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Protein

Probable Rho-type GTPase-activating protein 2

Gene

rga2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for Rho-type proteins.Curated

GO - Molecular functioni

  • GTPase activator activity Source: PomBase

GO - Biological processi

  • negative regulation of Rho protein signal transduction Source: PomBase
  • positive regulation of GTPase activity Source: PomBase
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.
R-SPO-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Rho-type GTPase-activating protein 2
Gene namesi
Name:rga2
ORF Names:SPAC26A3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.09c.
PomBaseiSPAC26A3.09c. rga2.

Subcellular locationi

GO - Cellular componenti

  • actomyosin contractile ring Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytoplasm Source: PomBase
  • growing cell tip Source: PomBase
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12751275Probable Rho-type GTPase-activating protein 2PRO_0000097312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei388 – 3881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10164.

PTM databases

iPTMnetiQ10164.

Interactioni

Protein-protein interaction databases

BioGridi279135. 62 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ10164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini719 – 836118PHPROSITE-ProRule annotationAdd
BLAST
Domaini1065 – 1275211Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ10164.
KOiK08773.
OrthoDBiEOG7DC2CS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMDVVRTT GFFLRSEPTT CRITTFAYSA EIIYFHAETT FLFEKIMKEG
60 70 80 90 100
NELEKYSKIE LNSEIWEDEE EEDNSGIVSQ NERLMKLVNK QREIIYELHK
110 120 130 140 150
DLEKVKKDNT SLRMRLSKYE STDSFPSSQP SRANSPQSDS YSSPYEKGKL
160 170 180 190 200
FPKISLKSSK DVPTASAHIS SSDHEKSSSV SLSALNNYNK TTDIKARSLD
210 220 230 240 250
RLSDMTRPKL LLNTKRSHRS SEEPGASSPV TSPILKDSQK ERIQALRNKA
260 270 280 290 300
IKTYSVSTES AERIDSIRSD NLSPLSLNTS SFRRPITKPT PFNSDSNISI
310 320 330 340 350
DPKDNNSNKQ DHFAEIEDEL RQQFLDIKVG RANASSPRRK SISIVKPHGI
360 370 380 390 400
SSPKHSTNNL SSKSGKFHSD FRVVSENVLL QARSETNSPI IENKEANNFL
410 420 430 440 450
APTSNVPAYS TPARPTESPP PPPISSSSTT PRPDDKPSLP PRGLSEDNDS
460 470 480 490 500
LSLQKTGSSD TRRSSFSTLK IPDSDICFTR RRSDSNRTWT VIDPHHSQSF
510 520 530 540 550
DNDILAEIPT SKLDNSSQKS PGKLSSKGLL NSFSPISPFS KSKSHNHHPS
560 570 580 590 600
SQVEKSTSNS KGSMLPLDTL YNNKLSFRLD ESLVRYLRFE LMKTSLASLS
610 620 630 640 650
PDFDCIGLQF VVGVSASSHL ASQWKDEVWS FTRSIGECRS FATSFVLDIG
660 670 680 690 700
APPFPTLDWF TNDSSVIQNE LLRRSVDTYF RYIFQTDLKL EQRIKLLEFL
710 720 730 740 750
SSDTLREYLH DVFFLPPEHA QKEGVLLKYI ENSGLVSRYF YLKDNILYFA
760 770 780 790 800
ENRNSPVLGT IHLKDAQVNR YNANLPIFSI IDPPHEFLTG ENYQSAFVIQ
810 820 830 840 850
EKQTETRTGT ATVHVLLARD VEDQKSWLRA ILRQVPGSTS PLNASPFSVL
860 870 880 890 900
SSDFPGSSRY RDQSSPIRFY GKADSRPVSQ EAILSQDISS SPSPVLPPSE
910 920 930 940 950
NVASYADDSL VSNLTMSPKL RDSMEQVPLE NHREFEISDR VSELSFDSST
960 970 980 990 1000
GSVLEIADTR RNQDAPEKHV PVIEIQSSRP SLEKTDQSTP VELLIDSHSQ
1010 1020 1030 1040 1050
NSQNEEKRSR MKFWAFPHHK AENYEQISDT NIPVIETNVM LSPSSTTSAE
1060 1070 1080 1090 1100
PLQKHIVRKS GIFGLPLNEA VNISTQFNDS GLPIVVYRCI EYLESCRAEK
1110 1120 1130 1140 1150
EEGIYRLSGS ASTIKHLKEQ FNEGVDYDLL SSDEEFDVHV IAGLLKLYLR
1160 1170 1180 1190 1200
NLPTNLLDTS MHKLFELLPN VPNDSAALGE LCDVISKLPP ENFALLDSLL
1210 1220 1230 1240 1250
HHLRRIIAFE KVNKMNIRNV CIVFSPTLNI PSDIFMMLIL NYDHIFTDIS
1260 1270
RQTNGAQNES DSDVSDDNGE DNEFF
Length:1,275
Mass (Da):143,588
Last modified:October 1, 1996 - v1
Checksum:i136DA1A26B4A1BBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93232.1.
AB027912 Genomic DNA. Translation: BAA87216.1.
PIRiT38397.
RefSeqiNP_594152.1. NM_001019576.2.

Genome annotation databases

EnsemblFungiiSPAC26A3.09c.1; SPAC26A3.09c.1:pep; SPAC26A3.09c.
GeneIDi2542682.
KEGGispo:SPAC26A3.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93232.1.
AB027912 Genomic DNA. Translation: BAA87216.1.
PIRiT38397.
RefSeqiNP_594152.1. NM_001019576.2.

3D structure databases

ProteinModelPortaliQ10164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279135. 62 interactions.

PTM databases

iPTMnetiQ10164.

Proteomic databases

MaxQBiQ10164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC26A3.09c.1; SPAC26A3.09c.1:pep; SPAC26A3.09c.
GeneIDi2542682.
KEGGispo:SPAC26A3.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.09c.
PomBaseiSPAC26A3.09c. rga2.

Phylogenomic databases

InParanoidiQ10164.
KOiK08773.
OrthoDBiEOG7DC2CS.

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.
R-SPO-416482. G alpha (12/13) signalling events.

Miscellaneous databases

PROiQ10164.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 69-301, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  3. "Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe."
    Nakano K., Mutoh T., Mabuchi I.
    Genes Cells 6:1031-1042(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiRGA2_SCHPO
AccessioniPrimary (citable) accession number: Q10164
Secondary accession number(s): Q9USA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.