Reviewed, UniProtKB/Swiss-Prot Q10242 (GNTK_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable gluconokinase
    EC=2.7.1.12
Alternative name(s):
    Gluconate kinase

Gene names

ORF Names:

SPAC4G9.12

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-gluconate = ADP + 6-phospho-D-gluconate.
Pathway	Carbohydrate acid metabolism; D-gluconic acid degradation.
Sequence similarities	Belongs to the gluconokinase gntK/gntV family.

Ontologies

Keywords
Biological process	Gluconate utilization
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from direct assay. Source: GeneDB_SPombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	ATP binding Inferred by curator. Source: GeneDB_SPombe gluconokinase activity Inferred from direct assay. Source: GeneDB_SPombe shikimate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Probable gluconokinase		PRO_0000087538
Regions
	Nucleotide binding	21 – 28	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q10242-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3CF12EAF231E72C7	FASTA	193	21,648
	10 20 30 40 50 60 MTVTPINPTN QPYKYVFVVI GPAGSGKTTM AKAVSEKLGF EYIEGDDLHP KANIEKMSQG 70 80 90 100 110 120 HPLNDNDRWG WLHNCGGACA MELDKESIKG VVLTCSALKR SYRDILRSSL EHRPAILRFI 130 140 150 160 170 180 YLAASRETLI KRTTSRKNHY MKADMVESQL AILEAPTADE KDVITISVEN GKEQSEEECL 190 DIVHKMVNEN KQP

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAA93562.1.
PIR	T38871.
RefSeq	NP_593694.1.
3D structure databases
HSSP	HSSP built from PDB template 1KO1 based on UniProtKB P46859.
ModBase	Search...
Genome annotation databases
GeneID	2543385.
KEGG	spo:SPAC4G9.12.
NMPDR	fig|4896.1.peg.3664.
Organism-specific databases
GeneDB_Spombe	SPAC4G9.12.
Phylogenomic databases
OMA	Q10242. GLRSAHR.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001360-MON.
BRENDA	2.7.1.12. 653.
Gene expression databases
ArrayExpress	Q10242.
Family and domain databases
InterPro	IPR000623. Shik_kinase. IPR006001. Therm_gnt_kin. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
TIGRFAMs	TIGR01313. therm_gnt_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GNTK_SCHPO

Accession

Primary (citable) accession number: Q10242

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)