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Protein

Putative acyl carrier protein, mitochondrial

Gene

SPAC4H3.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-77289. Mitochondrial Fatty Acid Beta-Oxidation.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyl carrier protein, mitochondrial
Short name:
ACP
Gene namesi
ORF Names:SPAC4H3.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4H3.09.
PomBaseiSPAC4H3.09.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000000056529 – 112Putative acyl carrier protein, mitochondrialAdd BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69O-(pantetheine 4'-phosphoryl)serineSequence analysis1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ10217.
PRIDEiQ10217.

Interactioni

Protein-protein interaction databases

BioGridi279978. 1 interactor.
MINTiMINT-4697883.

Structurei

3D structure databases

ProteinModelPortaliQ10217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000178184.
InParanoidiQ10217.
KOiK03955.
OMAiFVKPIRF.
OrthoDBiEOG092C5SMT.
PhylomeDBiQ10217.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRFSSQLR FISAVRPVIP KFQPLRFYSV ARPDAEKRIL KVVSSFDKIQ
60 70 80 90 100
DPKKVTPTST FANDLGLDSL DAVEVVMAIE EEFSIQIPDK DADEITSVGD
110
AISYITKNPE AK
Length:112
Mass (Da):12,519
Last modified:October 1, 1996 - v1
Checksum:i969C777F3622FE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93348.1.
PIRiT38889.
RefSeqiNP_594345.1. NM_001019766.2.

Genome annotation databases

EnsemblFungiiSPAC4H3.09.1; SPAC4H3.09.1:pep; SPAC4H3.09.
GeneIDi2543562.
KEGGispo:SPAC4H3.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93348.1.
PIRiT38889.
RefSeqiNP_594345.1. NM_001019766.2.

3D structure databases

ProteinModelPortaliQ10217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279978. 1 interactor.
MINTiMINT-4697883.

Proteomic databases

MaxQBiQ10217.
PRIDEiQ10217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4H3.09.1; SPAC4H3.09.1:pep; SPAC4H3.09.
GeneIDi2543562.
KEGGispo:SPAC4H3.09.

Organism-specific databases

EuPathDBiFungiDB:SPAC4H3.09.
PomBaseiSPAC4H3.09.

Phylogenomic databases

HOGENOMiHOG000178184.
InParanoidiQ10217.
KOiK03955.
OMAiFVKPIRF.
OrthoDBiEOG092C5SMT.
PhylomeDBiQ10217.

Enzyme and pathway databases

UniPathwayiUPA00094.
ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Miscellaneous databases

PROiQ10217.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACPM_SCHPO
AccessioniPrimary (citable) accession number: Q10217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Was previously considered as a subunit of the NADH dehydrogenase of the mitochondrial respiratory chain complex I. Due to lack of 38 of the other 40 subunits that are present in that complex in mammals, this attribution is unlikely (PubMed:1518044).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.