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Q10231

- ERG7_SCHPO

UniProt

Q10231 - ERG7_SCHPO

Protein

Lanosterol synthase

Gene

erg7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei229 – 2291Proton acceptorBy similarity
    Active sitei451 – 4511Proton donorBy similarity

    GO - Molecular functioni

    1. lanosterol synthase activity Source: PomBase

    GO - Biological processi

    1. ergosterol biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00767; UER00753.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lanosterol synthase (EC:5.4.99.7)
    Alternative name(s):
    2,3-epoxysqualene--lanosterol cyclase
    Oxidosqualene--lanosterol cyclase
    Short name:
    OSC
    Gene namesi
    Name:erg7
    ORF Names:SPAC13G7.01c, SPAC4G9.21c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC13G7.01c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. endoplasmic reticulum Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Lanosterol synthasePRO_0000072656Add
    BLAST

    Proteomic databases

    MaxQBiQ10231.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4697960.
    STRINGi4896.SPAC13G7.01c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati121 – 16242PFTB 1Add
    BLAST
    Repeati555 – 59541PFTB 2Add
    BLAST
    Repeati604 – 64542PFTB 3Add
    BLAST
    Repeati662 – 70342PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1657.
    HOGENOMiHOG000234317.
    KOiK01852.
    OMAiTNGLQVW.
    OrthoDBiEOG70610B.
    PhylomeDBiQ10231.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 3 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10231-1 [UniParc]FASTAAdd to Basket

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    MEACRVRPEL SKTVEQIDKS LWRLNIDSAG GETWEYVTKE EAEKRPLTIA    50
    EKYFLGFDLD LPKRPPAKTP LESAEYGYEF FRRLQLPDGH WASPYEGPMF 100
    LICGAVFAFY ISQTPFPKGW APEIIQYLIN HTNDDGGWGI HTEGVSTVFG 150
    TSMNYVVLRI LGMDAGHPVA TRARNRLHEL GGAIGCPHWG KFWLATLNCY 200
    DWDGVNPIPP ELWLLPDWIP FHPGKWWCHV RLVYLPMGYM YGERLKCPKD 250
    SLIMQLRKEL YVENYDSINF ADHRNTISDV DLYFPHTQIL DRLNWILEKY 300
    FTYLRPSWLK KLGTRRAYEL IKIEDQNTDY SCIGPVNAAM NTVCVYFHEG 350
    PSSKAFQKHI QRLHDFMWVQ PEGMLMRGTN GLQVWETSFT LQALVESGLY 400
    EKEAFKPDIA KALEFLDRQQ IRTQYEGSGY RYNSLGAWPF SNITQGYTVS 450
    DTTSEALRAV LLVQSLPDFE KLVDIPRLRL SVDVILGMQN ENLGFASYEP 500
    ARTGEWMELL NPAEVFGNIM VEYSYPECTT SVILALRAFT KYDPGYRRDE 550
    IENTIENALE YVVKMQRPDG SWYGSWAICF TYAAMFATGS LASAGRYYEN 600
    CPVQKKACEF LLSKQRPDGG WSESYMACVT GVYTETESSL VTQTGWALDA 650
    LINAKYPDRK PIEKGIKFLM ASQKSDGSWQ QKSMEGIFNK NVAIAYPNYK 700
    LYFSIYTLGK FAKQYGNYLT I 721
    Length:721
    Mass (Da):82,819
    Last modified:October 1, 1996 - v1
    Checksum:i445B67F4BF7BFBA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41368 mRNA. Translation: AAA92502.1.
    CU329670 Genomic DNA. Translation: CAA93571.1.
    PIRiJC4643.
    RefSeqiNP_593702.2. NM_001019134.2.

    Genome annotation databases

    EnsemblFungiiSPAC13G7.01c.1; SPAC13G7.01c.1:pep; SPAC13G7.01c.
    GeneIDi2542882.
    KEGGispo:SPAC13G7.01c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41368 mRNA. Translation: AAA92502.1 .
    CU329670 Genomic DNA. Translation: CAA93571.1 .
    PIRi JC4643.
    RefSeqi NP_593702.2. NM_001019134.2.

    3D structure databases

    ProteinModelPortali Q10231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4697960.
    STRINGi 4896.SPAC13G7.01c-1.

    Proteomic databases

    MaxQBi Q10231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC13G7.01c.1 ; SPAC13G7.01c.1:pep ; SPAC13G7.01c .
    GeneIDi 2542882.
    KEGGi spo:SPAC13G7.01c.

    Organism-specific databases

    PomBasei SPAC13G7.01c.

    Phylogenomic databases

    eggNOGi COG1657.
    HOGENOMi HOG000234317.
    KOi K01852.
    OMAi TNGLQVW.
    OrthoDBi EOG70610B.
    PhylomeDBi Q10231.

    Enzyme and pathway databases

    UniPathwayi UPA00767 ; UER00753 .

    Miscellaneous databases

    NextBioi 20803922.
    PROi Q10231.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues."
      Corey E.J., Matsuda S.P.T., Baker C.H., Ting A.Y., Cheng H.
      Biochem. Biophys. Res. Commun. 219:327-331(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiERG7_SCHPO
    AccessioniPrimary (citable) accession number: Q10231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3