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Protein

Probable ubiquitin carboxyl-terminal hydrolase 1

Gene

uch1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83NucleophilePROSITE-ProRule annotation1
Active sitei158Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5689603 UCH proteinases
R-SPO-8951664 Neddylation

Protein family/group databases

MEROPSiC12.A10

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
Gene namesi
Name:uch1
ORF Names:SPAC27F1.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27F1.03c
PomBaseiSPAC27F1.03c uch1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110741 – 222Probable ubiquitin carboxyl-terminal hydrolase 1Add BLAST222

Proteomic databases

MaxQBiQ10171
PaxDbiQ10171
PRIDEiQ10171

Interactioni

Protein-protein interaction databases

BioGridi278227, 31 interactors
STRINGi4896.SPAC27F1.03c.1

Structurei

3D structure databases

ProteinModelPortaliQ10171
SMRiQ10171
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.Curated

Phylogenomic databases

HOGENOMiHOG000182400
InParanoidiQ10171
KOiK05609
OMAiVYGMEPE
OrthoDBiEOG092C4ZXA
PhylomeDBiQ10171

Family and domain databases

Gene3Di3.40.532.10, 1 hit
InterProiView protein in InterPro
IPR001578 Peptidase_C12_UCH
IPR036959 Peptidase_C12_UCH_sf
PANTHERiPTHR10589 PTHR10589, 1 hit
PfamiView protein in Pfam
PF01088 Peptidase_C12, 1 hit
PRINTSiPR00707 UBCTHYDRLASE
PROSITEiView protein in PROSITE
PS00140 UCH_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q10171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRPLENTPE VLEPYLQKIG VQDASVFDLF SLEEIPEYIP RPVHALLFVF
60 70 80 90 100
PSSGTKTIYK GSRILPKDSD KVLWYPQTIP NACGTIGLLH AVSNGELRRK
110 120 130 140 150
VNENDFIKSL IRTAEGSSIE ERAKLIEDSK ELEALHAAFA GPPLEVEGSE
160 170 180 190 200
EDVETDLHFI CFVKGKSKDD NHFYELDGRQ EGPVQHSEIE SDLLNAEVLS
210 220
VIKNYIQSID SPFFSLVAIT TP
Length:222
Mass (Da):24,913
Last modified:October 1, 1996 - v1
Checksum:i218317B99BEC35B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93292.1
PIRiT38461
RefSeqiNP_594531.1, NM_001019960.2

Genome annotation databases

EnsemblFungiiSPAC27F1.03c.1; SPAC27F1.03c.1:pep; SPAC27F1.03c
GeneIDi2541733
KEGGispo:SPAC27F1.03c

Similar proteinsi

Entry informationi

Entry nameiUBLH1_SCHPO
AccessioniPrimary (citable) accession number: Q10171
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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