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Protein

mRNA cleavage and polyadenylation factor clp1

Gene

clp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.UniRule annotation

Caution

May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11ATPUniRule annotation1
Binding sitei49ATP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 121ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA cleavage and polyadenylation factor clp1UniRule annotation
Gene namesi
Name:clp1
ORF Names:SPAC22H10.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22H10.05c
PomBaseiSPAC22H10.05c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001165791 – 456mRNA cleavage and polyadenylation factor clp1Add BLAST456

Proteomic databases

MaxQBiQ10299
PaxDbiQ10299
PRIDEiQ10299

PTM databases

iPTMnetiQ10299

Interactioni

Subunit structurei

Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.UniRule annotation

Protein-protein interaction databases

BioGridi278397, 1 interactor
STRINGi4896.SPAC22H10.05c.1

Structurei

3D structure databases

ProteinModelPortaliQ10299
SMRiQ10299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Clp1 family. Clp1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000231935
KOiK14399
OMAiKVAIFTY
OrthoDBiEOG092C2S2R
PhylomeDBiQ10299

Family and domain databases

Gene3Di2.60.120.1030, 1 hit
3.30.70.2410, 1 hit
HAMAPiMF_03035 Clp1, 1 hit
InterProiView protein in InterPro
IPR028606 Clp1
IPR010655 Clp1_C
IPR038238 Clp1_C_sf
IPR032324 Clp1_N
IPR038239 Clp1_N_sf
IPR032319 CLP1_P
PfamiView protein in Pfam
PF06807 Clp1, 1 hit
PF16573 CLP1_N, 1 hit
PF16575 CLP1_P, 1 hit

Sequencei

Sequence statusi: Complete.

Q10299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEIFIPKEC EWRFEVDEPA IQIRLVSGNA EYFGTELALG PPYHFTRVKG
60 70 80 90 100
AIYTWQGCTL EVEGEPSVEY VAEETPMSTY LNLHFALEGL RLQAENAAAN
110 120 130 140 150
DESSYGPCVC LIGPRSCGKT SVLKILESYA LKQSRHPICV NLDPTQPMLA
160 170 180 190 200
LPGSISAFHN ATILDIQDAD GFGASTSTGP THVLAKVPLV YNFGLDSPLD
210 220 230 240 250
NPKLYKLSLS RLALAVHSRM SQSKDARVSG CLVDTSSIQE NAEKYQDILH
260 270 280 290 300
SIITDFRINI IIVLGSERLY SSMKRKYADA TWLSVVKVSS SGGCIDREEE
310 320 330 340 350
WIQQFQARCI KQYFYGDDRM PLSPLSMIVD STQLVVYRVL EASESGPKSS
360 370 380 390 400
VLPLGFEEEN TQSEKQDGNT SLRLHGKGEF LERISTEAMT ILQNSILAVS
410 420 430 440 450
SVGEDEDEAT VVDSCIIGYV FVSDVDDVKN RMTLLSPVPE QLPSNALIMG

TCKWQE
Length:456
Mass (Da):50,449
Last modified:October 1, 1996 - v1
Checksum:iBBBCDD62EA48E9DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93606.1
PIRiT38207
RefSeqiNP_593741.1, NM_001019172.2

Genome annotation databases

EnsemblFungiiSPAC22H10.05c.1; SPAC22H10.05c.1:pep; SPAC22H10.05c
GeneIDi2541907
KEGGispo:SPAC22H10.05c

Similar proteinsi

Entry informationi

Entry nameiCLP1_SCHPO
AccessioniPrimary (citable) accession number: Q10299
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health