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Protein

Protein arginine N-methyltransferase 2

Gene

rmt2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei140 – 1401S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei174 – 1741S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei261 – 2611S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:rmt2By similarity
ORF Names:SPAC26A3.17cImported, SPAC8E11.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.17c.
PomBaseiSPAC26A3.17c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Protein arginine N-methyltransferase 2PRO_0000116476Add
BLAST

Proteomic databases

MaxQBiQ10170.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi279139. 1 interaction.
MINTiMINT-4697441.

Structurei

3D structure databases

ProteinModelPortaliQ10170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 357228RMT2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 1996S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
Regioni215 – 2173S-adenosyl-L-methionine bindingPROSITE-ProRule annotation
Regioni242 – 2432S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation
Contains 1 RMT2 (arginine N-methyltransferase 2-like) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ10170.
KOiK18477.
OMAiFFQGVAC.
OrthoDBiEOG7CG78C.
PhylomeDBiQ10170.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51559. SAM_RMT2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPLVNESV EFQESQESLS LLEASKQLDL KKIQNLVDQG AVTSAIDIES
60 70 80 90 100
GKNALHFIAS YAEKETEVQA IEVTKWILSN GGVWNGIDRA NETPGCIARR
110 120 130 140 150
RNLLRLYETI VDAGVRSELL LSLLERKELT NEQLDTNEKY LQSALSYTQP
160 170 180 190 200
TEDSSSLLDS DANAVMMSWE RKIMHRSAEI IAPTKGRRVL NVGFGLGIID
210 220 230 240 250
TFLQEKEPSL HVIIEPHPDV LKHMRKNGWM DRENVIVYET TWENAINDIA
260 270 280 290 300
SKYVFDGIYY DAFAESYEDL RNFFDSVVGL LDPETDSKFS FFNGLGADNQ
310 320 330 340 350
TFYDVYKKLV PIDLVSFGLQ CTYESMPVSS KDEEWKGAKR RYWDVSKYFL

PIVTFDF
Length:357
Mass (Da):40,709
Last modified:January 11, 2001 - v2
Checksum:i5529B8D3B88D91A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93240.1.
PIRiT38405.
RefSeqiNP_594160.2. NM_001019584.2.

Genome annotation databases

EnsemblFungiiSPAC26A3.17c.1; SPAC26A3.17c.1:pep; SPAC26A3.17c.
GeneIDi2542686.
KEGGispo:SPAC26A3.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93240.1.
PIRiT38405.
RefSeqiNP_594160.2. NM_001019584.2.

3D structure databases

ProteinModelPortaliQ10170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279139. 1 interaction.
MINTiMINT-4697441.

Proteomic databases

MaxQBiQ10170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC26A3.17c.1; SPAC26A3.17c.1:pep; SPAC26A3.17c.
GeneIDi2542686.
KEGGispo:SPAC26A3.17c.

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.17c.
PomBaseiSPAC26A3.17c.

Phylogenomic databases

HOGENOMiHOG000214351.
InParanoidiQ10170.
KOiK18477.
OMAiFFQGVAC.
OrthoDBiEOG7CG78C.
PhylomeDBiQ10170.

Miscellaneous databases

NextBioi20803734.
PROiQ10170.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51559. SAM_RMT2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRMT2_SCHPO
AccessioniPrimary (citable) accession number: Q10170
Secondary accession number(s): Q9Y7I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: May 11, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.