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Q10299 (CLP1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
mRNA cleavage and polyadenylation factor clp1
Gene names
Name:clp1
ORF Names:SPAC22H10.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation By similarity. HAMAP-Rule MF_03035

Subunit structure

Component of a pre-mRNA cleavage factor complex By similarity. Interacts directly with PCF11 By similarity.

Subcellular location

Nucleus. Cytoplasm Ref.2.

Sequence similarities

Belongs to the Clp1 family. Clp1 subfamily.

Caution

May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA 3'-end processing

Inferred from sequence orthology. Source: PomBase

mRNA cleavage

Inferred from sequence orthology. Source: PomBase

mRNA polyadenylation

Inferred from sequence orthology. Source: PomBase

   Cellular_componentcytosol

Inferred from direct assay Ref.2. Source: PomBase

mRNA cleavage factor complex

Inferred from sequence orthology. Source: PomBase

nucleus

Inferred from direct assay Ref.2. Source: PomBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456mRNA cleavage and polyadenylation factor clp1 HAMAP-Rule MF_03035
PRO_0000116579

Regions

Nucleotide binding116 – 1216ATP By similarity

Sites

Binding site111ATP By similarity
Binding site491ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10299 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: BBBCDD62EA48E9DF

FASTA45650,449
        10         20         30         40         50         60 
MKEIFIPKEC EWRFEVDEPA IQIRLVSGNA EYFGTELALG PPYHFTRVKG AIYTWQGCTL 

        70         80         90        100        110        120 
EVEGEPSVEY VAEETPMSTY LNLHFALEGL RLQAENAAAN DESSYGPCVC LIGPRSCGKT 

       130        140        150        160        170        180 
SVLKILESYA LKQSRHPICV NLDPTQPMLA LPGSISAFHN ATILDIQDAD GFGASTSTGP 

       190        200        210        220        230        240 
THVLAKVPLV YNFGLDSPLD NPKLYKLSLS RLALAVHSRM SQSKDARVSG CLVDTSSIQE 

       250        260        270        280        290        300 
NAEKYQDILH SIITDFRINI IIVLGSERLY SSMKRKYADA TWLSVVKVSS SGGCIDREEE 

       310        320        330        340        350        360 
WIQQFQARCI KQYFYGDDRM PLSPLSMIVD STQLVVYRVL EASESGPKSS VLPLGFEEEN 

       370        380        390        400        410        420 
TQSEKQDGNT SLRLHGKGEF LERISTEAMT ILQNSILAVS SVGEDEDEAT VVDSCIIGYV 

       430        440        450 
FVSDVDDVKN RMTLLSPVPE QLPSNALIMG TCKWQE 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA93606.1.
PIRT38207.
RefSeqNP_593741.1. NM_001019172.2.

3D structure databases

ProteinModelPortalQ10299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4698541.
STRING4896.SPAC22H10.05c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC22H10.05c.1; SPAC22H10.05c.1:pep; SPAC22H10.05c.
GeneID2541907.
KEGGspo:SPAC22H10.05c.

Organism-specific databases

PomBaseSPAC22H10.05c.

Phylogenomic databases

eggNOGCOG5623.
HOGENOMHOG000231935.
KOK14399.
OMAQGPRVIV.
OrthoDBEOG789CM7.
PhylomeDBQ10299.

Family and domain databases

HAMAPMF_03035. Clp1.
InterProIPR028606. Clp1.
IPR010655. Pre-mRNA_cleavage_cplxII_Clp1.
[Graphical view]
PfamPF06807. Clp1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802994.
PROQ10299.

Entry information

Entry nameCLP1_SCHPO
AccessionPrimary (citable) accession number: Q10299
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names