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Protein

Inositol phosphorylceramide synthase catalytic subunit aur1

Gene

aur1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.By similarity

Enzyme regulationi

Inhibited by aureobasidin A (AbA).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol phosphorylceramide synthase catalytic subunit aur1 (EC:2.-.-.-)
Short name:
IPC synthase catalytic subunit aur1
Alternative name(s):
Aureobasidin A resistance protein homolog
Phosphatidylinositol:ceramide phosphoinositol transferase
Gene namesi
Name:aur1
ORF Names:SPAC3H8.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H8.06
PomBaseiSPAC3H8.06 aur1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicBy similarityAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 87CytoplasmicBy similarity2
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 159LumenalBy similarityAdd BLAST51
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 183CytoplasmicBy similarity3
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 245LumenalBy similarityAdd BLAST41
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 274CytoplasmicBy similarity8
Transmembranei275 – 292HelicalSequence analysisAdd BLAST18
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 422CytoplasmicBy similarityAdd BLAST109

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240G → C in aur1-1; AbA resistant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647651 – 422Inositol phosphorylceramide synthase catalytic subunit aur1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei353Phosphoserine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ10142
PRIDEiQ10142

PTM databases

iPTMnetiQ10142

Interactioni

Subunit structurei

Component of the inositol phosphorylceramide synthase complex composed of at least aur1 and kei1.By similarity

Protein-protein interaction databases

STRINGi4896.SPAC3H8.06.1

Structurei

3D structure databases

ProteinModelPortaliQ10142
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AUR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000196614
InParanoidiQ10142
OMAiDYMKAFP
OrthoDBiEOG092C20GL
PhylomeDBiQ10142

Family and domain databases

InterProiView protein in InterPro
IPR026841 Aur1/Ipt1
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF14378 PAP2_3, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q10142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALSTLKKR LAACNRASQY KLETSLNPMP TFRLLRNTKW SWTHLQYVFL
60 70 80 90 100
AGNLIFACIV IESPGFWGKF GIACLLAIAL TVPLTRQIFF PAIVIITWAI
110 120 130 140 150
LFYSCRFIPE RWRPPIWVRV LPTLENILYG SNLSSLLSKT THSILDILAW
160 170 180 190 200
VPYGVMHYSA PFIISFILFI FAPPGTLPVW ARTFGYMNLF GVLIQMAFPC
210 220 230 240 250
SPPWYENMYG LEPATYAVRG SPGGLARIDA LFGTSIYTDG FSNSPVVFGA
260 270 280 290 300
FPSLHAGWAM LEALFLSHVF PRYRFCFYGY VLWLCWCTMY LTHHYFVDLV
310 320 330 340 350
GGMCLAIICF VFAQKLRLPQ LQTGKILRWE YEFVIHGHGL SEKTSNSLAR
360 370 380 390 400
TGSPYLLGRD SFTQNPNAVA FMSGLNNMEL ANTDHEWSVG SSSPEPLPSP
410 420
AADLIDRPAS TTSSIFDASH LP
Length:422
Mass (Da):47,444
Last modified:October 1, 1996 - v1
Checksum:iC24EC4E3423E442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000821 Genomic DNA Translation: BAA19190.1
CU329670 Genomic DNA Translation: CAA93163.1
PIRiT38764
RefSeqiNP_592999.1, NM_001018398.2

Genome annotation databases

EnsemblFungiiSPAC3H8.06.1; SPAC3H8.06.1:pep; SPAC3H8.06
GeneIDi2543632
KEGGispo:SPAC3H8.06

Similar proteinsi

Entry informationi

Entry nameiAUR1_SCHPO
AccessioniPrimary (citable) accession number: Q10142
Secondary accession number(s): P79014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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