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Protein

DNA-directed RNA polymerase III subunit RPC2

Gene

rpc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1111ZincBy similarity1
Metal bindingi1114ZincBy similarity1
Metal bindingi1123ZincBy similarity1
Metal bindingi1126ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1111 – 1126C4-typeBy similarityAdd BLAST16

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC2 (EC:2.7.7.6)
Short name:
RNA polymerase III subunit 2
Short name:
RNA polymerase III subunit C2
Alternative name(s):
C128
DNA-directed RNA polymerase III 130 kDa polypeptide
RPC130
Gene namesi
Name:rpc2
ORF Names:SPAC4G9.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4G9.08c
PomBaseiSPAC4G9.08c rpc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000480951 – 1165DNA-directed RNA polymerase III subunit RPC2Add BLAST1165

Proteomic databases

MaxQBiQ10233
PaxDbiQ10233
PRIDEiQ10233

PTM databases

iPTMnetiQ10233

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.By similarity

Protein-protein interaction databases

BioGridi279815, 4 interactors
DIPiDIP-29536N
IntActiQ10233, 3 interactors
STRINGi4896.SPAC4G9.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ10233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1111 – 1126C4-typeBy similarityAdd BLAST16

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000222962
InParanoidiQ10233
KOiK03021
OMAiMLCTSDT
OrthoDBiEOG092C06IY
PhylomeDBiQ10233

Family and domain databases

CDDicd00653 RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 3 hits
2.40.50.150, 2 hits
3.90.1110.10, 1 hit
InterProiView protein in InterPro
IPR015712 DNA-dir_RNA_pol_su2
IPR007120 DNA-dir_RNAP_su2_dom
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR007121 RNA_pol_bsu_CS
IPR007644 RNA_pol_bsu_protrusion
IPR007642 RNA_pol_Rpb2_2
IPR037034 RNA_pol_Rpb2_2_sf
IPR007645 RNA_pol_Rpb2_3
IPR007646 RNA_pol_Rpb2_4
IPR007647 RNA_pol_Rpb2_5
IPR007641 RNA_pol_Rpb2_7
IPR014724 RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856 PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563 RNA_pol_Rpb2_1, 1 hit
PF04561 RNA_pol_Rpb2_2, 1 hit
PF04565 RNA_pol_Rpb2_3, 1 hit
PF04566 RNA_pol_Rpb2_4, 1 hit
PF04567 RNA_pol_Rpb2_5, 1 hit
PF00562 RNA_pol_Rpb2_6, 1 hit
PF04560 RNA_pol_Rpb2_7, 1 hit
PROSITEiView protein in PROSITE
PS01166 RNA_POL_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q10233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVNTAGDPQ KSQPKINKGG IGKDESFGAL FKPVYKGKKL ADPVPTIEDK
60 70 80 90 100
WQLLPAFLKV KGLVKQHLDS YNYFVDVDLK KIVQANEKVT SDVEPWFYLK
110 120 130 140 150
YLDIRVGAPV RTDADAIQAS ISPHECRLRD LTYGANIYVD IEYTRGKQVV
160 170 180 190 200
RRRNVPIGRM PVMLRSNKCV LSGKNEMEMA ALNECPLDPG GYFIVKGTEK
210 220 230 240 250
VILVQEQLSK NRIIVEAEPK KGLWQASVTS STHERKSKTY VITKNGKLYL
260 270 280 290 300
KHNSVADDIP IVVVLKAMGL QSDQEIFELV AGAEASYQDL FAPSIEECAK
310 320 330 340 350
LNIYTAQQAL EYIGARVKVN RRAGANRLPP HEEALEVLAA VVLAHINVFN
360 370 380 390 400
LEFRPKAVYI GIMARRVLMA MVDPLQVDDR DYVGNKRLEL AGQLLALLFE
410 420 430 440 450
DLFKKFNSDL KLNIDKVLKK PHRTQEFDAY NQLTVHSDHI TQGMVRALST
460 470 480 490 500
GNWSLKRFKM ERAGVTHVLS RLSYISALGM MTRITSQFEK TRKVSGPRSL
510 520 530 540 550
QASQFGMLCT SDTPEGEACG LVKNLALMTH ITTDEEEEPI IKLAYAFGIE
560 570 580 590 600
DIHVISGREL HSHGTYLVYL NGAILGISRY PSLFVASFRK LRRSGKISPF
610 620 630 640 650
IGIFINTHQR AVFISTDGGR ICRPLIIVQN GLPKVESKHI RLLKEGKWGF
660 670 680 690 700
EDFLKQGLVE YVDVNEENDS LISVYERDIT PDTTHLEIEP FTILGAVAGL
710 720 730 740 750
IPYPHHNQSP RNTYQCAMGK QAIGAIAYNQ LQRIDTLLYL MVYPQQPMVK
760 770 780 790 800
TKTIELIGYD KLPAGQNATV AIMSYSGYDI EDALVLNKSS IDRGFGRCQV
810 820 830 840 850
FHKHSVIVRK YPNGTHDRIG DPQRDPETGE VVWKHGVVED DGLAGVGCRV
860 870 880 890 900
QPGQIYVNKQ TPTNALDNSI TLGHTQTVES GYKATPMTYK APEPGYIDKV
910 920 930 940 950
MLTTTDSDQT LIKVLMRQTR RPELGDKFSS RHGQKGVCGV IVQQEDMPFN
960 970 980 990 1000
DQGICPDIIM NPHGFPSRMT VGKMIELLSG KVGVLRGTLE YGTCFGGTKV
1010 1020 1030 1040 1050
EDASRILVEH GYNYSGKDML TSGITGETLE AYIFMGPIYY QKLKHMVMDK
1060 1070 1080 1090 1100
MHARARGPRA VLTRQPTEGR SRDGGLRLGE MERDCLIAYG ASQLLLERLM
1110 1120 1130 1140 1150
ISSDACDVDV CGQCGLLGYK GWCNSCQSTR EVVKMTIPYA AKLLFQELLS
1160
MNIVPRLALE DEFKY
Length:1,165
Mass (Da):130,238
Last modified:October 1, 1996 - v1
Checksum:i6690055F257EC0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ156226 mRNA Translation: ABA54854.1
CU329670 Genomic DNA Translation: CAA93558.1
PIRiT38867
RefSeqiNP_593690.1, NM_001019122.2

Genome annotation databases

EnsemblFungiiSPAC4G9.08c.1; SPAC4G9.08c.1:pep; SPAC4G9.08c
GeneIDi2543393
KEGGispo:SPAC4G9.08c

Similar proteinsi

Entry informationi

Entry nameiRPC2_SCHPO
AccessioniPrimary (citable) accession number: Q10233
Secondary accession number(s): Q0QYE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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