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Reviewed, UniProtKB/Swiss-Prot Q10235 (ALP11_SCHPO)

Last modified November 24, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cell polarity protein alp11
Alternative name(s):
    Altered polarity protein 11
Gene names
Name: alp11
ORF Names: SPAC13D6.05, SPAC4G9.01
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin. Ref.1 Ref.2

Subunit structure

Binds to monomeric alpha-tubulin. Interacts with alp21. Ref.2

Subcellular location

Cytoplasm › cytoskeleton.

Sequence similarities

Belongs to the TBCB family.

Contains 1 CAP-Gly domain.

Contains 1 ubiquitin-like domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Molecular functionChaperone
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpost-chaperonin tubulin folding pathway

Non-traceable author statement. Source: GeneDB_SPombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_SPombe

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functionalpha-tubulin binding Ref.1

Inferred from physical interaction. Source: GeneDB_SPombe

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Cell polarity protein alp11
PRO_0000083512

Regions

Domain4 – 8885Ubiquitin-like
Domain174 – 21643CAP-Gly

Amino acid modifications

Modified residue2131Phosphoserine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Q10235-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7E4D8B5C3D9D5981

FASTA23426,672
        10         20         30         40         50         60 
MNEITLFIKS SSANAERRIN PQWTVSQLKT KLVPIVGTPE QYQKLTYEPA SSTVPGHVFT 

        70         80         90        100        110        120 
SEEENLDLGE FKLQPLGTIV VEDTRPPHLR LDFDDLSQVD KYVMPREQYE NRTDSVYAWK 

       130        140        150        160        170        180 
KRNQLGRFNP DFEASKASRQ ESLKRELVDL QKNLNSRCCA AGERYGTIRY IGLVPEINND 

       190        200        210        220        230 
NLWVGVEFDE PVGKNDGTVS GKRYFNAKNK HGSFLRSSEV EVGDFPPEDI LEGL

« Hide

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References

« Hide 'large scale' references
[1]"Characterisation of fission yeast alp11 mutants defines three functional domains within tubulin-folding cofactor B."
Radcliffe P.A., Toda T.
Mol. Gen. Genet. 263:752-760(2000) [PubMed: 10905343] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast."
Radcliffe P.A., Hirata D., Vardy L., Toda T.
Mol. Biol. Cell 10:2987-3001(1999) [PubMed: 10473641] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH ALPHA-TUBULIN AND ALP21, SUBCELLULAR LOCATION.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, MASS SPECTROMETRY.

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Cross-references

Sequence databases

AB008750 Genomic DNA. Translation: BAA23375.1.
CU329670 Genomic DNA. Translation: CAB59431.1.
PIRT43283.
RefSeqNP_593683.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ10235.

Genome annotation databases

GeneID2542814.
GenomeReviewsGene locus alp11 in contig CU329670_GR.
KEGGspo:SPAC13D6.05.

Organism-specific databases

GeneDB_SpombeSPAC13D6.05.

Phylogenomic databases

OMARRISPQW
OrthoDBEOG95B2XZ

Gene expression databases

ArrayExpressQ10235.

Family and domain databases

InterProIPR000938. Cytoskel-assoc-prot_CAP-Gly.
IPR000626. Ubiquitin.
IPR019955. Ubiquitin_supergroup.
[Graphical view]
PfamPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
PROSITEPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALP11_SCHPO
AccessionPrimary (citable) accession number: Q10235
Secondary accession number(s): Q9UTM6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents