Reviewed,
UniProtKB/Swiss-Prot Q10295 (PAP_SCHPO)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Poly(A) polymerase pla1 Short name=PAP EC=2.7.7.19 Alternative name(s): Polynucleotide adenylyltransferase | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 566 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I). Ref.1 |
| Catalytic activity | ATP + RNA(n) = diphosphate + RNA(n+1). |
| Subcellular location | |
| Sequence similarities | Belongs to the poly(A) polymerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing |
| Cellular component | Nucleus |
| Ligand | ATP-binding Nucleotide-binding RNA-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | mRNA polyadenylation Ref.1 Inferred from genetic interaction. Source: GeneDB_SPombe transcriptionInferred from electronic annotation. Source: InterPro |
| Cellular component | mRNA cleavage and polyadenylation specificity factor complex Ref.1 Inferred from genetic interaction. Source: GeneDB_SPombe |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA bindingInferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Ref.1Inferred from genetic interaction. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Schizosaccharomyces pombe pla1 gene encodes a poly(A) polymerase and can functionally replace its Saccharomyces cerevisiae homologue." Ohnacker M., Minivielle-Sebastia L., Keller W. Nucleic Acids Res. 24:2585-2591(1996) [PubMed: 8692700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library." Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y. Genes Cells 5:169-190(2000) [PubMed: 10759889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 233-436, SUBCELLULAR LOCATION. Strain: ATCC 38364 / 968. |
Cross-references
Sequence databases | |
|---|---|
| X79705 mRNA. Translation: CAA56141.1. CU329671 Genomic DNA. Translation: CAA22808.1. AB027883 Genomic DNA. Translation: BAA87187.1. | |
| PIR | JC6058. |
| RefSeq | NP_595362.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FA0 based on UniProtKB P29468. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2541099. |
| KEGG | spo:SPBC646.04. |
| NMPDR | fig|4896.1.peg.1228. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC646.04. |
Phylogenomic databases | |
| OMA | Q10295. WSWPQPV. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003438-MON. |
| BRENDA | 2.7.7.19. 653. |
Gene expression databases | |
| ArrayExpress | Q10295. |
Family and domain databases | |
| InterPro | IPR002934. Nucleotidyltransferase. IPR007012. PolA_pol_centr. IPR007010. PolA_pol_RNA-bd. IPR014492. PolyA_polymerase. [Graphical view] |
| Gene3D | G3DSA:3.30.70.590. PolA_pol_RNA-bd. 1 hit. |
| Pfam | PF01909. NTP_transf_2. 1 hit. PF04928. PAP_central. 1 hit. PF04926. PAP_RNA-bind. 1 hit. [Graphical view] |
| PIRSF | PIRSF018425. PolyA_polymerase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PAP_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q10295 Secondary accession number(s): Q9UU09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


