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Q10231

- ERG7_SCHPO

UniProt

Q10231 - ERG7_SCHPO

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Protein

Lanosterol synthase

Gene

erg7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei229 – 2291Proton acceptorBy similarity
Active sitei451 – 4511Proton donorBy similarity

GO - Molecular functioni

  1. lanosterol synthase activity Source: PomBase

GO - Biological processi

  1. ergosterol biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00767; UER00753.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol synthase (EC:5.4.99.7)
Alternative name(s):
2,3-epoxysqualene--lanosterol cyclase
Oxidosqualene--lanosterol cyclase
Short name:
OSC
Gene namesi
Name:erg7
ORF Names:SPAC13G7.01c, SPAC4G9.21c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13G7.01c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Lanosterol synthasePRO_0000072656Add
BLAST

Proteomic databases

MaxQBiQ10231.

Interactioni

Protein-protein interaction databases

MINTiMINT-4697960.
STRINGi4896.SPAC13G7.01c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati121 – 16242PFTB 1Add
BLAST
Repeati555 – 59541PFTB 2Add
BLAST
Repeati604 – 64542PFTB 3Add
BLAST
Repeati662 – 70342PFTB 4Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1657.
HOGENOMiHOG000234317.
InParanoidiQ10231.
KOiK01852.
OMAiTNGLQVW.
OrthoDBiEOG70610B.
PhylomeDBiQ10231.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 3 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEACRVRPEL SKTVEQIDKS LWRLNIDSAG GETWEYVTKE EAEKRPLTIA
60 70 80 90 100
EKYFLGFDLD LPKRPPAKTP LESAEYGYEF FRRLQLPDGH WASPYEGPMF
110 120 130 140 150
LICGAVFAFY ISQTPFPKGW APEIIQYLIN HTNDDGGWGI HTEGVSTVFG
160 170 180 190 200
TSMNYVVLRI LGMDAGHPVA TRARNRLHEL GGAIGCPHWG KFWLATLNCY
210 220 230 240 250
DWDGVNPIPP ELWLLPDWIP FHPGKWWCHV RLVYLPMGYM YGERLKCPKD
260 270 280 290 300
SLIMQLRKEL YVENYDSINF ADHRNTISDV DLYFPHTQIL DRLNWILEKY
310 320 330 340 350
FTYLRPSWLK KLGTRRAYEL IKIEDQNTDY SCIGPVNAAM NTVCVYFHEG
360 370 380 390 400
PSSKAFQKHI QRLHDFMWVQ PEGMLMRGTN GLQVWETSFT LQALVESGLY
410 420 430 440 450
EKEAFKPDIA KALEFLDRQQ IRTQYEGSGY RYNSLGAWPF SNITQGYTVS
460 470 480 490 500
DTTSEALRAV LLVQSLPDFE KLVDIPRLRL SVDVILGMQN ENLGFASYEP
510 520 530 540 550
ARTGEWMELL NPAEVFGNIM VEYSYPECTT SVILALRAFT KYDPGYRRDE
560 570 580 590 600
IENTIENALE YVVKMQRPDG SWYGSWAICF TYAAMFATGS LASAGRYYEN
610 620 630 640 650
CPVQKKACEF LLSKQRPDGG WSESYMACVT GVYTETESSL VTQTGWALDA
660 670 680 690 700
LINAKYPDRK PIEKGIKFLM ASQKSDGSWQ QKSMEGIFNK NVAIAYPNYK
710 720
LYFSIYTLGK FAKQYGNYLT I
Length:721
Mass (Da):82,819
Last modified:October 1, 1996 - v1
Checksum:i445B67F4BF7BFBA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41368 mRNA. Translation: AAA92502.1.
CU329670 Genomic DNA. Translation: CAA93571.1.
PIRiJC4643.
RefSeqiNP_593702.2. NM_001019134.2.

Genome annotation databases

EnsemblFungiiSPAC13G7.01c.1; SPAC13G7.01c.1:pep; SPAC13G7.01c.
GeneIDi2542882.
KEGGispo:SPAC13G7.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41368 mRNA. Translation: AAA92502.1 .
CU329670 Genomic DNA. Translation: CAA93571.1 .
PIRi JC4643.
RefSeqi NP_593702.2. NM_001019134.2.

3D structure databases

ProteinModelPortali Q10231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4697960.
STRINGi 4896.SPAC13G7.01c-1.

Proteomic databases

MaxQBi Q10231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13G7.01c.1 ; SPAC13G7.01c.1:pep ; SPAC13G7.01c .
GeneIDi 2542882.
KEGGi spo:SPAC13G7.01c.

Organism-specific databases

PomBasei SPAC13G7.01c.

Phylogenomic databases

eggNOGi COG1657.
HOGENOMi HOG000234317.
InParanoidi Q10231.
KOi K01852.
OMAi TNGLQVW.
OrthoDBi EOG70610B.
PhylomeDBi Q10231.

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00753 .

Miscellaneous databases

NextBioi 20803922.
PROi Q10231.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 3 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues."
    Corey E.J., Matsuda S.P.T., Baker C.H., Ting A.Y., Cheng H.
    Biochem. Biophys. Res. Commun. 219:327-331(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiERG7_SCHPO
AccessioniPrimary (citable) accession number: Q10231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3