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Protein

Uracil permease

Gene

fur4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of uracil.

GO - Molecular functioni

  • uracil:cation symporter activity Source: PomBase
  • uracil transmembrane transporter activity Source: PomBase

GO - Biological processi

  • uracil import across plasma membrane Source: PomBase

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.39.3.7 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:fur4
ORF Names:SPAC1399.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1399.03
PomBaseiSPAC1399.03 fur4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979241 – 581Uracil permeaseAdd BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei572Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10279
PaxDbiQ10279
PRIDEiQ10279

PTM databases

iPTMnetiQ10279

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC1399.03.1

Structurei

3D structure databases

ProteinModelPortaliQ10279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202588
InParanoidiQ10279
KOiK03457
OMAiVGLAMCP
OrthoDBiEOG092C1JZY
PhylomeDBiQ10279

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

Q10279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVDNNSFF SRIRNSNAYR KVKDFVILDH RPGMTMAERM LTNKDLYPVP
60 70 80 90 100
PSKRLWGPWN FISFWLADAV NINTWMISAT AIELGLNWWE AWICVWVGYL
110 120 130 140 150
ICGILVATTG RPGAVYHISF PVLSRSSFGT WGSLWPILNR SVLACVWYGV
160 170 180 190 200
QAWIGGECVV LMIRSIWPSF SHIPNTMAKS GTETYQWVGF FIFWLLSNIA
210 220 230 240 250
IWFPVHQIRH LFTFKAIVAP PAAIAFLIWA LVKAHGAGPV IHEPTKLGQY
260 270 280 290 300
EHAWVVINGI VTCIDGFATL IVNNPDFARF ATTPGAVHWP QIITVPLAFG
310 320 330 340 350
VTSLIGVLVS SASKAIYGTT LWDPTQLLAS FLDHSNAHGV RAGVFFIAFG
360 370 380 390 400
LCIAQLGVNI AANSVSAGND LSALLPTVIN VRRGGYIASI IALCMCPWNL
410 420 430 440 450
LSSNNNFTTY LSSYSVFLSS FAGVIIADYY FVRKGLIRVA PLYSSSSSSP
460 470 480 490 500
YYFWKGINFR AFASYICGML INIVGMAGST GQKVPKVANT MFNLNYFLGI
510 520 530 540 550
TVACLSHIII CKIFPVTECG EKMLSEVPEE ADDYLLTLAS EDSIDKDSTS
560 570 580
EIYIDGLPTE KEVEKDDVLS ITSKKLSGCF P
Length:581
Mass (Da):64,177
Last modified:August 14, 2001 - v2
Checksum:iDFBE6F7C5602438F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti573 – 581SKKLSGCFP → RQKIIGLFSLGKLLFVV (PubMed:9730284).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98696 Genomic DNA Translation: CAA67256.1
CU329670 Genomic DNA Translation: CAC19744.1
PIRiT43295
RefSeqiNP_593511.1, NM_001018945.2

Genome annotation databases

EnsemblFungiiSPAC1399.03.1; SPAC1399.03.1:pep; SPAC1399.03
GeneIDi2542586
KEGGispo:SPAC1399.03

Similar proteinsi

Entry informationi

Entry nameiFUR4_SCHPO
AccessioniPrimary (citable) accession number: Q10279
Secondary accession number(s): Q9HE14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health