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Reviewed, UniProtKB/Swiss-Prot Q10303 (ALP21_SCHPO)

Last modified November 24, 2009. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cell polarity protein alp21
Alternative name(s):
    Altered polarity protein 21
    Suppressor of tsm one protein 1
Gene names
Name: alp21
Synonyms: sto1
ORF Names: SPAC22H10.10
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Required for microtubule and spindle assembly. Involved in the proper folding of alpha-tubulin. Ref.2

Subunit structure

Interacts with alp1 and alp11. Ref.1

Subcellular location

Cytoplasm › cytoskeleton.

Sequence similarities

Contains 10 LRR (leucine-rich) repeats.

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Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   DomainLeucine-rich repeat
Repeat
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein folding Ref.2

Traceable author statement. Source: GeneDB_SPombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_SPombe

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functionalpha-tubulin binding Ref.1

Inferred from physical interaction. Source: GeneDB_SPombe

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Cell polarity protein alp21
PRO_0000064569

Regions

Repeat114 – 13825LRR 1
Repeat140 – 16425LRR 2
Repeat166 – 18823LRR 3
Repeat189 – 21628LRR 4
Repeat217 – 24024LRR 5
Repeat241 – 26222LRR 6
Repeat263 – 28826LRR 7
Repeat289 – 30517LRR 8
Repeat306 – 33631LRR 9
Repeat337 – 35418LRR 10

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Sequences

Sequence LengthMass (Da)Tools
Q10303-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: B6FD84864AD648B6

FASTA51158,591
        10         20         30         40         50         60 
MHISTGMVRA SISNTLVTLT IEGNNDRYQV ILDKNVNAKQ FVKTCWRNKK PLIVKEGKIF 

        70         80         90        100        110        120 
VDKGFPFDPC RTFLEALYEK YSYSSPLPSS VEFKSGKQVE FCGFEKIQSK QRDLKSLRVI 

       130        140        150        160        170        180 
ILDNYRIEDI EIEYEYSKIL PEVIDLDLSR NLFHEFFPIL KLCSQLPSLR NLTLDSNLFS 

       190        200        210        220        230        240 
NFISSNTVLL IPHLTQLSVN GCGLNSKDVQ WITETFPSLE VLYLEANEII LSKATSFKNL 

       250        260        270        280        290        300 
QFLQTLSLAN NLNLYSADGY AVDVFQGINN LNLSSTSLAD VAELPVHTLH KLTFLDISEN 

       310        320        330        340        350        360 
NIRDIRSLDH LRTLENLKHL RITLSYFNKP TDIAKLLVIA RIPSLVKLND VNISPNERLD 

       370        380        390        400        410        420 
AELYYTSCIR KLVIDNEIKD VEELTKIEPF WEEIWKSHEL PSIQFHLEAS INDWTSGILK 

       430        440        450        460        470        480 
NRITKGIKIS SINSGATMLL KLHYNWKLLD IKALISYHFA IPVHTSTFVF ASSERDVSFS 

       490        500        510 
PKTVRDDQKR LFELPFTCTF IDVYAKESGN V

« Hide

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References

« Hide 'large scale' references
[1]"Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast."
Radcliffe P.A., Hirata D., Vardy L., Toda T.
Mol. Biol. Cell 10:2987-3001(1999) [PubMed: 10473641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DOMAINS LEUCINE-RICH REPEATS, INTERACTION WITH ALP1 AND ALP11.
[2]"Sto1p, a fission yeast protein similar to tubulin folding cofactor E, plays an essential role in mitotic microtubule assembly."
Grishchuk E.L., McIntosh J.R.
J. Cell Sci. 112:1979-1988(1999) [PubMed: 10341216] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

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Cross-references

Sequence databases

AB008749 Genomic DNA. Translation: BAA23374.1.
CU329670 Genomic DNA. Translation: CAA93613.1.
PIRT43282.
RefSeqNP_593747.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ10303.

Genome annotation databases

GeneID2541847.
GenomeReviewsGene locus alp21 in contig CU329670_GR.
KEGGspo:SPAC22H10.10.
NMPDRfig|4896.1.peg.3717.

Organism-specific databases

GeneDB_SpombeSPAC22H10.10.

Phylogenomic databases

OrthoDBEOG9NZW9C

Gene expression databases

ArrayExpressQ10303.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALP21_SCHPO
AccessionPrimary (citable) accession number: Q10303
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 24, 2009
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents