Q10242 (GNTK_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable gluconokinase
EC=2.7.1.12

Alternative name(s):
Gluconate kinase

Gene names

ORF Names:

SPAC4G9.12

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-gluconate = ADP + 6-phospho-D-gluconate.
Pathway	Carbohydrate acid metabolism; D-gluconate degradation.
Sequence similarities	Belongs to the gluconokinase GntK/GntV family.

Ontologies

Keywords
Biological process	Gluconate utilization
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-gluconate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway D-gluconate metabolic process Inferred from direct assay PubMed 7840612. Source: PomBase
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase nucleus Inferred from direct assay PubMed 16823372. Source: PomBase
Molecular_function	ATP binding Inferred by curator. Source: PomBase gluconokinase activity Inferred from direct assay PubMed 7840612. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Probable gluconokinase		PRO_0000087538
Regions
	Nucleotide binding	21 – 28	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q10242 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3CF12EAF231E72C7	FASTA	193	21,648
	10 20 30 40 50 60 MTVTPINPTN QPYKYVFVVI GPAGSGKTTM AKAVSEKLGF EYIEGDDLHP KANIEKMSQG 70 80 90 100 110 120 HPLNDNDRWG WLHNCGGACA MELDKESIKG VVLTCSALKR SYRDILRSSL EHRPAILRFI 130 140 150 160 170 180 YLAASRETLI KRTTSRKNHY MKADMVESQL AILEAPTADE KDVITISVEN GKEQSEEECL 190 DIVHKMVNEN KQP

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA93562.1.
PIR	T38871.
RefSeq	NP_593694.1. NM_001019126.2.
3D structure databases
ProteinModelPortal	Q10242.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPAC4G9.12-1.
Proteomic databases
PaxDb	Q10242.
PRIDE	Q10242.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC4G9.12.1; SPAC4G9.12.1:pep; SPAC4G9.12.
GeneID	2543385.
KEGG	spo:SPAC4G9.12.
Organism-specific databases
PomBase	SPAC4G9.12.
Phylogenomic databases
eggNOG	COG3265.
HOGENOM	HOG000032567.
KO	K00851.
OMA	LRDGNPN.
OrthoDB	EOG47WRXX.
Enzyme and pathway databases
UniPathway	UPA00792.
Family and domain databases
InterPro	IPR006001. Therm_gnt_kin. [Graphical view]
TIGRFAMs	TIGR01313. therm_gnt_kin. 1 hit.
ProtoNet	Search...
Other
NextBio	20804400.

Entry information

Entry name

GNTK_SCHPO

Accession

Primary (citable) accession number: Q10242

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program