Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent RNA helicase dbp3

Gene

dbp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 216ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase dbp3 (EC:3.6.4.13)
Gene namesi
Name:dbp3
ORF Names:SPBC17D1.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17D1.06.
PomBaseiSPBC17D1.06. dbp3.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550881 – 578ATP-dependent RNA helicase dbp3Add BLAST578

Proteomic databases

MaxQBiQ10202.
PRIDEiQ10202.

PTM databases

SwissPalmiQ10202.

Interactioni

Protein-protein interaction databases

BioGridi276746. 11 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ10202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 373Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST178
Domaini402 – 550Helicase C-terminalPROSITE-ProRule annotationAdd BLAST149

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi167 – 193Q motifAdd BLAST27
Motifi316 – 319DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000268804.
InParanoidiQ10202.
KOiK14811.
OMAiPIQSASW.
OrthoDBiEOG092C1B4A.
PhylomeDBiQ10202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFCFRILIL YISLSIDNNY LVTTLISLKE NVFLHIFTLT FLFKAFLLKM
60 70 80 90 100
AKRSVEELKR SADEEASVKR KEKKSKHEHK KHKKDKPSAD KDRISKKDKK
110 120 130 140 150
KSKKGKSKTK EESIEINAEE GAKIAQPAIG SANASNHNDE EAYDRYIKKH
160 170 180 190 200
NISFADPKSS ENLLPILQFD ELDVSAKLRE GLKNYKEPTP IQAATWPYLL
210 220 230 240 250
AGRDVVGIAE TGSGKTVAFG IPALQYLNGL SDNKSVPRVL VVSPTRELAI
260 270 280 290 300
QTYENLNSLI QGTNLKAVVV YGGAPKSEQA RAAKNASVII GTPGRLLDLI
310 320 330 340 350
NDGSIDCSQV GYLVLDEADR MLDTGFEQDI RNIISHTPDP TRNGSRQTVF
360 370 380 390 400
FSATWPESVR ALAATFLKDP VKITIGSDEL AASQNITQIV EILDDPRSKE
410 420 430 440 450
RMLDNLLRKH LSSGGKDDKI LIFVLYKKEA ARVEGTLARK YNVVGIHGDM
460 470 480 490 500
SQGARLQALN DFKSGKCPVL VATDVAARGL DIPKVQLVIN VTFPLTIEDY
510 520 530 540 550
VHRIGRTGRA NTKGTAITFF TPQDKSHAGE LVNVLRQAKQ DIPEGLFKFG
560 570
TAVKPKLNAY GSRVVDVPVK AATKIVFD
Length:578
Mass (Da):63,912
Last modified:October 1, 1996 - v1
Checksum:i0A84EC77ECCC29FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20430.1.
PIRiT39709. S67386.
RefSeqiNP_596388.1. NM_001022309.2.

Genome annotation databases

EnsemblFungiiSPBC17D1.06.1; SPBC17D1.06.1:pep; SPBC17D1.06.
GeneIDi2540213.
KEGGispo:SPBC17D1.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20430.1.
PIRiT39709. S67386.
RefSeqiNP_596388.1. NM_001022309.2.

3D structure databases

ProteinModelPortaliQ10202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276746. 11 interactors.

PTM databases

SwissPalmiQ10202.

Proteomic databases

MaxQBiQ10202.
PRIDEiQ10202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC17D1.06.1; SPBC17D1.06.1:pep; SPBC17D1.06.
GeneIDi2540213.
KEGGispo:SPBC17D1.06.

Organism-specific databases

EuPathDBiFungiDB:SPBC17D1.06.
PomBaseiSPBC17D1.06. dbp3.

Phylogenomic databases

HOGENOMiHOG000268804.
InParanoidiQ10202.
KOiK14811.
OMAiPIQSASW.
OrthoDBiEOG092C1B4A.
PhylomeDBiQ10202.

Miscellaneous databases

PROiQ10202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP3_SCHPO
AccessioniPrimary (citable) accession number: Q10202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.