ID   HSP71_SCHPO             Reviewed;         644 AA.
AC   Q10265;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 162.
DE   RecName: Full=Probable heat shock protein ssa1;
GN   Name=ssa1; ORFNames=SPAC13G7.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAA93590.1; -; Genomic_DNA.
DR   PIR; S67431; S67431.
DR   RefSeq; NP_593704.1; NM_001019135.2.
DR   PDB; 3FP4; X-ray; 2.14 A; Q=633-644.
DR   PDBsum; 3FP4; -.
DR   AlphaFoldDB; Q10265; -.
DR   SMR; Q10265; -.
DR   BioGRID; 279320; 60.
DR   DIP; DIP-54582N; -.
DR   IntAct; Q10265; 4.
DR   MINT; Q10265; -.
DR   STRING; 284812.Q10265; -.
DR   iPTMnet; Q10265; -.
DR   MaxQB; Q10265; -.
DR   PaxDb; 4896-SPAC13G7-02c-1; -.
DR   EnsemblFungi; SPAC13G7.02c.1; SPAC13G7.02c.1:pep; SPAC13G7.02c.
DR   GeneID; 2542875; -.
DR   KEGG; spo:SPAC13G7.02c; -.
DR   PomBase; SPAC13G7.02c; ssa1.
DR   VEuPathDB; FungiDB:SPAC13G7.02c; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_3_0_1; -.
DR   InParanoid; Q10265; -.
DR   OMA; KANPIMM; -.
DR   PhylomeDB; Q10265; -.
DR   Reactome; R-SPO-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-SPO-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR   Reactome; R-SPO-3371568; Attenuation phase.
DR   Reactome; R-SPO-3371571; HSF1-dependent transactivation.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-8876725; Protein methylation.
DR   EvolutionaryTrace; Q10265; -.
DR   PRO; PR:Q10265; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0140602; C:nucleolar peripheral inclusion body; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0140453; C:protein aggregate center; IDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; ISO:PomBase.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375:SF395; HEAT SHOCK 70 KDA PROTEIN COGNATE 1-RELATED; 1.
DR   PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; ATP-binding; Cytoplasm; Nucleotide-binding;
KW   Reference proteome; Stress response.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..644
FT                   /note="Probable heat shock protein ssa1"
FT                   /id="PRO_0000078379"
FT   REGION          610..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   644 AA;  70143 MW;  1AD5E3B18FAC304E CRC64;
     MSKSIGIDLG TTYSCVGHFS NNRVEIIAND QGNRTTPSYV AFTDTERLIG DAAKNQVAMN
     PHNTIFDAKR LIGRRFNDPE VQSDMKHWPF KVIEKDGKPL IQVEFKGETK TFTPEEISSM
     VLLKMRESAE AFLGGKVTDA VVTVPAYFND SQRQATKDAG LIAGLNVLRI INEPTAAAIA
     YGLDRSNQHE TNVLIFDLGG GTFDVSLLTI EEGIFEVKAT AGDTHLGGED FDSRLVNHFA
     QEFKRKNKKD ITGNARAVRR LRTACERAKR TLSSSAQASI EIDSLYEGID FYTSITRARF
     EELCADLFRN TMEPVEKVLR DSKIDKSSVN EIVLVGGSTR IPRIQKLVSD FFNGKEPCKS
     INPDEAVAYG AAVQAAILVG DTSEKTQDLL LLDVAPLSLG IETAGGVMTP LIKRNTTIPT
     KKSEVFSTYA DNQPGVLIQV FEGERARTKD CNLLGKFELS GIPPAPRGVP QIEVTFDVDA
     NGILNVSALE KGTGKTQKIT ITNDKGRLSK EEIDRMVSEA EKYKAEDEAE TSRIQAKNHL
     ESYAYSLRNS LDDPNLKDKV DASDKEAIDK AVKETIEWLD HNTTAAKDEY EDKQKELEGV
     ANPIMAKIYQ AGGAPGGAPG GMPGGAPGGA PGGADNGPEV EEVD
//