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Protein

Kinetochore protein ndc80

Gene

ndc80

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein ndc80
Alternative name(s):
NMS complex subunit ndc80
Gene namesi
Name:ndc80
Synonyms:ndc10, tid3
ORF Names:SPBC11C11.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC11C11.03.
PomBaseiSPBC11C11.03. ndc80.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: PomBase
  • condensed nuclear chromosome kinetochore Source: PomBase
  • condensed nuclear chromosome outer kinetochore Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • Ndc80 complex Source: PomBase
  • NMS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001165331 – 624Kinetochore protein ndc80Add BLAST624

Proteomic databases

MaxQBiQ10198.
PRIDEiQ10198.

Interactioni

Subunit structurei

Component of the NDC80 complex, which consists of ndc80, nuf2, spc24 and spc25. Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
nuf2Q101733EBI-1002524,EBI-1002565
spc24Q9UST63EBI-1002524,EBI-1002585

Protein-protein interaction databases

BioGridi276635. 9 interactors.
IntActiQ10198. 4 interactors.
MINTiMINT-4697714.

Structurei

3D structure databases

ProteinModelPortaliQ10198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili263 – 399Sequence analysisAdd BLAST137
Coiled coili484 – 560Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the NDC80/HEC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ10198.
KOiK11547.
OMAiDEKCASE.
OrthoDBiEOG092C1AHP.
PhylomeDBiQ10198.

Family and domain databases

InterProiIPR005550. Kinetochore_Ndc80.
[Graphical view]
PANTHERiPTHR10643. PTHR10643. 1 hit.
PfamiPF03801. Ndc80_HEC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDSSSYARR YSQAPSSSNL RTTTFGFNGL GTSRTSLAPQ RTLVNARQSI
60 70 80 90 100
DPDGLSSRVL TPTMRPSLAP NTRRSSVRVS NASFISQTPN ITSIKDPRPL
110 120 130 140 150
SDRRYQQECA TQVVNYLLES GFSQPLGLNN RFMPSTREFA AIFKHLYNKL
160 170 180 190 200
DPNFRFGARY EEDVTTCLKA LNYPFLDSIS RSRLVAIGSP HVWPAILGML
210 220 230 240 250
HWVVSLIQCT EKAVAMVYTV EQNSLDDHLV DKVLFDYLVR TYHLYLDESP
260 270 280 290 300
EESEPEKELK ATFNQQNQDL YNQTEALKST NEELINQIKS AEELDSAIQV
310 320 330 340 350
LEERYRTMQR DEVKFQSAMS GMKSKMESRT NLMKQLQVNI EEKESQLQLL
360 370 380 390 400
KEKRDSLKYQ VENQDISISE FEKMVSEREQ LDRNLNMIGS KISELRKEVF
410 420 430 440 450
DTDLLIQASI DSLEKKVQKF NSLAYRIGIV PIAAIRSANN DFELEINPEG
460 470 480 490 500
PNYINLDLKN KVRPFINEVR RSITLEFHEE QNKSLKLQEH VDTVNDLIAE
510 520 530 540 550
LQDELRGIES RLTSVLSECN MLRETASEEK NAFDAESDKL ERELQQLKLS
560 570 580 590 600
SHNSMLQLDQ RIQSINIEAD QIAHACMEYK NNIYKEVAFV LGEIIHFKLH
610 620
VQDSLEDLKM DYQKELDDLS RSEL
Length:624
Mass (Da):71,859
Last modified:October 1, 1996 - v1
Checksum:i82EEC220635F5E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20685.1.
PIRiT39318. S67382.
RefSeqiNP_596392.1. NM_001022313.2.

Genome annotation databases

EnsemblFungiiSPBC11C11.03.1; SPBC11C11.03.1:pep; SPBC11C11.03.
GeneIDi2540097.
KEGGispo:SPBC11C11.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20685.1.
PIRiT39318. S67382.
RefSeqiNP_596392.1. NM_001022313.2.

3D structure databases

ProteinModelPortaliQ10198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276635. 9 interactors.
IntActiQ10198. 4 interactors.
MINTiMINT-4697714.

Proteomic databases

MaxQBiQ10198.
PRIDEiQ10198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC11C11.03.1; SPBC11C11.03.1:pep; SPBC11C11.03.
GeneIDi2540097.
KEGGispo:SPBC11C11.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC11C11.03.
PomBaseiSPBC11C11.03. ndc80.

Phylogenomic databases

InParanoidiQ10198.
KOiK11547.
OMAiDEKCASE.
OrthoDBiEOG092C1AHP.
PhylomeDBiQ10198.

Miscellaneous databases

PROiQ10198.

Family and domain databases

InterProiIPR005550. Kinetochore_Ndc80.
[Graphical view]
PANTHERiPTHR10643. PTHR10643. 1 hit.
PfamiPF03801. Ndc80_HEC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDC80_SCHPO
AccessioniPrimary (citable) accession number: Q10198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.