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Q10299

- CLP1_SCHPO

UniProt

Q10299 - CLP1_SCHPO

Protein

mRNA cleavage and polyadenylation factor clp1

Gene

clp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111ATPUniRule annotation
    Binding sitei49 – 491ATP; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi116 – 1216ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA 3'-end processing Source: PomBase
    2. mRNA cleavage Source: PomBase
    3. mRNA polyadenylation Source: PomBase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA cleavage and polyadenylation factor clp1UniRule annotation
    Gene namesi
    Name:clp1
    ORF Names:SPAC22H10.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC22H10.05c.

    Subcellular locationi

    Nucleus 1 PublicationUniRule annotation. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mRNA cleavage factor complex Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456mRNA cleavage and polyadenylation factor clp1PRO_0000116579Add
    BLAST

    Proteomic databases

    MaxQBiQ10299.

    Interactioni

    Subunit structurei

    Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.UniRule annotation

    Protein-protein interaction databases

    MINTiMINT-4698541.
    STRINGi4896.SPAC22H10.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Clp1 family. Clp1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5623.
    HOGENOMiHOG000231935.
    KOiK14399.
    OMAiWHGCELE.
    OrthoDBiEOG789CM7.
    PhylomeDBiQ10299.

    Family and domain databases

    HAMAPiMF_03035. Clp1.
    InterProiIPR028606. Clp1.
    IPR029007. MobB-typ_P-loop.
    IPR010655. Pre-mRNA_cleavage_cplxII_Clp1.
    [Graphical view]
    PfamiPF06807. Clp1. 1 hit.
    PF03205. MobB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEIFIPKEC EWRFEVDEPA IQIRLVSGNA EYFGTELALG PPYHFTRVKG    50
    AIYTWQGCTL EVEGEPSVEY VAEETPMSTY LNLHFALEGL RLQAENAAAN 100
    DESSYGPCVC LIGPRSCGKT SVLKILESYA LKQSRHPICV NLDPTQPMLA 150
    LPGSISAFHN ATILDIQDAD GFGASTSTGP THVLAKVPLV YNFGLDSPLD 200
    NPKLYKLSLS RLALAVHSRM SQSKDARVSG CLVDTSSIQE NAEKYQDILH 250
    SIITDFRINI IIVLGSERLY SSMKRKYADA TWLSVVKVSS SGGCIDREEE 300
    WIQQFQARCI KQYFYGDDRM PLSPLSMIVD STQLVVYRVL EASESGPKSS 350
    VLPLGFEEEN TQSEKQDGNT SLRLHGKGEF LERISTEAMT ILQNSILAVS 400
    SVGEDEDEAT VVDSCIIGYV FVSDVDDVKN RMTLLSPVPE QLPSNALIMG 450
    TCKWQE 456
    Length:456
    Mass (Da):50,449
    Last modified:October 1, 1996 - v1
    Checksum:iBBBCDD62EA48E9DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93606.1.
    PIRiT38207.
    RefSeqiNP_593741.1. NM_001019172.2.

    Genome annotation databases

    EnsemblFungiiSPAC22H10.05c.1; SPAC22H10.05c.1:pep; SPAC22H10.05c.
    GeneIDi2541907.
    KEGGispo:SPAC22H10.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93606.1 .
    PIRi T38207.
    RefSeqi NP_593741.1. NM_001019172.2.

    3D structure databases

    ProteinModelPortali Q10299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4698541.
    STRINGi 4896.SPAC22H10.05c-1.

    Proteomic databases

    MaxQBi Q10299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC22H10.05c.1 ; SPAC22H10.05c.1:pep ; SPAC22H10.05c .
    GeneIDi 2541907.
    KEGGi spo:SPAC22H10.05c.

    Organism-specific databases

    PomBasei SPAC22H10.05c.

    Phylogenomic databases

    eggNOGi COG5623.
    HOGENOMi HOG000231935.
    KOi K14399.
    OMAi WHGCELE.
    OrthoDBi EOG789CM7.
    PhylomeDBi Q10299.

    Miscellaneous databases

    NextBioi 20802994.
    PROi Q10299.

    Family and domain databases

    HAMAPi MF_03035. Clp1.
    InterProi IPR028606. Clp1.
    IPR029007. MobB-typ_P-loop.
    IPR010655. Pre-mRNA_cleavage_cplxII_Clp1.
    [Graphical view ]
    Pfami PF06807. Clp1. 1 hit.
    PF03205. MobB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLP1_SCHPO
    AccessioniPrimary (citable) accession number: Q10299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3