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Protein

Probable peptidyl-prolyl cis-trans isomerase C27F1.06c

Gene

SPAC27F1.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-prolyl cis-trans isomerase C27F1.06c (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
ORF Names:SPAC27F1.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27F1.06c.
PomBaseiSPAC27F1.06c.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • nucleolus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Probable peptidyl-prolyl cis-trans isomerase C27F1.06cPRO_0000075316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691Phosphoserine1 Publication
Modified residuei177 – 1771Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10175.

PTM databases

iPTMnetiQ10175.

Interactioni

Protein-protein interaction databases

BioGridi277981. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ10175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini276 – 36287PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000216214.
InParanoidiQ10175.
KOiK14826.
OMAiPRAKSND.
OrthoDBiEOG092C52SD.
PhylomeDBiQ10175.

Family and domain databases

InterProiIPR026257. FK506_BP.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001473. FK506-bp_FPR3. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEETLYSV KVDQERVPLF DEDFYKGFRS ELSVRFTMAA LDPRAKSNDA
60 70 80 90 100
VTVNVITRLE HPEEDGEESD EELFQEEKFT LCTLKKGSVY QQPIDIIFSP
110 120 130 140 150
GEEVFFERVG GDIPVYLSGT CIITNIPEEE DSSDLENDFL YGADEFSSDE
160 170 180 190 200
EEMDDISVTS SEEEEEENGA RIEELNSDEE DAEQAEEEIL EKPVPKDEVA
210 220 230 240 250
EKHSKDKLKK EEKEKKTAVD VSDSVNGKKR KTEPAGEGEQ TEKKSKSTKT
260 270 280 290 300
YPKQVLEGNV TVQDKVKGDG PAAKRKKRVS MRYIGRLTNG KVFDKNITGK
310 320 330 340 350
PFTFNLGLEE VIKGWDVGIV GMQVGGERTI HIPAAMAYGS KRLPGIPANS
360
DLVFDVKLLA VN
Length:362
Mass (Da):40,540
Last modified:October 1, 1996 - v1
Checksum:i88F1785FB95A7B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93295.1.
PIRiT38464.
RefSeqiNP_594535.1. NM_001019964.2.

Genome annotation databases

EnsemblFungiiSPAC27F1.06c.1; SPAC27F1.06c.1:pep; SPAC27F1.06c.
GeneIDi2541479.
KEGGispo:SPAC27F1.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93295.1.
PIRiT38464.
RefSeqiNP_594535.1. NM_001019964.2.

3D structure databases

ProteinModelPortaliQ10175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277981. 19 interactions.

PTM databases

iPTMnetiQ10175.

Proteomic databases

MaxQBiQ10175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC27F1.06c.1; SPAC27F1.06c.1:pep; SPAC27F1.06c.
GeneIDi2541479.
KEGGispo:SPAC27F1.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC27F1.06c.
PomBaseiSPAC27F1.06c.

Phylogenomic databases

HOGENOMiHOG000216214.
InParanoidiQ10175.
KOiK14826.
OMAiPRAKSND.
OrthoDBiEOG092C52SD.
PhylomeDBiQ10175.

Miscellaneous databases

PROiQ10175.

Family and domain databases

InterProiIPR026257. FK506_BP.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001473. FK506-bp_FPR3. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBPH_SCHPO
AccessioniPrimary (citable) accession number: Q10175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.