Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein 3

Gene

btb3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 3
Gene namesi
Name:btb3
ORF Names:SPAC13D6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.04c.
PomBaseiSPAC13D6.04c. btb3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • SCF ubiquitin ligase complex Source: GO_Central
  • ubiquitin ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000672481 – 523BTB/POZ domain-containing protein 3Add BLAST523

Post-translational modificationi

Ubiquitinated and targeted for cul3-dependent degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ10225.
PRIDEiQ10225.

Interactioni

Subunit structurei

Interacts with cul3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097604EBI-3648208,EBI-3647930

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279317. 3 interactors.
IntActiQ10225. 2 interactors.
MINTiMINT-4697939.

Structurei

3D structure databases

ProteinModelPortaliQ10225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 114ANKAdd BLAST30
Domaini167 – 223BTB 1PROSITE-ProRule annotationAdd BLAST57
Domaini306 – 373BTB 2PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 ANK repeat.Curated
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000202106.
InParanoidiQ10225.
KOiK06867.
OMAiFLYTERA.
OrthoDBiEOG092C2ZQF.
PhylomeDBiQ10225.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50097. BTB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQDQNTGT THVELQGGEN SKKLFSKYDL WSKAMDEKKL SSSLFTVNDT
60 70 80 90 100
QEFLELCEAC RRGDLEVVKS LVENYNTPIN QVDQFDYSPL VLASLCGHEP
110 120 130 140 150
VVKFLLENGA LCERDTFQGE RCLYGALNDN IRRMLLSYDI TKAIDESQPY
160 170 180 190 200
ASHITSLLSN SALHFTTDIV FAGQYGRVFA HKFYLAARSS YFKSKFSKLG
210 220 230 240 250
PSEHEIEVKH FAKEFESILR YLYLDTNAVF TKQYNNALLS IGKKFQLNDF
260 270 280 290 300
IALYEKDREQ LHSRDWKKIQ LAKTQNDLGE FLDYIISNYK VPIESLNQPS
310 320 330 340 350
DQYSFHDAYL QSYTHRYPVH RAIMCRCEYF LDMLAGPFLE SNQELPVLSL
360 370 380 390 400
PFSSSVVEIV LKFLYTDKTD IAPELALDVV YVADMLSLDK DRSLKSLASI
410 420 430 440 450
VITKQEEPID SIYDILRTAW DTSTPRLEQY ASEYMANHLE HLIDDPEFCE
460 470 480 490 500
LVKESADRIL QRQETDTIEL IDDIRYFLSK RFGIYHEDLC IDGVVDTLTP
510 520
YESEYNQKME MIDDLLDKLE LQA
Length:523
Mass (Da):60,445
Last modified:October 1, 1996 - v1
Checksum:iB565690ECCBF6A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93544.1.
PIRiT37624.
RefSeqiNP_593682.1. NM_001019114.2.

Genome annotation databases

EnsemblFungiiSPAC13D6.04c.1; SPAC13D6.04c.1:pep; SPAC13D6.04c.
GeneIDi2542872.
KEGGispo:SPAC13D6.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93544.1.
PIRiT37624.
RefSeqiNP_593682.1. NM_001019114.2.

3D structure databases

ProteinModelPortaliQ10225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279317. 3 interactors.
IntActiQ10225. 2 interactors.
MINTiMINT-4697939.

Proteomic databases

MaxQBiQ10225.
PRIDEiQ10225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13D6.04c.1; SPAC13D6.04c.1:pep; SPAC13D6.04c.
GeneIDi2542872.
KEGGispo:SPAC13D6.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.04c.
PomBaseiSPAC13D6.04c. btb3.

Phylogenomic databases

HOGENOMiHOG000202106.
InParanoidiQ10225.
KOiK06867.
OMAiFLYTERA.
OrthoDBiEOG092C2ZQF.
PhylomeDBiQ10225.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ10225.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00651. BTB. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50097. BTB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTB3_SCHPO
AccessioniPrimary (citable) accession number: Q10225
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.