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Protein

Myo-inositol transporter 1

Gene

itr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transporter for myo-inositol.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate import across plasma membrane Source: PomBase
  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 1
Gene namesi
Name:itr1
ORF Names:SPAC4F8.15, SPAC7D4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F8.15.
PomBaseiSPAC4F8.15. itr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini108 – 12922LumenalSequence analysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini151 – 1566CytoplasmicSequence analysis
Transmembranei157 – 17721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini178 – 1869LumenalSequence analysis
Transmembranei187 – 20721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini208 – 2158CytoplasmicSequence analysis
Transmembranei216 – 23621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini237 – 24610LumenalSequence analysis
Transmembranei247 – 26721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini268 – 34982CytoplasmicSequence analysisAdd
BLAST
Transmembranei350 – 37021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini371 – 3766LumenalSequence analysis
Transmembranei377 – 39721Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini398 – 4003CytoplasmicSequence analysis
Transmembranei401 – 42121Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini422 – 44120LumenalSequence analysisAdd
BLAST
Transmembranei442 – 46221Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini463 – 48624CytoplasmicSequence analysisAdd
BLAST
Transmembranei487 – 50721Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini508 – 5103LumenalSequence analysis
Transmembranei511 – 53121Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini532 – 57544CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: PomBase
  • Golgi apparatus Source: PomBase
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Myo-inositol transporter 1PRO_0000050453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ10286.

Interactioni

Protein-protein interaction databases

BioGridi279577. 4 interactions.
MINTiMINT-4698426.

Structurei

3D structure databases

ProteinModelPortaliQ10286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiQ10286.
KOiK08150.
OrthoDBiEOG092C305R.
PhylomeDBiQ10286.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSKDFQN VTSAGFADDT FAADTFAADK KSPFESSVFE NKTQVLPVDS
60 70 80 90 100
VSRLSNGARS RSNSNISLSE PHALNDTVED QPVSKWVWVL AFAAGIGGLL
110 120 130 140 150
FGYDTGVISG ALVVIGTSLG GHELTNGGKE FITSATSLGA LLGGIIAGAL
160 170 180 190 200
ADFFGRKPVI AIASIIIIVG SIVQVTAHHL WHMIVGRFVI GWGVGIASLI
210 220 230 240 250
IPLYLSEIAP SKIRGRLVII YVLLITAGQV IAYGIDTAFE HVHNGWRWMV
260 270 280 290 300
GLAMVPAAFQ LFILIWLPES PRLLVKKERS QEAYNTLARI YPTAHPYEIK
310 320 330 340 350
TKLYLIQEGV RDPFSGSRWQ KIVKTFKELY FNPSNFRALI LACGLQAMQQ
360 370 380 390 400
LSGFNSLMYF SSTIFEVVGF NNPTATGLII AATNFVFTIV AFGVIDFFGR
410 420 430 440 450
RILLLLTVWG MIAALIVCAV AFHFLPKDEN GNYTSGQSNA WAIVVLISMI
460 470 480 490 500
VYVASYASGL GNLPWQQSEL FPMSVRGLGT GMSTAVNWAG NLGIGASFLT
510 520 530 540 550
LMSEITPTGT FALYGGLCFL GWLGALFCYP DLTDYTIEEI GELLKHGFGV
560 570
RESMRHLKRV RQERAWSRED KEQNN
Length:575
Mass (Da):62,758
Last modified:November 1, 1997 - v1
Checksum:i3B7C5EFF86C596AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98622 Genomic DNA. Translation: CAA67211.1.
CU329670 Genomic DNA. Translation: CAB16718.1.
AB027770 Genomic DNA. Translation: BAA87074.1.
PIRiT43400.
RefSeqiNP_593858.2. NM_001019287.2.

Genome annotation databases

EnsemblFungiiSPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15.
GeneIDi2543145.
KEGGispo:SPAC4F8.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98622 Genomic DNA. Translation: CAA67211.1.
CU329670 Genomic DNA. Translation: CAB16718.1.
AB027770 Genomic DNA. Translation: BAA87074.1.
PIRiT43400.
RefSeqiNP_593858.2. NM_001019287.2.

3D structure databases

ProteinModelPortaliQ10286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279577. 4 interactions.
MINTiMINT-4698426.

Proteomic databases

MaxQBiQ10286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15.
GeneIDi2543145.
KEGGispo:SPAC4F8.15.

Organism-specific databases

EuPathDBiFungiDB:SPAC4F8.15.
PomBaseiSPAC4F8.15. itr1.

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiQ10286.
KOiK08150.
OrthoDBiEOG092C305R.
PhylomeDBiQ10286.

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Miscellaneous databases

PROiQ10286.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITR1_SCHPO
AccessioniPrimary (citable) accession number: Q10286
Secondary accession number(s): Q9UU75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.