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Protein

mRNA cleavage and polyadenylation factor clp1

Gene

clp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATPUniRule annotation
Binding sitei49 – 491ATP; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi116 – 1216ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. polynucleotide 5'-hydroxyl-kinase activity Source: GO_Central

GO - Biological processi

  1. mRNA 3'-end processing Source: PomBase
  2. mRNA cleavage Source: PomBase
  3. mRNA polyadenylation Source: PomBase
  4. phosphorylation Source: GOC
  5. tRNA splicing, via endonucleolytic cleavage and ligation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA cleavage and polyadenylation factor clp1UniRule annotation
Gene namesi
Name:clp1
ORF Names:SPAC22H10.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC22H10.05c.

Subcellular locationi

Nucleus 1 PublicationUniRule annotation. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mRNA cleavage factor complex Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456mRNA cleavage and polyadenylation factor clp1PRO_0000116579Add
BLAST

Proteomic databases

MaxQBiQ10299.

Interactioni

Subunit structurei

Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.UniRule annotation

Protein-protein interaction databases

BioGridi278397. 1 interaction.
MINTiMINT-4698541.
STRINGi4896.SPAC22H10.05c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Clp1 family. Clp1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG5623.
HOGENOMiHOG000231935.
KOiK14399.
OMAiWHGCELE.
OrthoDBiEOG789CM7.
PhylomeDBiQ10299.

Family and domain databases

HAMAPiMF_03035. Clp1.
InterProiIPR028606. Clp1.
IPR029007. MobB-typ_P-loop.
IPR010655. Pre-mRNA_cleavage_cplxII_Clp1.
[Graphical view]
PfamiPF06807. Clp1. 1 hit.
PF03205. MobB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEIFIPKEC EWRFEVDEPA IQIRLVSGNA EYFGTELALG PPYHFTRVKG
60 70 80 90 100
AIYTWQGCTL EVEGEPSVEY VAEETPMSTY LNLHFALEGL RLQAENAAAN
110 120 130 140 150
DESSYGPCVC LIGPRSCGKT SVLKILESYA LKQSRHPICV NLDPTQPMLA
160 170 180 190 200
LPGSISAFHN ATILDIQDAD GFGASTSTGP THVLAKVPLV YNFGLDSPLD
210 220 230 240 250
NPKLYKLSLS RLALAVHSRM SQSKDARVSG CLVDTSSIQE NAEKYQDILH
260 270 280 290 300
SIITDFRINI IIVLGSERLY SSMKRKYADA TWLSVVKVSS SGGCIDREEE
310 320 330 340 350
WIQQFQARCI KQYFYGDDRM PLSPLSMIVD STQLVVYRVL EASESGPKSS
360 370 380 390 400
VLPLGFEEEN TQSEKQDGNT SLRLHGKGEF LERISTEAMT ILQNSILAVS
410 420 430 440 450
SVGEDEDEAT VVDSCIIGYV FVSDVDDVKN RMTLLSPVPE QLPSNALIMG

TCKWQE
Length:456
Mass (Da):50,449
Last modified:October 1, 1996 - v1
Checksum:iBBBCDD62EA48E9DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93606.1.
PIRiT38207.
RefSeqiNP_593741.1. NM_001019172.2.

Genome annotation databases

EnsemblFungiiSPAC22H10.05c.1; SPAC22H10.05c.1:pep; SPAC22H10.05c.
GeneIDi2541907.
KEGGispo:SPAC22H10.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93606.1.
PIRiT38207.
RefSeqiNP_593741.1. NM_001019172.2.

3D structure databases

ProteinModelPortaliQ10299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278397. 1 interaction.
MINTiMINT-4698541.
STRINGi4896.SPAC22H10.05c-1.

Proteomic databases

MaxQBiQ10299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22H10.05c.1; SPAC22H10.05c.1:pep; SPAC22H10.05c.
GeneIDi2541907.
KEGGispo:SPAC22H10.05c.

Organism-specific databases

PomBaseiSPAC22H10.05c.

Phylogenomic databases

eggNOGiCOG5623.
HOGENOMiHOG000231935.
KOiK14399.
OMAiWHGCELE.
OrthoDBiEOG789CM7.
PhylomeDBiQ10299.

Miscellaneous databases

NextBioi20802994.
PROiQ10299.

Family and domain databases

HAMAPiMF_03035. Clp1.
InterProiIPR028606. Clp1.
IPR029007. MobB-typ_P-loop.
IPR010655. Pre-mRNA_cleavage_cplxII_Clp1.
[Graphical view]
PfamiPF06807. Clp1. 1 hit.
PF03205. MobB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLP1_SCHPO
AccessioniPrimary (citable) accession number: Q10299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.