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Protein

Ribonuclease H2 subunit A

Gene

rnh201

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mn2+By similarity, Mg2+By similarityNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Divalent metal cationBy similarity1
Metal bindingi70Divalent metal cationBy similarity1
Metal bindingi180Divalent metal cationBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: InterPro
  • RNA-DNA hybrid ribonuclease activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit A (EC:3.1.26.4)
Short name:
RNase H2 subunit A
Alternative name(s):
Ribonuclease HI large subunit
Short name:
RNase HI large subunit
Ribonuclease HI subunit A
Gene namesi
Name:rnh201
ORF Names:SPAC4G9.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4G9.02
PomBaseiSPAC4G9.02 rnh201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117171 – 326Ribonuclease H2 subunit AAdd BLAST326

Proteomic databases

MaxQBiQ10236
PaxDbiQ10236
PRIDEiQ10236

Interactioni

Protein-protein interaction databases

BioGridi278042, 25 interactors
STRINGi4896.SPAC4G9.02.1

Structurei

3D structure databases

ProteinModelPortaliQ10236
SMRiQ10236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family. Eukaryotic subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000100290
InParanoidiQ10236
KOiK10743
OMAiGAMVYAC
OrthoDBiEOG092C57KP
PhylomeDBiQ10236

Family and domain databases

Gene3Di1.10.10.460, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR004649 RNase_H2_suA
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR023160 RNase_HII_hlx-loop-hlx_cap_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00729 TIGR00729, 1 hit

Sequencei

Sequence statusi: Complete.

Q10236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDDHDAWEP EELVSDNNSS ENELQEDQNS SITFLPPSVN KSNPAKSNYY
60 70 80 90 100
HSTVTDDISK SQPYRLGVDE AGRGPVLGPM VYAVAYCPVD FDLTNYGFAD
110 120 130 140 150
SKTLASLKRE ELLKLICNKS NELGKNVGWS TMSISARELA AGMLRYRNKY
160 170 180 190 200
NLNLQAHDTT IDLIKKVYES GINVTEIYVD TVGPPISYQE KLQAHFPQAK
210 220 230 240 250
VTVTKKADSL FPIVSLASIC AKVTRDIQLE CARESIRTEN WGSGYSSDAR
260 270 280 290 300
TTEWLKVNVD KIFGWKGDIV RYSWKTAKDL LELPSKSQSS IEIDWHEDDD
310 320
TPTLNFTQKK KPNPASRSWF GSEFYF
Length:326
Mass (Da):36,808
Last modified:October 1, 1996 - v1
Checksum:i04E82E145CF0CCD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93552.1
PIRiT38861
RefSeqiNP_593684.1, NM_001019116.2

Genome annotation databases

EnsemblFungiiSPAC4G9.02.1; SPAC4G9.02.1:pep; SPAC4G9.02
GeneIDi2541542
KEGGispo:SPAC4G9.02

Similar proteinsi

Entry informationi

Entry nameiRNH2A_SCHPO
AccessioniPrimary (citable) accession number: Q10236
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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