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Protein

Large subunit GTPase 1

Gene

lsg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GTPase required for the nuclear export of the 60S ribosomal subunit. Acts by mediating the release of nmd3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2124GTPSequence analysis
Nucleotide bindingi308 – 3158GTPSequence analysis
Nucleotide bindingi352 – 3554GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large subunit GTPase 1 (EC:3.6.1.-)
Gene namesi
Name:lsg1
ORF Names:SPAC3F10.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3F10.16c.
PomBaseiSPAC3F10.16c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Large subunit GTPase 1PRO_0000122453Add
BLAST

Proteomic databases

MaxQBiQ10190.

Interactioni

Protein-protein interaction databases

MINTiMINT-4697640.

Structurei

3D structure databases

ProteinModelPortaliQ10190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 359199CP-type GPROSITE-ProRule annotationAdd
BLAST

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000172552.
InParanoidiQ10190.
KOiK14539.
OMAiYTINHSS.
OrthoDBiEOG7SN8N7.
PhylomeDBiQ10190.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPKSKNQI GLGRAIQSDF TKNRRNRKGG LKHIVDSDPK AHRAALRSVT
60 70 80 90 100
HETDLDEFLN TAELGEVEFI AEKQNVTVIQ NPEQNPFLLS KEEAARSKQK
110 120 130 140 150
QEKNKDRLTI PRRPHWDQTT TAVELDRMER ESFLNWRRNL AQLQDVEGFI
160 170 180 190 200
VTPFERNLEI WRQLWRVIER SDVVVQIVDA RNPLFFRSAH LEQYVKEVGP
210 220 230 240 250
SKKNFLLVNK ADMLTEEQRN YWSSYFNENN IPFLFFSARM AAEANERGED
260 270 280 290 300
LETYESTSSN EIPESLQADE NDVHSSRIAT LKVLEGIFEK FASTLPDGKT
310 320 330 340 350
KMTFGLVGYP NVGKSSTINA LVGSKKVSVS STPGKTKHFQ TINLSEKVSL
360 370 380 390 400
LDCPGLVFPS FATTQADLVL DGVLPIDQLR EYTGPSALMA ERIPKEVLET
410 420 430 440 450
LYTIRIRIKP IEEGGTGVPS AQEVLFPFAR SRGFMRAHHG TPDDSRAARI
460 470 480 490 500
LLKDYVNGKL LYVHPPPNYP NSGSEFNKEH HQKIVSATSD SITEKLQRTA
510 520 530 540 550
ISDNTLSAES QLVDDEYFQE NPHVRPMVKG TAVAMQGPVY KGRNTMQPFQ
560 570 580 590 600
RRLNDDASPK YPMNAQGKPL SRRKARQLTA LELGVSPEAL SSATSKKHNK
610
KNKRSKQRSG VVIDDY
Length:616
Mass (Da):69,675
Last modified:October 1, 1996 - v1
Checksum:iF02A2996AF06FB68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93314.1.
PIRiT38717.
RefSeqiNP_593948.1. NM_001019375.2.

Genome annotation databases

EnsemblFungiiSPAC3F10.16c.1; SPAC3F10.16c.1:pep; SPAC3F10.16c.
GeneIDi2541449.
KEGGispo:SPAC3F10.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93314.1.
PIRiT38717.
RefSeqiNP_593948.1. NM_001019375.2.

3D structure databases

ProteinModelPortaliQ10190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4697640.

Proteomic databases

MaxQBiQ10190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3F10.16c.1; SPAC3F10.16c.1:pep; SPAC3F10.16c.
GeneIDi2541449.
KEGGispo:SPAC3F10.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC3F10.16c.
PomBaseiSPAC3F10.16c.

Phylogenomic databases

HOGENOMiHOG000172552.
InParanoidiQ10190.
KOiK14539.
OMAiYTINHSS.
OrthoDBiEOG7SN8N7.
PhylomeDBiQ10190.

Miscellaneous databases

NextBioi20802551.
PROiQ10190.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiLSG1_SCHPO
AccessioniPrimary (citable) accession number: Q10190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.