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Protein

Inositol phosphorylceramide synthase catalytic subunit aur1

Gene

aur1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.By similarity

Enzyme regulationi

Inhibited by aureobasidin A (AbA).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphorylceramide synthase catalytic subunit aur1 (EC:2.-.-.-)
Short name:
IPC synthase catalytic subunit aur1
Alternative name(s):
Aureobasidin A resistance protein homolog
Phosphatidylinositol:ceramide phosphoinositol transferase
Gene namesi
Name:aur1
ORF Names:SPAC3H8.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H8.06.
PomBaseiSPAC3H8.06. aur1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicBy similarityAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 87CytoplasmicBy similarity2
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 159LumenalBy similarityAdd BLAST51
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 183CytoplasmicBy similarity3
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 245LumenalBy similarityAdd BLAST41
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 274CytoplasmicBy similarity8
Transmembranei275 – 292HelicalSequence analysisAdd BLAST18
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 422CytoplasmicBy similarityAdd BLAST109

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240G → C in aur1-1; AbA resistant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647651 – 422Inositol phosphorylceramide synthase catalytic subunit aur1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Modified residuei353Phosphoserine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ10142.

PTM databases

iPTMnetiQ10142.

Interactioni

Subunit structurei

Component of the inositol phosphorylceramide synthase complex composed of at least aur1 and kei1.By similarity

Protein-protein interaction databases

MINTiMINT-4697214.

Structurei

3D structure databases

ProteinModelPortaliQ10142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AUR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000196614.
InParanoidiQ10142.
OMAiLANTDHE.
OrthoDBiEOG092C20GL.
PhylomeDBiQ10142.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR026841. Aur1/Ipt1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF14378. PAP2_3. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALSTLKKR LAACNRASQY KLETSLNPMP TFRLLRNTKW SWTHLQYVFL
60 70 80 90 100
AGNLIFACIV IESPGFWGKF GIACLLAIAL TVPLTRQIFF PAIVIITWAI
110 120 130 140 150
LFYSCRFIPE RWRPPIWVRV LPTLENILYG SNLSSLLSKT THSILDILAW
160 170 180 190 200
VPYGVMHYSA PFIISFILFI FAPPGTLPVW ARTFGYMNLF GVLIQMAFPC
210 220 230 240 250
SPPWYENMYG LEPATYAVRG SPGGLARIDA LFGTSIYTDG FSNSPVVFGA
260 270 280 290 300
FPSLHAGWAM LEALFLSHVF PRYRFCFYGY VLWLCWCTMY LTHHYFVDLV
310 320 330 340 350
GGMCLAIICF VFAQKLRLPQ LQTGKILRWE YEFVIHGHGL SEKTSNSLAR
360 370 380 390 400
TGSPYLLGRD SFTQNPNAVA FMSGLNNMEL ANTDHEWSVG SSSPEPLPSP
410 420
AADLIDRPAS TTSSIFDASH LP
Length:422
Mass (Da):47,444
Last modified:October 1, 1996 - v1
Checksum:iC24EC4E3423E442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000821 Genomic DNA. Translation: BAA19190.1.
CU329670 Genomic DNA. Translation: CAA93163.1.
PIRiT38764.
RefSeqiNP_592999.1. NM_001018398.2.

Genome annotation databases

EnsemblFungiiSPAC3H8.06.1; SPAC3H8.06.1:pep; SPAC3H8.06.
GeneIDi2543632.
KEGGispo:SPAC3H8.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000821 Genomic DNA. Translation: BAA19190.1.
CU329670 Genomic DNA. Translation: CAA93163.1.
PIRiT38764.
RefSeqiNP_592999.1. NM_001018398.2.

3D structure databases

ProteinModelPortaliQ10142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4697214.

PTM databases

iPTMnetiQ10142.

Proteomic databases

PRIDEiQ10142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3H8.06.1; SPAC3H8.06.1:pep; SPAC3H8.06.
GeneIDi2543632.
KEGGispo:SPAC3H8.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC3H8.06.
PomBaseiSPAC3H8.06. aur1.

Phylogenomic databases

HOGENOMiHOG000196614.
InParanoidiQ10142.
OMAiLANTDHE.
OrthoDBiEOG092C20GL.
PhylomeDBiQ10142.

Miscellaneous databases

PROiQ10142.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR026841. Aur1/Ipt1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF14378. PAP2_3. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAUR1_SCHPO
AccessioniPrimary (citable) accession number: Q10142
Secondary accession number(s): P79014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.