Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein 3

Gene

btb3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 3
Gene namesi
Name:btb3
ORF Names:SPAC13D6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.04c
PomBaseiSPAC13D6.04c btb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000672481 – 523BTB/POZ domain-containing protein 3Add BLAST523

Post-translational modificationi

Ubiquitinated and targeted for cul3-dependent degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ10225
PaxDbiQ10225
PRIDEiQ10225

Interactioni

Subunit structurei

Interacts with cul3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097604EBI-3648208,EBI-3647930

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279317, 3 interactors
IntActiQ10225, 2 interactors
STRINGi4896.SPAC13D6.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ10225
SMRiQ10225
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 114ANKAdd BLAST30
Domaini167 – 223BTB 1PROSITE-ProRule annotationAdd BLAST57
Domaini306 – 373BTB 2PROSITE-ProRule annotationAdd BLAST68

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000202106
InParanoidiQ10225
KOiK06867
OMAiMLDTKWK
OrthoDBiEOG092C2ZQF
PhylomeDBiQ10225

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 2 hits
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50097 BTB, 2 hits

Sequencei

Sequence statusi: Complete.

Q10225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQDQNTGT THVELQGGEN SKKLFSKYDL WSKAMDEKKL SSSLFTVNDT
60 70 80 90 100
QEFLELCEAC RRGDLEVVKS LVENYNTPIN QVDQFDYSPL VLASLCGHEP
110 120 130 140 150
VVKFLLENGA LCERDTFQGE RCLYGALNDN IRRMLLSYDI TKAIDESQPY
160 170 180 190 200
ASHITSLLSN SALHFTTDIV FAGQYGRVFA HKFYLAARSS YFKSKFSKLG
210 220 230 240 250
PSEHEIEVKH FAKEFESILR YLYLDTNAVF TKQYNNALLS IGKKFQLNDF
260 270 280 290 300
IALYEKDREQ LHSRDWKKIQ LAKTQNDLGE FLDYIISNYK VPIESLNQPS
310 320 330 340 350
DQYSFHDAYL QSYTHRYPVH RAIMCRCEYF LDMLAGPFLE SNQELPVLSL
360 370 380 390 400
PFSSSVVEIV LKFLYTDKTD IAPELALDVV YVADMLSLDK DRSLKSLASI
410 420 430 440 450
VITKQEEPID SIYDILRTAW DTSTPRLEQY ASEYMANHLE HLIDDPEFCE
460 470 480 490 500
LVKESADRIL QRQETDTIEL IDDIRYFLSK RFGIYHEDLC IDGVVDTLTP
510 520
YESEYNQKME MIDDLLDKLE LQA
Length:523
Mass (Da):60,445
Last modified:October 1, 1996 - v1
Checksum:iB565690ECCBF6A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93544.1
PIRiT37624
RefSeqiNP_593682.1, NM_001019114.2

Genome annotation databases

EnsemblFungiiSPAC13D6.04c.1; SPAC13D6.04c.1:pep; SPAC13D6.04c
GeneIDi2542872
KEGGispo:SPAC13D6.04c

Similar proteinsi

Entry informationi

Entry nameiBTB3_SCHPO
AccessioniPrimary (citable) accession number: Q10225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health