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Q10251 (IF2P_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 5B

Short name=eIF-5B
Alternative name(s):
Translation initiation factor IF-2
Gene names
ORF Names:SPAC56F8.03
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1079 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 By similarity.

Sequence similarities

Belongs to the IF-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10791079Eukaryotic translation initiation factor 5B
PRO_0000137295

Regions

Nucleotide binding491 – 4988GTP By similarity

Amino acid modifications

Modified residue731Phosphoserine Ref.2
Modified residue771Phosphoserine Ref.2
Modified residue821Phosphoserine Ref.2
Modified residue1271Phosphoserine Ref.2
Modified residue3641Phosphothreonine Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q10251 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 73A01CE933C1F6AA

FASTA1,079119,931
        10         20         30         40         50         60 
MGKKGKKSGY ADWEDDLGED ISGQNEYLDN TSQDSPQNDE LAEKSENLAV SSEKTTSKKK 

        70         80         90        100        110        120 
KGKKNKGNKN QVSDDESQEL ESPQGPKELT AVTELDDDEF DYKPKKGKKG KKSKKVEEDD 

       130        140        150        160        170        180 
EPQEIESPQG PKELTAVTEL DDDEFDYKPK KGKKGKKAQN NNESEAAAPP EIPEVRVKTK 

       190        200        210        220        230        240 
KEKEREKKER EKLRKKQQQA KKKGSTGEDT LASSEVSSEV DISTPAENDS SAKGKQAAGS 

       250        260        270        280        290        300 
KRKGPNVTAL QKMLEEKRAR EEEEQRIREE EARIAEEEKR LAEVEEARKE EARLKKKEKE 

       310        320        330        340        350        360 
RKKKEEMKAQ GKYLSKKQKE QQALAQRRLQ QMLESGVRVA GLSNGEKKQK PVYTNKKKSN 

       370        380        390        400        410        420 
RSGTSSISSS GILESSPATS ISVDEPQKDS KDDSEKVEKE TEVERKEENE AEAEAVFDDW 

       430        440        450        460        470        480 
EAALEEPEVA ENNEVVTEKK ETDIKSDAVE HSIKDKEDSK TDKVDDIPQA APAESNVSES 

       490        500        510        520        530        540 
DLRSPICCIL GHVDTGKTKL LDNLRRSNVQ EGEAGGITQQ IGATYFPIES IKQKTKVVNK 

       550        560        570        580        590        600 
KGKLQYNIPG LLIIDTPGHE SFTNLRSRGT SLCNIAILVI DIMHGLEPQT IESIRLLRDQ 

       610        620        630        640        650        660 
KTPFVVALNK VDRLYGWHSI KDNAIQDSLS KQKKAIQREF RDRVESIILQ LNEQGLNAAL 

       670        680        690        700        710        720 
YFENKNLGRY VSLVPTSAQS GEGVPDLVAL LISLTQTRMS DRIKYITTLE CTVLEVKVIE 

       730        740        750        760        770        780 
GLGATIDVIL SNGVLHEGDR IVLCGMGGPI ITTVRALLTP QPLKEMRVKS AYVHHKEIKA 

       790        800        810        820        830        840 
AMGVKICAND LEKAVAGSRL LVVGPDDDEE DLAEEIMEDL ENLLGRIDTS GIGVSVQAST 

       850        860        870        880        890        900 
LGSLEALLEF LKQMKIPVAS VNIGPVYKKD VMRCATMLEK AKEYALMLCF DVKVDRDAED 

       910        920        930        940        950        960 
LAEQLGVKIF SANVIYHLFD AFTAHQKKIL EQKREESSDV AVFPCVLKTV AAFNKRDPII 

       970        980        990       1000       1010       1020 
LGVDVVEGVL RINTPIVAVK QLPNGEPQII ELGRVASLEM NHKPVDKVKK GQAGAGVAMK 

      1030       1040       1050       1060       1070 
LESSGSQILF GRQVTESDAL YSHITRQSID SLKDPAFRDE VSRDEWQLII QLKKLFGII 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-77; SER-82; SER-127 AND THR-364, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA93574.1.
PIRT38913.
RefSeqNP_593218.1. NM_001018614.2.

3D structure databases

ProteinModelPortalQ10251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279669. 3 interactions.
MINTMINT-4698132.
STRING4896.SPAC56F8.03-1.

Proteomic databases

MaxQBQ10251.
PaxDbQ10251.
PRIDEQ10251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC56F8.03.1; SPAC56F8.03.1:pep; SPAC56F8.03.
GeneID2543241.
KEGGspo:SPAC56F8.03.

Organism-specific databases

PomBaseSPAC56F8.03.

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000105770.
KOK03243.
OMAEAKRKDA.
OrthoDBEOG73BVNC.
PhylomeDBQ10251.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Other

NextBio20804263.
PROQ10251.

Entry information

Entry nameIF2P_SCHPO
AccessionPrimary (citable) accession number: Q10251
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Translation initiation factors

List of translation initiation factor entries