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Q10298

- YD44_SCHPO

UniProt

Q10298 - YD44_SCHPO

Protein

Putative serine/threonine-protein phosphatase C22H10.04

Gene

SPAC22H10.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511Manganese 1By similarity
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi79 – 791Manganese 1By similarity
    Metal bindingi79 – 791Manganese 2By similarity
    Metal bindingi111 – 1111Manganese 2By similarity
    Active sitei112 – 1121Proton donorBy similarity
    Metal bindingi161 – 1611Manganese 2By similarity
    Metal bindingi236 – 2361Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: PomBase
    3. protein serine/threonine phosphatase activity Source: PomBase

    GO - Biological processi

    1. asymmetric protein localization to old mitotic spindle pole body Source: PomBase
    2. negative regulation of septation initiation signaling Source: PomBase
    3. protein dephosphorylation Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein phosphatase C22H10.04 (EC:3.1.3.16)
    Gene namesi
    ORF Names:SPAC22H10.04
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC22H10.04.

    Subcellular locationi

    GO - Cellular componenti

    1. FAR/SIN/STRIPAK complex Source: PomBase
    2. mitotic spindle pole body Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Putative serine/threonine-protein phosphatase C22H10.04PRO_0000058918Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi277949. 5 interactions.
    STRINGi4896.SPAC22H10.04-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10298.
    SMRiQ10298. Positions 1-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-X subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    KOiK17615.
    OMAiFYTECVR.
    OrthoDBiEOG7FFN29.
    PhylomeDBiQ10298.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDLDNIIER LYEKQLIAES VIAYLCSLAK EVLMQESNVV RLSTPITVVG    50
    DIHGQFDDLL EIFRIGGPCP YTNYLFLGDY VDRGYYSIET ITLLICLKLR 100
    YPKRITLLRG NHESRGITQT YGFYSECLRK YGNANVWKYF TDIFDFLTLS 150
    ATIDDTIFCV HGGLSPSIQH IDQILVLDRF REFPHEGPMA DLVWSDPDPS 200
    VQEFSLSPRG AGFSFGEVIV TKFLEYNNMK HILRAHQLCS EGYQILFEKK 250
    LSTVWSAPNY CYRCANLASI LQIDTDQSRF FNVFDAAPNQ ETPFVEPAAK 300
    VTAEYFL 307
    Length:307
    Mass (Da):35,178
    Last modified:October 1, 1996 - v1
    Checksum:iA13E8B591B7D731F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93605.1.
    PIRiT38206.
    RefSeqiNP_593740.1. NM_001019171.2.

    Genome annotation databases

    EnsemblFungiiSPAC22H10.04.1; SPAC22H10.04.1:pep; SPAC22H10.04.
    GeneIDi2541444.
    KEGGispo:SPAC22H10.04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93605.1 .
    PIRi T38206.
    RefSeqi NP_593740.1. NM_001019171.2.

    3D structure databases

    ProteinModelPortali Q10298.
    SMRi Q10298. Positions 1-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277949. 5 interactions.
    STRINGi 4896.SPAC22H10.04-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC22H10.04.1 ; SPAC22H10.04.1:pep ; SPAC22H10.04 .
    GeneIDi 2541444.
    KEGGi spo:SPAC22H10.04.

    Organism-specific databases

    PomBasei SPAC22H10.04.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    KOi K17615.
    OMAi FYTECVR.
    OrthoDBi EOG7FFN29.
    PhylomeDBi Q10298.

    Miscellaneous databases

    NextBioi 20802546.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiYD44_SCHPO
    AccessioniPrimary (citable) accession number: Q10298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3