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Protein

Uracil permease

Gene

fur4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transport of uracil.

GO - Molecular functioni

  • nucleobase transmembrane transporter activity Source: GO_Central
  • uracil:cation symporter activity Source: PomBase
  • uridine transmembrane transporter activity Source: PomBase

GO - Biological processi

  • uracil import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.39.3.7. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:fur4
ORF Names:SPAC1399.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1399.03.
PomBaseiSPAC1399.03. fur4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST
Transmembranei496 – 51621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • fungal-type vacuole Source: PomBase
  • Golgi apparatus Source: PomBase
  • Golgi membrane Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central
  • plasma membrane raft Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Uracil permeasePRO_0000197924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei572 – 5721Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10279.

PTM databases

iPTMnetiQ10279.

Interactioni

Protein-protein interaction databases

MINTiMINT-4698361.

Structurei

3D structure databases

ProteinModelPortaliQ10279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202588.
InParanoidiQ10279.
KOiK03457.
OMAiFTAKAYF.
OrthoDBiEOG75B8F6.
PhylomeDBiQ10279.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVDNNSFF SRIRNSNAYR KVKDFVILDH RPGMTMAERM LTNKDLYPVP
60 70 80 90 100
PSKRLWGPWN FISFWLADAV NINTWMISAT AIELGLNWWE AWICVWVGYL
110 120 130 140 150
ICGILVATTG RPGAVYHISF PVLSRSSFGT WGSLWPILNR SVLACVWYGV
160 170 180 190 200
QAWIGGECVV LMIRSIWPSF SHIPNTMAKS GTETYQWVGF FIFWLLSNIA
210 220 230 240 250
IWFPVHQIRH LFTFKAIVAP PAAIAFLIWA LVKAHGAGPV IHEPTKLGQY
260 270 280 290 300
EHAWVVINGI VTCIDGFATL IVNNPDFARF ATTPGAVHWP QIITVPLAFG
310 320 330 340 350
VTSLIGVLVS SASKAIYGTT LWDPTQLLAS FLDHSNAHGV RAGVFFIAFG
360 370 380 390 400
LCIAQLGVNI AANSVSAGND LSALLPTVIN VRRGGYIASI IALCMCPWNL
410 420 430 440 450
LSSNNNFTTY LSSYSVFLSS FAGVIIADYY FVRKGLIRVA PLYSSSSSSP
460 470 480 490 500
YYFWKGINFR AFASYICGML INIVGMAGST GQKVPKVANT MFNLNYFLGI
510 520 530 540 550
TVACLSHIII CKIFPVTECG EKMLSEVPEE ADDYLLTLAS EDSIDKDSTS
560 570 580
EIYIDGLPTE KEVEKDDVLS ITSKKLSGCF P
Length:581
Mass (Da):64,177
Last modified:August 14, 2001 - v2
Checksum:iDFBE6F7C5602438F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti573 – 5819SKKLSGCFP → RQKIIGLFSLGKLLFVV (PubMed:9730284).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98696 Genomic DNA. Translation: CAA67256.1.
CU329670 Genomic DNA. Translation: CAC19744.1.
PIRiT43295.
RefSeqiNP_593511.1. NM_001018945.2.

Genome annotation databases

EnsemblFungiiSPAC1399.03.1; SPAC1399.03.1:pep; SPAC1399.03.
GeneIDi2542586.
KEGGispo:SPAC1399.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98696 Genomic DNA. Translation: CAA67256.1.
CU329670 Genomic DNA. Translation: CAC19744.1.
PIRiT43295.
RefSeqiNP_593511.1. NM_001018945.2.

3D structure databases

ProteinModelPortaliQ10279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4698361.

Protein family/group databases

TCDBi2.A.39.3.7. the nucleobase:cation symporter-1 (ncs1) family.

PTM databases

iPTMnetiQ10279.

Proteomic databases

MaxQBiQ10279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1399.03.1; SPAC1399.03.1:pep; SPAC1399.03.
GeneIDi2542586.
KEGGispo:SPAC1399.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC1399.03.
PomBaseiSPAC1399.03. fur4.

Phylogenomic databases

HOGENOMiHOG000202588.
InParanoidiQ10279.
KOiK03457.
OMAiFTAKAYF.
OrthoDBiEOG75B8F6.
PhylomeDBiQ10279.

Miscellaneous databases

PROiQ10279.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The uracil permease of Schizosaccharomyces pombe: a representative of a family of 10 transmembrane helix transporter proteins of yeasts."
    de Montigny J., Straub M.L., Wagner R., Bach M.L., Chevallier M.R.
    Yeast 14:1051-1059(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-572, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiFUR4_SCHPO
AccessioniPrimary (citable) accession number: Q10279
Secondary accession number(s): Q9HE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: July 6, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.