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Q10231

- ERG7_SCHPO

UniProt

Q10231 - ERG7_SCHPO

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Protein

Lanosterol synthase

Gene
erg7, SPAC13G7.01c, SPAC4G9.21c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei229 – 2291Proton acceptor By similarity
Active sitei451 – 4511Proton donor By similarity

GO - Molecular functioni

  1. lanosterol synthase activity Source: PomBase

GO - Biological processi

  1. ergosterol biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00767; UER00753.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol synthase (EC:5.4.99.7)
Alternative name(s):
2,3-epoxysqualene--lanosterol cyclase
Oxidosqualene--lanosterol cyclase
Short name:
OSC
Gene namesi
Name:erg7
ORF Names:SPAC13G7.01c, SPAC4G9.21c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13G7.01c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. endoplasmic reticulum Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Lanosterol synthasePRO_0000072656Add
BLAST

Proteomic databases

MaxQBiQ10231.

Interactioni

Protein-protein interaction databases

MINTiMINT-4697960.
STRINGi4896.SPAC13G7.01c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10231.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati121 – 16242PFTB 1Add
BLAST
Repeati555 – 59541PFTB 2Add
BLAST
Repeati604 – 64542PFTB 3Add
BLAST
Repeati662 – 70342PFTB 4Add
BLAST

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1657.
HOGENOMiHOG000234317.
KOiK01852.
OMAiTNGLQVW.
OrthoDBiEOG70610B.
PhylomeDBiQ10231.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 3 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10231-1 [UniParc]FASTAAdd to Basket

« Hide

MEACRVRPEL SKTVEQIDKS LWRLNIDSAG GETWEYVTKE EAEKRPLTIA    50
EKYFLGFDLD LPKRPPAKTP LESAEYGYEF FRRLQLPDGH WASPYEGPMF 100
LICGAVFAFY ISQTPFPKGW APEIIQYLIN HTNDDGGWGI HTEGVSTVFG 150
TSMNYVVLRI LGMDAGHPVA TRARNRLHEL GGAIGCPHWG KFWLATLNCY 200
DWDGVNPIPP ELWLLPDWIP FHPGKWWCHV RLVYLPMGYM YGERLKCPKD 250
SLIMQLRKEL YVENYDSINF ADHRNTISDV DLYFPHTQIL DRLNWILEKY 300
FTYLRPSWLK KLGTRRAYEL IKIEDQNTDY SCIGPVNAAM NTVCVYFHEG 350
PSSKAFQKHI QRLHDFMWVQ PEGMLMRGTN GLQVWETSFT LQALVESGLY 400
EKEAFKPDIA KALEFLDRQQ IRTQYEGSGY RYNSLGAWPF SNITQGYTVS 450
DTTSEALRAV LLVQSLPDFE KLVDIPRLRL SVDVILGMQN ENLGFASYEP 500
ARTGEWMELL NPAEVFGNIM VEYSYPECTT SVILALRAFT KYDPGYRRDE 550
IENTIENALE YVVKMQRPDG SWYGSWAICF TYAAMFATGS LASAGRYYEN 600
CPVQKKACEF LLSKQRPDGG WSESYMACVT GVYTETESSL VTQTGWALDA 650
LINAKYPDRK PIEKGIKFLM ASQKSDGSWQ QKSMEGIFNK NVAIAYPNYK 700
LYFSIYTLGK FAKQYGNYLT I 721
Length:721
Mass (Da):82,819
Last modified:October 1, 1996 - v1
Checksum:i445B67F4BF7BFBA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41368 mRNA. Translation: AAA92502.1.
CU329670 Genomic DNA. Translation: CAA93571.1.
PIRiJC4643.
RefSeqiNP_593702.2. NM_001019134.2.

Genome annotation databases

EnsemblFungiiSPAC13G7.01c.1; SPAC13G7.01c.1:pep; SPAC13G7.01c.
GeneIDi2542882.
KEGGispo:SPAC13G7.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41368 mRNA. Translation: AAA92502.1 .
CU329670 Genomic DNA. Translation: CAA93571.1 .
PIRi JC4643.
RefSeqi NP_593702.2. NM_001019134.2.

3D structure databases

ProteinModelPortali Q10231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4697960.
STRINGi 4896.SPAC13G7.01c-1.

Proteomic databases

MaxQBi Q10231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13G7.01c.1 ; SPAC13G7.01c.1:pep ; SPAC13G7.01c .
GeneIDi 2542882.
KEGGi spo:SPAC13G7.01c.

Organism-specific databases

PomBasei SPAC13G7.01c.

Phylogenomic databases

eggNOGi COG1657.
HOGENOMi HOG000234317.
KOi K01852.
OMAi TNGLQVW.
OrthoDBi EOG70610B.
PhylomeDBi Q10231.

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00753 .

Miscellaneous databases

NextBioi 20803922.
PROi Q10231.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 3 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues."
    Corey E.J., Matsuda S.P.T., Baker C.H., Ting A.Y., Cheng H.
    Biochem. Biophys. Res. Commun. 219:327-331(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiERG7_SCHPO
AccessioniPrimary (citable) accession number: Q10231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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