Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein arginine N-methyltransferase 2

Gene

rmt2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei174S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei261S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-71288 Creatine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:rmt2By similarity
ORF Names:SPAC26A3.17cImported, SPAC8E11.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.17c
PomBaseiSPAC26A3.17c rmt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001164761 – 357Protein arginine N-methyltransferase 2Add BLAST357

Proteomic databases

MaxQBiQ10170
PaxDbiQ10170
PRIDEiQ10170

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi279139, 1 interactor
STRINGi4896.SPAC26A3.17c.1

Structurei

3D structure databases

ProteinModelPortaliQ10170
SMRiQ10170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 357RMT2PROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 199S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni215 – 217S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni242 – 243S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351
InParanoidiQ10170
KOiK18477
OMAiAVWNAVD
OrthoDBiEOG092C2OT7
PhylomeDBiQ10170

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017408 Arginine_N-MeTrfase_2
IPR026480 RMT2_dom
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF038148 Arginine_N-mtfrase-2, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51559 SAM_RMT2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPLVNESV EFQESQESLS LLEASKQLDL KKIQNLVDQG AVTSAIDIES
60 70 80 90 100
GKNALHFIAS YAEKETEVQA IEVTKWILSN GGVWNGIDRA NETPGCIARR
110 120 130 140 150
RNLLRLYETI VDAGVRSELL LSLLERKELT NEQLDTNEKY LQSALSYTQP
160 170 180 190 200
TEDSSSLLDS DANAVMMSWE RKIMHRSAEI IAPTKGRRVL NVGFGLGIID
210 220 230 240 250
TFLQEKEPSL HVIIEPHPDV LKHMRKNGWM DRENVIVYET TWENAINDIA
260 270 280 290 300
SKYVFDGIYY DAFAESYEDL RNFFDSVVGL LDPETDSKFS FFNGLGADNQ
310 320 330 340 350
TFYDVYKKLV PIDLVSFGLQ CTYESMPVSS KDEEWKGAKR RYWDVSKYFL

PIVTFDF
Length:357
Mass (Da):40,709
Last modified:January 11, 2001 - v2
Checksum:i5529B8D3B88D91A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93240.1
PIRiT38405
RefSeqiNP_594160.2, NM_001019584.2

Genome annotation databases

EnsemblFungiiSPAC26A3.17c.1; SPAC26A3.17c.1:pep; SPAC26A3.17c
GeneIDi2542686
KEGGispo:SPAC26A3.17c

Similar proteinsi

Entry informationi

Entry nameiRMT2_SCHPO
AccessioniPrimary (citable) accession number: Q10170
Secondary accession number(s): Q9Y7I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health