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Protein

Deubiquitination-protection protein dph1

Gene

dph1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.1 Publication

GO - Molecular functioni

  • polyubiquitin modification-dependent protein binding Source: PomBase

GO - Biological processi

  • negative regulation of protein catabolic process Source: PomBase
  • ubiquitin-dependent ERAD pathway Source: PomBase

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-8856825 Cargo recognition for clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Deubiquitination-protection protein dph1
Gene namesi
Name:dph1
ORF Names:SPAC26A3.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.16
PomBaseiSPAC26A3.16 dph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149011 – 354Deubiquitination-protection protein dph1Add BLAST354

Proteomic databases

MaxQBiQ10169
PaxDbiQ10169
PRIDEiQ10169

PTM databases

iPTMnetiQ10169

Interactioni

GO - Molecular functioni

  • polyubiquitin modification-dependent protein binding Source: PomBase

Protein-protein interaction databases

BioGridi279120, 28 interactors
MINTiQ10169
STRINGi4896.SPAC26A3.16.1

Structurei

3D structure databases

ProteinModelPortaliQ10169
SMRiQ10169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 78Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78
Domaini309 – 353UBAPROSITE-ProRule annotationAdd BLAST45

Phylogenomic databases

HOGENOMiHOG000216678
KOiK04523
OMAiIQQMLQA
OrthoDBiEOG092C5V3D
PhylomeDBiQ10169

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR10677 PTHR10677, 2 hits
PfamiView protein in Pfam
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00727 STI1, 2 hits
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNISLTIKA ANDQKYAVTV DSESSVLALK EAIAPVADIE KERQRLIYAG
60 70 80 90 100
RVLKDEESLK TYKIQDGHSI HLVKTLGQNP AAAATNVSDR TQQVPTNIQA
110 120 130 140 150
GQGANNPLAN LTSARYAGFN IPMPSASMFG PNPENPVPPS TEELANMLSN
160 170 180 190 200
PMVQSSINEM FSNPQMLDMI INSSPHLRNA PPYVRQMMQS PEFRRAMTDP
210 220 230 240 250
DTMRQMAQLH QQMGAAGIDP MSLMGGGLGG AGLGGLGGAG LGGFGGANNA
260 270 280 290 300
TAGIAGAAPV DQTAAANTIQ NLLNNLGGAG FGAGLGDAGL GAGLGGAASP
310 320 330 340 350
PAPAQDTRPP EERYAEQLSQ LNEMGFVDFE RNVQALRRSG GNVQGAIESL

LSDL
Length:354
Mass (Da):36,819
Last modified:October 1, 1996 - v1
Checksum:i1A99B2D97E73A831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93239.1
PIRiT38404
RefSeqiNP_594159.1, NM_001019583.2

Genome annotation databases

EnsemblFungiiSPAC26A3.16.1; SPAC26A3.16.1:pep; SPAC26A3.16
GeneIDi2542667
KEGGispo:SPAC26A3.16

Similar proteinsi

Entry informationi

Entry nameiDSK2_SCHPO
AccessioniPrimary (citable) accession number: Q10169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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