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Protein

Kinetochore protein ndc80

Gene

ndc80

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of mitotic cell cycle spindle assembly checkpoint Source: PomBase
  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
  • cell division Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein ndc80
Alternative name(s):
NMS complex subunit ndc80
Gene namesi
Name:ndc80
Synonyms:ndc10, tid3
ORF Names:SPBC11C11.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC11C11.03
PomBaseiSPBC11C11.03 ndc80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001165331 – 624Kinetochore protein ndc80Add BLAST624

Proteomic databases

MaxQBiQ10198
PaxDbiQ10198
PRIDEiQ10198

Interactioni

Subunit structurei

Component of the NDC80 complex, which consists of ndc80, nuf2, spc24 and spc25. Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276635, 13 interactors
IntActiQ10198, 4 interactors
STRINGi4896.SPBC11C11.03.1

Structurei

3D structure databases

ProteinModelPortaliQ10198
SMRiQ10198
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili263 – 399Sequence analysisAdd BLAST137
Coiled coili484 – 560Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the NDC80/HEC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ10198
KOiK11547
OMAiKSPTQKD
OrthoDBiEOG092C1AHP
PhylomeDBiQ10198

Family and domain databases

Gene3Di1.10.418.30, 1 hit
InterProiView protein in InterPro
IPR005550 Kinetochore_Ndc80
IPR038273 Ndc80_sf
PANTHERiPTHR10643 PTHR10643, 1 hit
PfamiView protein in Pfam
PF03801 Ndc80_HEC, 1 hit

Sequencei

Sequence statusi: Complete.

Q10198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDSSSYARR YSQAPSSSNL RTTTFGFNGL GTSRTSLAPQ RTLVNARQSI
60 70 80 90 100
DPDGLSSRVL TPTMRPSLAP NTRRSSVRVS NASFISQTPN ITSIKDPRPL
110 120 130 140 150
SDRRYQQECA TQVVNYLLES GFSQPLGLNN RFMPSTREFA AIFKHLYNKL
160 170 180 190 200
DPNFRFGARY EEDVTTCLKA LNYPFLDSIS RSRLVAIGSP HVWPAILGML
210 220 230 240 250
HWVVSLIQCT EKAVAMVYTV EQNSLDDHLV DKVLFDYLVR TYHLYLDESP
260 270 280 290 300
EESEPEKELK ATFNQQNQDL YNQTEALKST NEELINQIKS AEELDSAIQV
310 320 330 340 350
LEERYRTMQR DEVKFQSAMS GMKSKMESRT NLMKQLQVNI EEKESQLQLL
360 370 380 390 400
KEKRDSLKYQ VENQDISISE FEKMVSEREQ LDRNLNMIGS KISELRKEVF
410 420 430 440 450
DTDLLIQASI DSLEKKVQKF NSLAYRIGIV PIAAIRSANN DFELEINPEG
460 470 480 490 500
PNYINLDLKN KVRPFINEVR RSITLEFHEE QNKSLKLQEH VDTVNDLIAE
510 520 530 540 550
LQDELRGIES RLTSVLSECN MLRETASEEK NAFDAESDKL ERELQQLKLS
560 570 580 590 600
SHNSMLQLDQ RIQSINIEAD QIAHACMEYK NNIYKEVAFV LGEIIHFKLH
610 620
VQDSLEDLKM DYQKELDDLS RSEL
Length:624
Mass (Da):71,859
Last modified:October 1, 1996 - v1
Checksum:i82EEC220635F5E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA20685.1
PIRiT39318 S67382
RefSeqiNP_596392.1, NM_001022313.2

Genome annotation databases

EnsemblFungiiSPBC11C11.03.1; SPBC11C11.03.1:pep; SPBC11C11.03
GeneIDi2540097
KEGGispo:SPBC11C11.03

Similar proteinsi

Entry informationi

Entry nameiNDC80_SCHPO
AccessioniPrimary (citable) accession number: Q10198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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