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Protein

Myo-inositol transporter 1

Gene

itr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transporter for myo-inositol.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate import across plasma membrane Source: PomBase
  • glucose import Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-SPO-429593 Inositol transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 1
Gene namesi
Name:itr1
ORF Names:SPAC4F8.15, SPAC7D4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F8.15
PomBaseiSPAC4F8.15 itr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini108 – 129LumenalSequence analysisAdd BLAST22
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini151 – 156CytoplasmicSequence analysis6
Transmembranei157 – 177Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini178 – 186LumenalSequence analysis9
Transmembranei187 – 207Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini208 – 215CytoplasmicSequence analysis8
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 246LumenalSequence analysis10
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 349CytoplasmicSequence analysisAdd BLAST82
Transmembranei350 – 370Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini371 – 376LumenalSequence analysis6
Transmembranei377 – 397Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini398 – 400CytoplasmicSequence analysis3
Transmembranei401 – 421Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini422 – 441LumenalSequence analysisAdd BLAST20
Transmembranei442 – 462Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini463 – 486CytoplasmicSequence analysisAdd BLAST24
Transmembranei487 – 507Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini508 – 510LumenalSequence analysis3
Transmembranei511 – 531Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini532 – 575CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504531 – 575Myo-inositol transporter 1Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ10286
PaxDbiQ10286
PRIDEiQ10286

PTM databases

iPTMnetiQ10286

Interactioni

Protein-protein interaction databases

BioGridi279577, 4 interactors
STRINGi4896.SPAC4F8.15.1

Structurei

3D structure databases

ProteinModelPortaliQ10286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202868
InParanoidiQ10286
KOiK08150
OMAiSWGVVVW
OrthoDBiEOG092C305R
PhylomeDBiQ10286

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequencei

Sequence statusi: Complete.

Q10286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSKDFQN VTSAGFADDT FAADTFAADK KSPFESSVFE NKTQVLPVDS
60 70 80 90 100
VSRLSNGARS RSNSNISLSE PHALNDTVED QPVSKWVWVL AFAAGIGGLL
110 120 130 140 150
FGYDTGVISG ALVVIGTSLG GHELTNGGKE FITSATSLGA LLGGIIAGAL
160 170 180 190 200
ADFFGRKPVI AIASIIIIVG SIVQVTAHHL WHMIVGRFVI GWGVGIASLI
210 220 230 240 250
IPLYLSEIAP SKIRGRLVII YVLLITAGQV IAYGIDTAFE HVHNGWRWMV
260 270 280 290 300
GLAMVPAAFQ LFILIWLPES PRLLVKKERS QEAYNTLARI YPTAHPYEIK
310 320 330 340 350
TKLYLIQEGV RDPFSGSRWQ KIVKTFKELY FNPSNFRALI LACGLQAMQQ
360 370 380 390 400
LSGFNSLMYF SSTIFEVVGF NNPTATGLII AATNFVFTIV AFGVIDFFGR
410 420 430 440 450
RILLLLTVWG MIAALIVCAV AFHFLPKDEN GNYTSGQSNA WAIVVLISMI
460 470 480 490 500
VYVASYASGL GNLPWQQSEL FPMSVRGLGT GMSTAVNWAG NLGIGASFLT
510 520 530 540 550
LMSEITPTGT FALYGGLCFL GWLGALFCYP DLTDYTIEEI GELLKHGFGV
560 570
RESMRHLKRV RQERAWSRED KEQNN
Length:575
Mass (Da):62,758
Last modified:November 1, 1997 - v1
Checksum:i3B7C5EFF86C596AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98622 Genomic DNA Translation: CAA67211.1
CU329670 Genomic DNA Translation: CAB16718.1
AB027770 Genomic DNA Translation: BAA87074.1
PIRiT43400
RefSeqiNP_593858.2, NM_001019287.2

Genome annotation databases

EnsemblFungiiSPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15
GeneIDi2543145
KEGGispo:SPAC4F8.15

Similar proteinsi

Entry informationi

Entry nameiITR1_SCHPO
AccessioniPrimary (citable) accession number: Q10286
Secondary accession number(s): Q9UU75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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