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Q10269 (AREH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable sterol O-acyltransferase 1
EC=2.3.1.26
Alternative name(s):
Sterol-ester synthase 1
Gene names
ORF Names:SPAC13G7.05
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.2.

Sequence similarities

Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Probable sterol O-acyltransferase 1
PRO_0000207652

Regions

Transmembrane98 – 11821Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane344 – 36421Helical; Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane462 – 48221Helical; Potential
Transmembrane517 – 53721Helical; Potential

Amino acid modifications

Glycosylation2501N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q10269 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 41DBA79402B67A28

FASTA53763,098
        10         20         30         40         50         60 
MTDTPRILIT PSPLSDISTT INKPNVHPSM SLLKALPECR LVVKSKGDKN NANVVEFPLD 

        70         80         90        100        110        120 
RHKQLLIAGK VYHDYKFKPR KSIFDRVTDP NYFAKSEFRG FYVLFWLSMA AWVLQLYARS 

       130        140        150        160        170        180 
YWQRDTLLGL PLARQVFRQF FVLFSSDFLM ICLSFFSYGL QVCIEKNMIR WANLGYTIQT 

       190        200        210        220        230        240 
LWQGFYMVLA VYWVKHRDFP IVQCVFFTLH CAVLIMKQFS YSHHMGYISE IRILHNEYEK 

       250        260        270        280        290        300 
LLKFVRECLN STEKDEKYTF ELTFPNKPAE TISTLQAEEI VALTAKYLSR QMRSEVGNVV 

       310        320        330        340        350        360 
YPDNINFFNY VDYLLVPSLV YSMEFPRVAH FRWHYMAFKA GSTFGLLALT LALVDWYFVP 

       370        380        390        400        410        420 
SAVAVKDLDF IGKLRIAPLL MNKIMFPAII LYLIMFYLIF DCILNAFAEI TKFADRGFYG 

       430        440        450        460        470        480 
AWWNTVTWDE FSREWNKPVH VFLMRHVYHS SISGFKLKKS HAVLLTFLIS ALVHEFVMLL 

       490        500        510        520        530 
ATGKFRCYIL TFQLLQIPLY DLQQMFAFKK RDILGNVFFW IGMFTGPSFL CILYIVF

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA93593.1.
PIRS67434.
RefSeqNP_593707.1. NM_001019138.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ10269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC13G7.05.1; SPAC13G7.05.1:pep; SPAC13G7.05.
GeneID2542851.
KEGGspo:SPAC13G7.05.
NMPDRfig|4896.1.peg.3677.

Organism-specific databases

GeneDB_SpombeSPAC13G7.05.

Phylogenomic databases

eggNOGfuNOG05746.
GeneTreeEFGT00050000004621.
OMAWDAILNC.
OrthoDBEOG40KC77.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001371-MONOMER.

Gene expression databases

ArrayExpressQ10269.

Family and domain databases

InterProIPR004299. MBOAT_fam.
IPR014371. Oat_ACAT_DAG_ARE.
[Graphical view]
KOK00637.
PANTHERPTHR10408. PTHR10408. 1 hit.
PfamPF03062. MBOAT. 1 hit.
[Graphical view]
PIRSFPIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAREH1_SCHPO
AccessionPrimary (citable) accession number: Q10269
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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