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Protein

Actin cytoskeleton-regulatory complex protein pan1

Gene

pan1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.
R-SPO-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin cytoskeleton-regulatory complex protein pan1
Gene namesi
Name:pan1
ORF Names:SPAC25G10.09c, SPAC27F1.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.09c.
PomBaseiSPAC25G10.09c. pan1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • cell cortex Source: PomBase
  • endosome membrane Source: UniProtKB-SubCell
  • nucleus Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001166091 – 1794Actin cytoskeleton-regulatory complex protein pan1Add BLAST1794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152Phosphothreonine1 Publication1
Modified residuei706Phosphothreonine1 Publication1
Modified residuei1219Phosphoserine1 Publication1
Modified residuei1221Phosphoserine1 Publication1
Modified residuei1406Phosphoserine1 Publication1
Modified residuei1409Phosphoserine1 Publication1
Modified residuei1412Phosphoserine1 Publication1
Modified residuei1414Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10172.
PRIDEiQ10172.

PTM databases

iPTMnetiQ10172.

Interactioni

Subunit structurei

Component of the PAN1 actin cytoskeleton-regulatory complex.By similarity

Protein-protein interaction databases

BioGridi858093. 6 interactors.
MINTiMINT-4697464.

Structurei

3D structure databases

ProteinModelPortaliQ10172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 369EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini821 – 910EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini1748 – 1765WH2PROSITE-ProRule annotationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1107 – 1151Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 749Gln-richAdd BLAST717
Compositional biasi1302 – 1746Pro-richAdd BLAST445

Sequence similaritiesi

Belongs to the PAN1 family.Curated
Contains 2 EH domains.PROSITE-ProRule annotation
Contains 1 WH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

