Q10276 (KICH_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative choline kinase
EC=2.7.1.32

Gene names

ORF Names:

SPAC13G7.12c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + choline = ADP + phosphocholine.
Pathway	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the choline/ethanolamine kinase family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase nucleus Inferred from direct assay PubMed 16823372. Source: PomBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW choline kinase activity Inferred from sequence orthology. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Putative choline kinase		PRO_0000206225

Sequences

	Sequence		Length	Mass (Da)
	Q10276 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 08284FF1FC5FA089	FASTA	456	52,536
	10 20 30 40 50 60 MVNFASEVDK NNAFDSAHPS RKCKGSLDCN DPDPIFRHKV LVIIHKLAIS SWNRIPLTLC 70 80 90 100 110 120 NKLHIKRISG ALTNAVYYVA PPEGYHAPKL LLRIYGPHVE LFINRQVELE NLKRLARHNI 130 140 150 160 170 180 GPYLIGEFSN GRFEQYMEST TLTCKTIRDP KLSIYVGRRL CELHNFILLH PHEVLEMPAA 190 200 210 220 230 240 WKNCLVWLPK AKAKILGRKH SLAITSEFMK TLEEDFNAYY NWFVEWSRDK KDWFGLKMVF 250 260 270 280 290 300 SHNDTQYGNL LKIKAKKRSI PLSQKHRTLV PVDFEYAGPN LCAFDLANYF AEWMADYHHP 310 320 330 340 350 360 THNYLMDRSR YPDFNARKLV YHAYVEQSAV INDLLEIEDA SLLKTDISDE LKNTFEKQIM 370 380 390 400 410 420 NLEESVRAIS PAANIGWALW GILQCLEEDD EWEDLSVSSQ VADRPEKQLV EGSTVPPIGT 430 440 450 SSFDYIGYSS EKFDLFYEGC AALGLNGRNR STFSYA

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA93600.1.
PIR	S67441.
RefSeq	NP_593714.1. NM_001019145.2.
3D structure databases
ProteinModelPortal	Q10276.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4698336.
STRING	4896.SPAC13G7.12c-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC13G7.12c.1; SPAC13G7.12c.1:pep; SPAC13G7.12c.
GeneID	2542839.
KEGG	spo:SPAC13G7.12c.
Organism-specific databases
PomBase	SPAC13G7.12c.
Phylogenomic databases
eggNOG	COG0510.
KO	K00866.
OMA	ANHFHEW.
OrthoDB	EOG466ZW1.
Enzyme and pathway databases
UniPathway	UPA00753; UER00737.
Family and domain databases
InterPro	IPR026712. Cho/Etha_kinase. IPR007521. Choline_kin_N. IPR011009. Kinase-like_dom. [Graphical view]
PANTHER	PTHR22603. PTHR22603. 1 hit.
Pfam	PF04428. Choline_kin_N. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
ProtoNet	Search...
Other
NextBio	20803880.

Entry information

Entry name

KICH_SCHPO

Accession

Primary (citable) accession number: Q10276

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program