVWCGKALK 1030 RKLKPSSYAK LQR

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAA93618.1.
PIR	T39030.
RefSeq	NP_593720.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2542915.
KEGG	spo:SPAC6C3.06c.
NMPDR	fig|4896.1.peg.3690.
Organism-specific databases
GeneDB_Spombe	SPAC6C3.06c.
Phylogenomic databases
OMA	Q10309. IPDIRIG.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001383-MON.
BRENDA	3.6.3.1. 653.
Gene expression databases
ArrayExpress	Q10309.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR006539. ATPase_P-typ_Plipid-transl. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YD56_SCHPO

Accession

Primary (citable) accession number: Q10309

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)