InParanoidiQ10172.
KOiK20047.
OMAiPQRTGMQ.
OrthoDBiEOG092C25IB.
PhylomeDBiQ10172.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR013182. DUF1720.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR026812. Pan1.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR11216:SF79. PTHR11216:SF79. 5 hits.
PfamiPF08226. DUF1720. 4 hits.
PF12763. EF-hand_4. 2 hits.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00027. EH. 2 hits.
SM00246. WH2. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPNQMNGS MYGYGANNGV QPGFDSYGMP INQGGMNYQQ QTYPYQQPYQ
60 70 80 90 100
PDGYAGNTML PFQQSQPATQ FNNGFGYASQ PTGSVADYGQ QQQQMYGYNG
110 120 130 140 150
MMPQTMNNTG FMQPQQTGAI PGFAPQPTGF VQPQPTGFMS QQPASFMQPQ
160 170 180 190 200
RTGGAGFIQP QRTGAMPAYQ PQMNNFMQPQ KTGGFAPQAT GFMQTQPFGA
210 220 230 240 250
APSFAPQPTG FVQPQQTGVV MPPQPTGYLQ AQPTGPFASF VQPQQTASFM
260 270 280 290 300
PAAQPLKPQK TGQIHNSKAM DTRLSFVSAA DQAKFEQLFK SAVGREEAMS
310 320 330 340 350
SEIGKAILVR SKLPTVQLSK IWRLSDTTRS GRLLFPQFVL AMYLCNLGLT
360 370 380 390 400
GKPIPDKVPD GILNEVNAMV DAISFSLDEN YAKPTQPIPQ AAAQQMAAQM
410 420 430 440 450
FGGFQQAAGI PSQITGFQPQ AMMPQRTGMQ PQMTGFQQPM IPQRTGMQPQ
460 470 480 490 500
MTGFQQPMMP QRTGLQPQMT GFQQPMVPQR TGMQPQMTGF QQPMMPQRTG
510 520 530 540 550
LQPQMTGFQQ PMVPQRTGMQ PMMPGLQQPM APQRTGMQPM MPQRTGMQPQ
560 570 580 590 600
MTGFQQPMAP QRTGMQPMMP QRTGMQPQMP GMQQPMAPQR TGMQPMMPQR
610 620 630 640 650
TGMQQPMAPQ RTGMQPMMPQ RTGMQPQMPG MQQPMAPQRT GMQPMMPQRT
660 670 680 690 700
GMQPQMPGMQ QPMAPQRTGM QPMAPQRTGM QPMMPQRTGM QPQMPGMQQP
710 720 730 740 750
MAPQRTGMQP MMPQRTGMQP QMPGMQQPMA PQRTGMQPMA PQRTGMQPQM
760 770 780 790 800
TGGPMLPQRT GGMAPQPTGM PGQWGFINTP LSNLPGIEAL GQQMMPNAPS
810 820 830 840 850
GGLNNTFQQK KDIPWAISKE EKRIYDQIFD AWDKERKGTL GGNAVLEIFG
860 870 880 890 900
QSKLTRTELE HIWNLCDHGD KGSLDRDEFA VALHLIYRKL NGNEVPAVLP
910 920 930 940 950
PELIPPSTRN FTESLNQVKN LIKNDTSNRK PFGAENQSKL KKNSFYDNPS
960 970 980 990 1000
ETTEKDATLY RHNDSDASAY VSSARRRDFK EEKIESAPPI INDIDSEIAS
1010 1020 1030 1040 1050
LKKRIHEKSL VVNALEDKKL AATPANDVQN DSLIYRIKSV QDEINRLSTS
1060 1070 1080 1090 1100
NKSPEVASMN VRLEELSTRV SKMLSDINEV DHTIASLSLK LFQAEDTKNS
1110 1120 1130 1140 1150
YDQTSPEATQ ERNRTISSKL AEMEKQKNES KAALEQMKNY VTNIENNIRA
1160 1170 1180 1190 1200
KLLPSAANDD AWLSQNVVDE SVTRVVKELP VPAPAAPQTL NPPSVSTVQQ
1210 1220 1230 1240 1250
SKPIESNTHT PEVKATSESP SASSNLEDRA ARIKAEAQRR MNERLAALGI
1260 1270 1280 1290 1300
KPRQKGTPSP APVNSATSTP VAAPTAQQIQ PGKQASAVSS NVPAVSASIS
1310 1320 1330 1340 1350
TPPAVVPTVQ HPQPTKQIPT AAVKDPSTTS TSFNTAPIPQ QAPLENQFSK
1360 1370 1380 1390 1400
MSLEPPVRPA VPTSPKPQIP DSSNVHAPPP PVQPMNAMPS HNAVNARPSA
1410 1420 1430 1440 1450
PERRDSFGSV SSGSNVSSIE DETSTMPLKA SQPTNPGAPS NHAPQVVPPA
1460 1470 1480 1490 1500
PMHAVAPVQP KAPGMVTNAP APSSAPAPPA PVSQLPPAVP NVPVPSMIPS
1510 1520 1530 1540 1550
VAQQPPSSVA PATAPSSTLP PSQSSFAHVP SPAPPAPQHP SAAALSSAPA
1560 1570 1580 1590 1600
DNSMPHRSSP YAPQEPVQKP QAINNIAPAT NLGTSQSFSP RMGPVNNSGS
1610 1620 1630 1640 1650
PLAMNAAGQP SLAVPAVPSA PSNHFNPFAK MQPPAPSPLQ PSGHDSDNWS
1660 1670 1680 1690 1700
QHGDEEEEDS EDDIRSSKDA AALAAKLFGG MAPAHPVSTP PVRPQSAAPP
1710 1720 1730 1740 1750
QMSAPTPPPP PMSVPPPPSA PPMPAGPPSA PPPPLPASSA PSVPNPGDRS
1760 1770 1780 1790
ALLQQIHTGT RLKKTVTTDK SKPIAGRVLD ASDGNSSAWY GNLS
Length:1,794
Mass (Da):193,279
Last modified:October 1, 1996 - v1
Checksum:i1F042BA5E80E9E27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127P → L in BAA87176 (PubMed:10759889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA94638.1.
AB027872 Genomic DNA. Translation: BAA87176.1.
PIRiT38459.
RefSeqiXP_001713105.1. XM_001713053.2.

Genome annotation databases

EnsemblFungiiSPAC25G10.09c.1; SPAC25G10.09c.1:pep; SPAC25G10.09c.
GeneIDi5802955.
KEGGispo:SPAC25G10.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA94638.1.
AB027872 Genomic DNA. Translation: BAA87176.1.
PIRiT38459.
RefSeqiXP_001713105.1. XM_001713053.2.

3D structure databases

ProteinModelPortaliQ10172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi858093. 6 interactors.
MINTiMINT-4697464.

PTM databases

iPTMnetiQ10172.

Proteomic databases

MaxQBiQ10172.
PRIDEiQ10172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC25G10.09c.1; SPAC25G10.09c.1:pep; SPAC25G10.09c.
GeneIDi5802955.
KEGGispo:SPAC25G10.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.09c.
PomBaseiSPAC25G10.09c. pan1.

Phylogenomic databases

InParanoidiQ10172.
KOiK20047.
OMAiPQRTGMQ.
OrthoDBiEOG092C25IB.
PhylomeDBiQ10172.

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.
R-SPO-416482. G alpha (12/13) signalling events.

Miscellaneous databases

PROiQ10172.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR013182. DUF1720.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR026812. Pan1.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR11216:SF79. PTHR11216:SF79. 5 hits.
PfamiPF08226. DUF1720. 4 hits.
PF12763. EF-hand_4. 2 hits.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00027. EH. 2 hits.
SM00246. WH2. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAN1_SCHPO
AccessioniPrimary (citable) accession number: Q10172
Secondary accession number(s): Q9USC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.