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Protein

Inositol phosphorylceramide synthase catalytic subunit aur1

Gene

aur1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.By similarity

Enzyme regulationi

Inhibited by aureobasidin A (AbA).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphorylceramide synthase catalytic subunit aur1 (EC:2.-.-.-)
Short name:
IPC synthase catalytic subunit aur1
Alternative name(s):
Aureobasidin A resistance protein homolog
Phosphatidylinositol:ceramide phosphoinositol transferase
Gene namesi
Name:aur1
ORF Names:SPAC3H8.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H8.06.
PomBaseiSPAC3H8.06. aur1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicBy similarityAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8517HelicalSequence analysisAdd
BLAST
Topological domaini86 – 872CytoplasmicBy similarity
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 15951LumenalBy similarityAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 1833CytoplasmicBy similarity
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 24541LumenalBy similarityAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 2748CytoplasmicBy similarity
Transmembranei275 – 29218HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Topological domaini314 – 422109CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi240 – 2401G → C in aur1-1; AbA resistant. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Inositol phosphorylceramide synthase catalytic subunit aur1PRO_0000064765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Modified residuei353 – 3531Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

PTM databases

iPTMnetiQ10142.

Interactioni

Subunit structurei

Component of the inositol phosphorylceramide synthase complex composed of at least aur1 and kei1.By similarity

Protein-protein interaction databases

MINTiMINT-4697214.

Structurei

3D structure databases

ProteinModelPortaliQ10142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AUR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000196614.
InParanoidiQ10142.
OMAiAREHEIN.
OrthoDBiEOG7V76FR.
PhylomeDBiQ10142.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR026841. Aur1/Ipt1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF14378. PAP2_3. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALSTLKKR LAACNRASQY KLETSLNPMP TFRLLRNTKW SWTHLQYVFL
60 70 80 90 100
AGNLIFACIV IESPGFWGKF GIACLLAIAL TVPLTRQIFF PAIVIITWAI
110 120 130 140 150
LFYSCRFIPE RWRPPIWVRV LPTLENILYG SNLSSLLSKT THSILDILAW
160 170 180 190 200
VPYGVMHYSA PFIISFILFI FAPPGTLPVW ARTFGYMNLF GVLIQMAFPC
210 220 230 240 250
SPPWYENMYG LEPATYAVRG SPGGLARIDA LFGTSIYTDG FSNSPVVFGA
260 270 280 290 300
FPSLHAGWAM LEALFLSHVF PRYRFCFYGY VLWLCWCTMY LTHHYFVDLV
310 320 330 340 350
GGMCLAIICF VFAQKLRLPQ LQTGKILRWE YEFVIHGHGL SEKTSNSLAR
360 370 380 390 400
TGSPYLLGRD SFTQNPNAVA FMSGLNNMEL ANTDHEWSVG SSSPEPLPSP
410 420
AADLIDRPAS TTSSIFDASH LP
Length:422
Mass (Da):47,444
Last modified:October 1, 1996 - v1
Checksum:iC24EC4E3423E442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000821 Genomic DNA. Translation: BAA19190.1.
CU329670 Genomic DNA. Translation: CAA93163.1.
PIRiT38764.
RefSeqiNP_592999.1. NM_001018398.2.

Genome annotation databases

EnsemblFungiiSPAC3H8.06.1; SPAC3H8.06.1:pep; SPAC3H8.06.
GeneIDi2543632.
KEGGispo:SPAC3H8.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000821 Genomic DNA. Translation: BAA19190.1.
CU329670 Genomic DNA. Translation: CAA93163.1.
PIRiT38764.
RefSeqiNP_592999.1. NM_001018398.2.

3D structure databases

ProteinModelPortaliQ10142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4697214.

PTM databases

iPTMnetiQ10142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3H8.06.1; SPAC3H8.06.1:pep; SPAC3H8.06.
GeneIDi2543632.
KEGGispo:SPAC3H8.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC3H8.06.
PomBaseiSPAC3H8.06. aur1.

Phylogenomic databases

HOGENOMiHOG000196614.
InParanoidiQ10142.
OMAiAREHEIN.
OrthoDBiEOG7V76FR.
PhylomeDBiQ10142.

Miscellaneous databases

PROiQ10142.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR026841. Aur1/Ipt1.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF14378. PAP2_3. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the aureobasidin A-resistant gene, aur1R, on Schizosaccharomyces pombe: roles of Aur1p+ in cell morphogenesis."
    Hashida-Okado T., Yasumoto R., Endo M., Takesako K., Kato I.
    Curr. Genet. 33:38-45(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF GLY-240.
    Strain: JY745.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAUR1_SCHPO
AccessioniPrimary (citable) accession number: Q10142
Secondary accession number(s): P79014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.