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Q10171

- UBLH1_SCHPO

UniProt

Q10171 - UBLH1_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 1

Gene

uch1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831NucleophilePROSITE-ProRule annotation
    Active sitei158 – 1581Proton donorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase
    2. ubiquitin thiolesterase activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.A10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
    Gene namesi
    Name:uch1
    ORF Names:SPAC27F1.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC27F1.03c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase
    4. proteasome complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Probable ubiquitin carboxyl-terminal hydrolase 1PRO_0000211074Add
    BLAST

    Proteomic databases

    MaxQBiQ10171.

    Interactioni

    Protein-protein interaction databases

    BioGridi278227. 31 interactions.
    MINTiMINT-4697454.
    STRINGi4896.SPAC27F1.03c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family.Curated

    Phylogenomic databases

    eggNOGiNOG327708.
    HOGENOMiHOG000182400.
    KOiK05609.
    OMAiYVCFVKG.
    OrthoDBiEOG7PGF2F.
    PhylomeDBiQ10171.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.
    PROSITEiPS00140. UCH_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10171-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRPLENTPE VLEPYLQKIG VQDASVFDLF SLEEIPEYIP RPVHALLFVF    50
    PSSGTKTIYK GSRILPKDSD KVLWYPQTIP NACGTIGLLH AVSNGELRRK 100
    VNENDFIKSL IRTAEGSSIE ERAKLIEDSK ELEALHAAFA GPPLEVEGSE 150
    EDVETDLHFI CFVKGKSKDD NHFYELDGRQ EGPVQHSEIE SDLLNAEVLS 200
    VIKNYIQSID SPFFSLVAIT TP 222
    Length:222
    Mass (Da):24,913
    Last modified:October 1, 1996 - v1
    Checksum:i218317B99BEC35B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93292.1.
    PIRiT38461.
    RefSeqiNP_594531.1. NM_001019960.2.

    Genome annotation databases

    EnsemblFungiiSPAC27F1.03c.1; SPAC27F1.03c.1:pep; SPAC27F1.03c.
    GeneIDi2541733.
    KEGGispo:SPAC27F1.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA93292.1 .
    PIRi T38461.
    RefSeqi NP_594531.1. NM_001019960.2.

    3D structure databases

    ProteinModelPortali Q10171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278227. 31 interactions.
    MINTi MINT-4697454.
    STRINGi 4896.SPAC27F1.03c-1.

    Protein family/group databases

    MEROPSi C12.A10.

    Proteomic databases

    MaxQBi Q10171.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC27F1.03c.1 ; SPAC27F1.03c.1:pep ; SPAC27F1.03c .
    GeneIDi 2541733.
    KEGGi spo:SPAC27F1.03c.

    Organism-specific databases

    PomBasei SPAC27F1.03c.

    Phylogenomic databases

    eggNOGi NOG327708.
    HOGENOMi HOG000182400.
    KOi K05609.
    OMAi YVCFVKG.
    OrthoDBi EOG7PGF2F.
    PhylomeDBi Q10171.

    Miscellaneous databases

    NextBioi 20802824.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    PROSITEi PS00140. UCH_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBLH1_SCHPO
    AccessioniPrimary (citable) accession number: Q10171
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3