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Protein

Putative choline kinase

Gene

SPAC13G7.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_287143. Synthesis of PE.
REACT_297299. Synthesis of PC.
UniPathwayiUPA00753; UER00737.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline kinase (EC:2.7.1.32)
Gene namesi
ORF Names:SPAC13G7.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13G7.12c.
PomBaseiSPAC13G7.12c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Putative choline kinasePRO_0000206225Add
BLAST

Proteomic databases

MaxQBiQ10276.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi279285. 30 interactions.
MINTiMINT-4698336.
STRINGi4896.SPAC13G7.12c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiCOG0510.
InParanoidiQ10276.
KOiK00866.
OMAiFLIRIHC.
OrthoDBiEOG7WT48T.
PhylomeDBiQ10276.

Family and domain databases

InterProiIPR026712. Cho/Etha_kinase.
IPR007521. Choline_kin_N.
IPR011009. Kinase-like_dom.
[Graphical view]
PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
PfamiPF04428. Choline_kin_N. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

Q10276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNFASEVDK NNAFDSAHPS RKCKGSLDCN DPDPIFRHKV LVIIHKLAIS
60 70 80 90 100
SWNRIPLTLC NKLHIKRISG ALTNAVYYVA PPEGYHAPKL LLRIYGPHVE
110 120 130 140 150
LFINRQVELE NLKRLARHNI GPYLIGEFSN GRFEQYMEST TLTCKTIRDP
160 170 180 190 200
KLSIYVGRRL CELHNFILLH PHEVLEMPAA WKNCLVWLPK AKAKILGRKH
210 220 230 240 250
SLAITSEFMK TLEEDFNAYY NWFVEWSRDK KDWFGLKMVF SHNDTQYGNL
260 270 280 290 300
LKIKAKKRSI PLSQKHRTLV PVDFEYAGPN LCAFDLANYF AEWMADYHHP
310 320 330 340 350
THNYLMDRSR YPDFNARKLV YHAYVEQSAV INDLLEIEDA SLLKTDISDE
360 370 380 390 400
LKNTFEKQIM NLEESVRAIS PAANIGWALW GILQCLEEDD EWEDLSVSSQ
410 420 430 440 450
VADRPEKQLV EGSTVPPIGT SSFDYIGYSS EKFDLFYEGC AALGLNGRNR

STFSYA
Length:456
Mass (Da):52,536
Last modified:October 1, 1996 - v1
Checksum:i08284FF1FC5FA089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93600.1.
PIRiS67441.
RefSeqiNP_593714.1. NM_001019145.2.

Genome annotation databases

EnsemblFungiiSPAC13G7.12c.1; SPAC13G7.12c.1:pep; SPAC13G7.12c.
GeneIDi2542839.
KEGGispo:SPAC13G7.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93600.1.
PIRiS67441.
RefSeqiNP_593714.1. NM_001019145.2.

3D structure databases

ProteinModelPortaliQ10276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279285. 30 interactions.
MINTiMINT-4698336.
STRINGi4896.SPAC13G7.12c-1.

Proteomic databases

MaxQBiQ10276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13G7.12c.1; SPAC13G7.12c.1:pep; SPAC13G7.12c.
GeneIDi2542839.
KEGGispo:SPAC13G7.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAC13G7.12c.
PomBaseiSPAC13G7.12c.

Phylogenomic databases

eggNOGiCOG0510.
InParanoidiQ10276.
KOiK00866.
OMAiFLIRIHC.
OrthoDBiEOG7WT48T.
PhylomeDBiQ10276.

Enzyme and pathway databases

UniPathwayiUPA00753; UER00737.
ReactomeiREACT_287143. Synthesis of PE.
REACT_297299. Synthesis of PC.

Miscellaneous databases

NextBioi20803880.
PROiQ10276.

Family and domain databases

InterProiIPR026712. Cho/Etha_kinase.
IPR007521. Choline_kin_N.
IPR011009. Kinase-like_dom.
[Graphical view]
PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
PfamiPF04428. Choline_kin_N. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiKICH_SCHPO
AccessioniPrimary (citable) accession number: Q10276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.