Reviewed,
UniProtKB/Swiss-Prot Q10231 (ERG7_SCHPO)
Last modified
May 5, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Lanosterol synthase EC=5.4.99.7 Alternative name(s): Oxidosqualene--lanosterol cyclase Short name=OSC 2,3-epoxysqualene--lanosterol cyclase | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 721 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. |
| Catalytic activity | (S)-2,3-epoxysqualene = lanosterol. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl-PP: step 3/3. |
| Sequence similarities | Belongs to the terpene cyclase/mutase family. Contains 4 PFTB repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis |
| Domain | Repeat |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | steroid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | lanosterol synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 721 | 721 | Lanosterol synthase | PRO_0000072656 | |||||
Regions | |||||||||
| Repeat | 121 – 162 | 42 | PFTB 1 | ||||||
| Repeat | 555 – 595 | 41 | PFTB 2 | ||||||
| Repeat | 604 – 645 | 42 | PFTB 3 | ||||||
| Repeat | 662 – 703 | 42 | PFTB 4 | ||||||
Sites | |||||||||
| Active site | 229 | 1 | Proton acceptor By similarity | ||||||
| Active site | 451 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues." Corey E.J., Matsuda S.P.T., Baker C.H., Ting A.Y., Cheng H. Biochem. Biophys. Res. Commun. 219:327-331(1996) [PubMed: 8604986] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| U41368 mRNA. Translation: AAA92502.1. CU329670 Genomic DNA. Translation: CAA93571.1. | |
| PIR | JC4643. |
| RefSeq | NP_593702.2. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2542882. |
| KEGG | spo:SPAC13G7.01c. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC13G7.01c. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-002010-MON. |
| BRENDA | 5.4.99.7. 653. |
Gene expression databases | |
| ArrayExpress | Q10231. |
Family and domain databases | |
| InterPro | IPR001330. Prenyltrans. IPR018333. Squalene_cyclase. IPR002365. Terpene_synthase_CS. [Graphical view] |
| Pfam | PF00432. Prenyltrans. 3 hits. [Graphical view] |
| TIGRFAMs | TIGR01787. squalene_cyclas. 1 hit. |
| PROSITE | PS01074. TERPENE_SYNTHASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERG7_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q10231 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


