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Protein

tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

Gene

trm9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the methylation of the wobble bases at position 34 in tRNA. Appears to have a role in stress-response (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + carboxymethyluridine(34) in tRNA = S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase (EC:2.1.1.229)
Alternative name(s):
tRNA (uracil-5-)-methyltransferase trm9
tRNA [Um34] methyltransferase
tRNA methylase 9
Gene namesi
Name:trm9
ORF Names:SPAC13D6.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.03c.
PomBaseiSPAC13D6.03c. trm9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228tRNA (carboxymethyluridine(34)-5-O)-methyltransferasePRO_0000116489Add
BLAST

Proteomic databases

MaxQBiQ10224.

Interactioni

Protein-protein interaction databases

BioGridi279350. 4 interactions.
MINTiMINT-4697931.

Structurei

3D structure databases

ProteinModelPortaliQ10224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000209191.
InParanoidiQ10224.
KOiK15444.
OMAiYEATHVH.
OrthoDBiEOG092C4H6Z.
PhylomeDBiQ10224.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIEYENEYV HQVYDKIATH FSDTRYKPWP VVEKFLKSLP LGSVGVDIGC
60 70 80 90 100
GNGKYQKVNP NVYMIGSDRC VKLVKIASNL GPMVISDGLH VPHPSNRFDF
110 120 130 140 150
ALSIAVIHHF SNENRRLQAV QEVLRPLVKG GKALFFVWAL EQKNSRRGFS
160 170 180 190 200
EDGPQDVYVP WILKRQYEYP NAKPEELKGH DPAENIAYQR YYHLFRKGEL
210 220
NELVETAGGS ILEHGYDRDN WWVIAEKN
Length:228
Mass (Da):26,277
Last modified:October 1, 1996 - v1
Checksum:i05CC5AD1A53B8C9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93543.1.
PIRiT37623.
RefSeqiNP_593681.1. NM_001019113.2.

Genome annotation databases

EnsemblFungiiSPAC13D6.03c.1; SPAC13D6.03c.1:pep; SPAC13D6.03c.
GeneIDi2542906.
KEGGispo:SPAC13D6.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93543.1.
PIRiT37623.
RefSeqiNP_593681.1. NM_001019113.2.

3D structure databases

ProteinModelPortaliQ10224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279350. 4 interactions.
MINTiMINT-4697931.

Proteomic databases

MaxQBiQ10224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13D6.03c.1; SPAC13D6.03c.1:pep; SPAC13D6.03c.
GeneIDi2542906.
KEGGispo:SPAC13D6.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC13D6.03c.
PomBaseiSPAC13D6.03c. trm9.

Phylogenomic databases

HOGENOMiHOG000209191.
InParanoidiQ10224.
KOiK15444.
OMAiYEATHVH.
OrthoDBiEOG092C4H6Z.
PhylomeDBiQ10224.

Miscellaneous databases

PROiQ10224.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRM9_SCHPO
AccessioniPrimary (citable) accession number: Q10224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.