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Protein

Putative acyl carrier protein, mitochondrial

Gene

SPAC4H3.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids.By similarity

Caution

Was previously considered as a subunit of the NADH dehydrogenase of the mitochondrial respiratory chain complex I. Due to lack of 38 of the other 40 subunits that are present in that complex in mammals, this attribution is unlikely (PubMed:1518044).Curated

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiR-SPO-389661 Glyoxylate metabolism and glycine degradation
R-SPO-77289 Mitochondrial Fatty Acid Beta-Oxidation
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyl carrier protein, mitochondrial
Short name:
ACP
Gene namesi
ORF Names:SPAC4H3.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4H3.09
PomBaseiSPAC4H3.09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000000056529 – 112Putative acyl carrier protein, mitochondrialAdd BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ10217
PaxDbiQ10217
PRIDEiQ10217

PTM databases

iPTMnetiQ10217

Interactioni

Protein-protein interaction databases

BioGridi279978, 1 interactor
STRINGi4896.SPAC4H3.09.1

Structurei

3D structure databases

ProteinModelPortaliQ10217
SMRiQ10217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 109CarrierPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000178184
InParanoidiQ10217
KOiK03955
OMAiTVEVIMA
OrthoDBiEOG092C5SMT
PhylomeDBiQ10217

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRFSSQLR FISAVRPVIP KFQPLRFYSV ARPDAEKRIL KVVSSFDKIQ
60 70 80 90 100
DPKKVTPTST FANDLGLDSL DAVEVVMAIE EEFSIQIPDK DADEITSVGD
110
AISYITKNPE AK
Length:112
Mass (Da):12,519
Last modified:October 1, 1996 - v1
Checksum:i969C777F3622FE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93348.1
PIRiT38889
RefSeqiNP_594345.1, NM_001019766.2

Genome annotation databases

EnsemblFungiiSPAC4H3.09.1; SPAC4H3.09.1:pep; SPAC4H3.09
GeneIDi2543562
KEGGispo:SPAC4H3.09

Similar proteinsi

Entry informationi

Entry nameiACPM_SCHPO
AccessioniPrimary (citable) accession number: Q10217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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