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Protein

Cell polarity protein alp11

Gene

alp11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin.2 Publications

GO - Biological processi

  • cytoplasmic microtubule organization Source: PomBase
  • microtubule cytoskeleton organization Source: PomBase
  • tubulin complex assembly Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Cell polarity protein alp11
Alternative name(s):
Altered polarity protein 11
Gene namesi
Name:alp11
ORF Names:SPAC13D6.05, SPAC4G9.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.05.
PomBaseiSPAC13D6.05. alp11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • microtubule Source: UniProtKB-KW
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835121 – 234Cell polarity protein alp11Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei213Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10235.
PRIDEiQ10235.

PTM databases

iPTMnetiQ10235.

Interactioni

Subunit structurei

Binds to monomeric alpha-tubulin. Interacts with alp21.1 Publication

Protein-protein interaction databases

BioGridi279261. 3 interactors.
MINTiMINT-4698014.

Structurei

3D structure databases

ProteinModelPortaliQ10235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 88Ubiquitin-likePROSITE-ProRule annotationAdd BLAST85
Domaini174 – 216CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the TBCB family.Curated
Contains 1 CAP-Gly domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000209180.
InParanoidiQ10235.
KOiK17262.
OMAiHGSFVKP.
OrthoDBiEOG092C54ZV.
PhylomeDBiQ10235.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEITLFIKS SSANAERRIN PQWTVSQLKT KLVPIVGTPE QYQKLTYEPA
60 70 80 90 100
SSTVPGHVFT SEEENLDLGE FKLQPLGTIV VEDTRPPHLR LDFDDLSQVD
110 120 130 140 150
KYVMPREQYE NRTDSVYAWK KRNQLGRFNP DFEASKASRQ ESLKRELVDL
160 170 180 190 200
QKNLNSRCCA AGERYGTIRY IGLVPEINND NLWVGVEFDE PVGKNDGTVS
210 220 230
GKRYFNAKNK HGSFLRSSEV EVGDFPPEDI LEGL
Length:234
Mass (Da):26,672
Last modified:October 1, 1996 - v1
Checksum:i7E4D8B5C3D9D5981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008750 Genomic DNA. Translation: BAA23375.1.
CU329670 Genomic DNA. Translation: CAB59431.1.
PIRiT43283.
RefSeqiNP_593683.2. NM_001019115.2.

Genome annotation databases

EnsemblFungiiSPAC13D6.05.1; SPAC13D6.05.1:pep; SPAC13D6.05.
GeneIDi2542814.
KEGGispo:SPAC13D6.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008750 Genomic DNA. Translation: BAA23375.1.
CU329670 Genomic DNA. Translation: CAB59431.1.
PIRiT43283.
RefSeqiNP_593683.2. NM_001019115.2.

3D structure databases

ProteinModelPortaliQ10235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279261. 3 interactors.
MINTiMINT-4698014.

PTM databases

iPTMnetiQ10235.

Proteomic databases

MaxQBiQ10235.
PRIDEiQ10235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13D6.05.1; SPAC13D6.05.1:pep; SPAC13D6.05.
GeneIDi2542814.
KEGGispo:SPAC13D6.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.05.
PomBaseiSPAC13D6.05. alp11.

Phylogenomic databases

HOGENOMiHOG000209180.
InParanoidiQ10235.
KOiK17262.
OMAiHGSFVKP.
OrthoDBiEOG092C54ZV.
PhylomeDBiQ10235.

Miscellaneous databases

PROiQ10235.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALP11_SCHPO
AccessioniPrimary (citable) accession number: Q10235
Secondary accession number(s): Q9UTM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.