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Q10276

- KICH_SCHPO

UniProt

Q10276 - KICH_SCHPO

Protein

Putative choline kinase

Gene

SPAC13G7.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + choline = ADP + phosphocholine.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. choline kinase activity Source: PomBase

    GO - Biological processi

    1. CDP-choline pathway Source: GOC
    2. phosphatidylcholine biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00753; UER00737.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative choline kinase (EC:2.7.1.32)
    Gene namesi
    ORF Names:SPAC13G7.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC13G7.12c.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Putative choline kinasePRO_0000206225Add
    BLAST

    Proteomic databases

    MaxQBiQ10276.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi279285. 30 interactions.
    MINTiMINT-4698336.
    STRINGi4896.SPAC13G7.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0510.
    KOiK00866.
    OMAiPEHRQII.
    OrthoDBiEOG7WT48T.
    PhylomeDBiQ10276.

    Family and domain databases

    InterProiIPR026712. Cho/Etha_kinase.
    IPR007521. Choline_kin_N.
    IPR011009. Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
    PfamiPF04428. Choline_kin_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q10276-1 [UniParc]FASTAAdd to Basket

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    MVNFASEVDK NNAFDSAHPS RKCKGSLDCN DPDPIFRHKV LVIIHKLAIS    50
    SWNRIPLTLC NKLHIKRISG ALTNAVYYVA PPEGYHAPKL LLRIYGPHVE 100
    LFINRQVELE NLKRLARHNI GPYLIGEFSN GRFEQYMEST TLTCKTIRDP 150
    KLSIYVGRRL CELHNFILLH PHEVLEMPAA WKNCLVWLPK AKAKILGRKH 200
    SLAITSEFMK TLEEDFNAYY NWFVEWSRDK KDWFGLKMVF SHNDTQYGNL 250
    LKIKAKKRSI PLSQKHRTLV PVDFEYAGPN LCAFDLANYF AEWMADYHHP 300
    THNYLMDRSR YPDFNARKLV YHAYVEQSAV INDLLEIEDA SLLKTDISDE 350
    LKNTFEKQIM NLEESVRAIS PAANIGWALW GILQCLEEDD EWEDLSVSSQ 400
    VADRPEKQLV EGSTVPPIGT SSFDYIGYSS EKFDLFYEGC AALGLNGRNR 450
    STFSYA 456
    Length:456
    Mass (Da):52,536
    Last modified:October 1, 1996 - v1
    Checksum:i08284FF1FC5FA089
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93600.1.
    PIRiS67441.
    RefSeqiNP_593714.1. NM_001019145.2.

    Genome annotation databases

    EnsemblFungiiSPAC13G7.12c.1; SPAC13G7.12c.1:pep; SPAC13G7.12c.
    GeneIDi2542839.
    KEGGispo:SPAC13G7.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93600.1 .
    PIRi S67441.
    RefSeqi NP_593714.1. NM_001019145.2.

    3D structure databases

    ProteinModelPortali Q10276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279285. 30 interactions.
    MINTi MINT-4698336.
    STRINGi 4896.SPAC13G7.12c-1.

    Proteomic databases

    MaxQBi Q10276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC13G7.12c.1 ; SPAC13G7.12c.1:pep ; SPAC13G7.12c .
    GeneIDi 2542839.
    KEGGi spo:SPAC13G7.12c.

    Organism-specific databases

    PomBasei SPAC13G7.12c.

    Phylogenomic databases

    eggNOGi COG0510.
    KOi K00866.
    OMAi PEHRQII.
    OrthoDBi EOG7WT48T.
    PhylomeDBi Q10276.

    Enzyme and pathway databases

    UniPathwayi UPA00753 ; UER00737 .

    Miscellaneous databases

    NextBioi 20803880.
    PROi Q10276.

    Family and domain databases

    InterProi IPR026712. Cho/Etha_kinase.
    IPR007521. Choline_kin_N.
    IPR011009. Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR22603:SF32. PTHR22603:SF32. 1 hit.
    Pfami PF04428. Choline_kin_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiKICH_SCHPO
    AccessioniPrimary (citable) accession number: Q10276
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3