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Protein

GTP-binding protein rho2

Gene

rho2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • regulation of alpha-glucan biosynthetic process Source: PomBase
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho2
Gene namesi
Name:rho2
ORF Names:SPAC16.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16.01.
PomBaseiSPAC16.01. rho2.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchor 1 Publication

  • Note: Found at the growing tips of interphase cells and at the septum prior to cytokinesis.

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
  • site of polarized growth Source: PomBase

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989411 – 197GTP-binding protein rho2Add BLAST197
PropeptideiPRO_0000281271198 – 200Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197Cysteine methyl esterBy similarity1
Lipidationi197S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ10133.
PRIDEiQ10133.

PTM databases

SwissPalmiQ10133.

Interactioni

Subunit structurei

Interacts with pck2.1 Publication

Protein-protein interaction databases

BioGridi279222. 38 interactors.
MINTiMINT-4697093.

Structurei

3D structure databases

ProteinModelPortaliQ10133.
SMRiQ10133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiQ10133.
KOiK07975.
OMAiQNVIRRK.
OrthoDBiEOG092C4TDG.
PhylomeDBiQ10133.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51420. RHO. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQSQPIRRK LVVVGDGACG KTSLLSVFTL GYFPTEYVPT VFENYVSDCR
60 70 80 90 100
VDGKSVQLAL WDTAGQEEYE RLRPMSYAKA HIILVGFAID SPDSLENVST
110 120 130 140 150
KWIEEINTLC PNVPFILVGM KADLRSDPVA IEEMRRRNQN FVKSQQAELV
160 170 180 190 200
AQRIGARKYM ECSSLTGDGV DDVFEAATRA ALTVRDSEND KSSTKCCIIS
Length:200
Mass (Da):22,253
Last modified:February 1, 1996 - v1
Checksum:i9200015082FC5EA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38181 mRNA. Translation: BAA07378.1.
CU329670 Genomic DNA. Translation: CAB57399.1.
PIRiJC4045.
RefSeqiNP_594569.1. NM_001019998.3.

Genome annotation databases

EnsemblFungiiSPAC16.01.1; SPAC16.01.1:pep; SPAC16.01.
GeneIDi2542773.
KEGGispo:SPAC16.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38181 mRNA. Translation: BAA07378.1.
CU329670 Genomic DNA. Translation: CAB57399.1.
PIRiJC4045.
RefSeqiNP_594569.1. NM_001019998.3.

3D structure databases

ProteinModelPortaliQ10133.
SMRiQ10133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279222. 38 interactors.
MINTiMINT-4697093.

PTM databases

SwissPalmiQ10133.

Proteomic databases

MaxQBiQ10133.
PRIDEiQ10133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16.01.1; SPAC16.01.1:pep; SPAC16.01.
GeneIDi2542773.
KEGGispo:SPAC16.01.

Organism-specific databases

EuPathDBiFungiDB:SPAC16.01.
PomBaseiSPAC16.01. rho2.

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiQ10133.
KOiK07975.
OMAiQNVIRRK.
OrthoDBiEOG092C4TDG.
PhylomeDBiQ10133.

Miscellaneous databases

PROiPR:Q10133.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51420. RHO. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHO2_SCHPO
AccessioniPrimary (citable) accession number: Q10133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 12, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.