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Q10171

- UBLH1_SCHPO

UniProt

Q10171 - UBLH1_SCHPO

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Protein

Probable ubiquitin carboxyl-terminal hydrolase 1

Gene

uch1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831NucleophilePROSITE-ProRule annotation
Active sitei158 – 1581Proton donorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase
  2. ubiquitin thiolesterase activity Source: PomBase

GO - Biological processi

  1. protein deubiquitination Source: PomBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.12)
Gene namesi
Name:uch1
ORF Names:SPAC27F1.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC27F1.03c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
  4. proteasome complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Probable ubiquitin carboxyl-terminal hydrolase 1PRO_0000211074Add
BLAST

Proteomic databases

MaxQBiQ10171.

Interactioni

Protein-protein interaction databases

BioGridi278227. 31 interactions.
MINTiMINT-4697454.
STRINGi4896.SPAC27F1.03c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.Curated

Phylogenomic databases

eggNOGiNOG327708.
HOGENOMiHOG000182400.
InParanoidiQ10171.
KOiK05609.
OMAiYVCFVKG.
OrthoDBiEOG7PGF2F.
PhylomeDBiQ10171.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiPS00140. UCH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10171-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWRPLENTPE VLEPYLQKIG VQDASVFDLF SLEEIPEYIP RPVHALLFVF
60 70 80 90 100
PSSGTKTIYK GSRILPKDSD KVLWYPQTIP NACGTIGLLH AVSNGELRRK
110 120 130 140 150
VNENDFIKSL IRTAEGSSIE ERAKLIEDSK ELEALHAAFA GPPLEVEGSE
160 170 180 190 200
EDVETDLHFI CFVKGKSKDD NHFYELDGRQ EGPVQHSEIE SDLLNAEVLS
210 220
VIKNYIQSID SPFFSLVAIT TP
Length:222
Mass (Da):24,913
Last modified:October 1, 1996 - v1
Checksum:i218317B99BEC35B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA93292.1.
PIRiT38461.
RefSeqiNP_594531.1. NM_001019960.2.

Genome annotation databases

EnsemblFungiiSPAC27F1.03c.1; SPAC27F1.03c.1:pep; SPAC27F1.03c.
GeneIDi2541733.
KEGGispo:SPAC27F1.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA93292.1 .
PIRi T38461.
RefSeqi NP_594531.1. NM_001019960.2.

3D structure databases

ProteinModelPortali Q10171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278227. 31 interactions.
MINTi MINT-4697454.
STRINGi 4896.SPAC27F1.03c-1.

Protein family/group databases

MEROPSi C12.A10.

Proteomic databases

MaxQBi Q10171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC27F1.03c.1 ; SPAC27F1.03c.1:pep ; SPAC27F1.03c .
GeneIDi 2541733.
KEGGi spo:SPAC27F1.03c.

Organism-specific databases

PomBasei SPAC27F1.03c.

Phylogenomic databases

eggNOGi NOG327708.
HOGENOMi HOG000182400.
InParanoidi Q10171.
KOi K05609.
OMAi YVCFVKG.
OrthoDBi EOG7PGF2F.
PhylomeDBi Q10171.

Miscellaneous databases

NextBioi 20802824.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
PROSITEi PS00140. UCH_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBLH1_SCHPO
AccessioniPrimary (citable) accession number: Q10171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3