ID   UBLH1_SCHPO             Reviewed;         222 AA.
AC   Q10171;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Probable ubiquitin carboxyl-terminal hydrolase 1;
DE            EC=3.1.2.15;
GN   Name=uch1; ORFNames=SPAC27F1.03c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Ubiquitin-protein hydrolase is involved both in the
CC       processing of ubiquitin precursors and of ubiquitinated proteins.
CC       This enzyme is a thiol protease that recognizes and hydrolyzes a
CC       peptide bond at the C-terminal glycine of ubiquitin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Ubiquitin C-terminal thioester + H(2)O =
CC       ubiquitin + a thiol.
CC   -!- SIMILARITY: Belongs to the peptidase C12 family.
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DR   EMBL; CU329670; CAA93292.1; -; Genomic_DNA.
DR   PIR; T38461; T38461.
DR   RefSeq; NP_594531.1; -.
DR   HSSP; P35127; 1CMX.
DR   GeneID; 2541733; -.
DR   KEGG; spo:SPAC27F1.03c; -.
DR   NMPDR; fig|4896.1.peg.4501; -.
DR   GeneDB_Spombe; SPAC27F1.03c; -.
DR   OMA; Q10171; RRPFARE.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-002628-MON; -.
DR   BRENDA; 3.1.2.15; 653.
DR   ArrayExpress; Q10171; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe.
DR   GO; GO:0043234; C:protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004221; F:ubiquitin thiolesterase activity; IEA:EC.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR001578; Peptidase_C12.
DR   Gene3D; G3DSA:3.40.532.10; Peptidase_C12; 1.
DR   PANTHER; PTHR10589; Peptidase_C12; 1.
DR   Pfam; PF01088; Peptidase_C12; 1.
DR   PRINTS; PR00707; UBCTHYDRLASE.
DR   ProDom; PD350662; Peptidase_C12; 1.
DR   PROSITE; PS00140; UCH_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Protease; Proteasome; Thiol protease;
KW   Ubl conjugation pathway.
FT   CHAIN         1    222       Probable ubiquitin carboxyl-terminal
FT                                hydrolase 1.
FT                                /FTId=PRO_0000211074.
FT   REGION       44     61       Ubiquitin binding 1 (Potential).
FT   REGION      171    179       Ubiquitin binding 2 (Potential).
FT   ACT_SITE     83     83       By similarity.
FT   ACT_SITE    158    158       By similarity.
FT   ACT_SITE    177    177       By similarity.
SQ   SEQUENCE   222 AA;  24913 MW;  218317B99BEC35B0 CRC64;
     MWRPLENTPE VLEPYLQKIG VQDASVFDLF SLEEIPEYIP RPVHALLFVF PSSGTKTIYK
     GSRILPKDSD KVLWYPQTIP NACGTIGLLH AVSNGELRRK VNENDFIKSL IRTAEGSSIE
     ERAKLIEDSK ELEALHAAFA GPPLEVEGSE EDVETDLHFI CFVKGKSKDD NHFYELDGRQ
     EGPVQHSEIE SDLLNAEVLS VIKNYIQSID SPFFSLVAIT TP
//