Reviewed,
UniProtKB/Swiss-Prot Q10132 (IDI1_SCHPO)
Last modified
June 16, 2009.
Version 66.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Isopentenyl-diphosphate Delta-isomerase EC=5.3.3.2 Alternative name(s): Isopentenyl pyrophosphate isomerase Short name=IPP isomerase | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 227 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). |
| Catalytic activity | Isopentenyl diphosphate = dimethylallyl diphosphate. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the IPP isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carotenoid biosynthesis Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cholesterol biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleusInferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | hydrolase activity Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 227 | 227 | Isopentenyl-diphosphate Delta-isomerase | PRO_0000205230 | |||||
Sites | |||||||||
| Active site | 87 | 1 | By similarity | ||||||
| Active site | 152 | 1 | By similarity | ||||||
| Metal binding | 41 | 1 | Magnesium By similarity | ||||||
| Metal binding | 52 | 1 | Magnesium By similarity | ||||||
| Metal binding | 150 | 1 | Magnesium By similarity | ||||||
| Metal binding | 152 | 1 | Magnesium By similarity | ||||||
| Binding site | 37 | 1 | Substrate By similarity | ||||||
| Binding site | 71 | 1 | Substrate By similarity | ||||||
| Binding site | 75 | 1 | Substrate By similarity | ||||||
| Binding site | 88 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of Schizosaccharomyces pombe isopentenyl diphosphate isomerase cDNA clones by complementation and synthesis of the enzyme in Escherichia coli." Hahn F.M., Poulter C.D. J. Biol. Chem. 270:11298-11303(1995) [PubMed: 7744766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| U21154 mRNA. Translation: AAA80596.1. CU329671 Genomic DNA. Translation: CAB53731.1. | |
| PIR | A56442. |
| RefSeq | NP_595164.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2540174. |
| KEGG | spo:SPBC106.15. |
| NMPDR | fig|4896.1.peg.1030. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC106.15. |
Phylogenomic databases | |
| OMA | Q10132. NYELGIP. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003261-MON. |
| BRENDA | 5.3.3.2. 653. |
Gene expression databases | |
| ArrayExpress | Q10132. |
Family and domain databases | |
| InterPro | IPR011876. IsopentenylPP_isomerase_typ1. IPR000086. NUDIX_hydrolase_core. [Graphical view] |
| Gene3D | G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit. |
| PANTHER | PTHR10885. IPP_isom_1. 1 hit. |
| Pfam | PF00293. NUDIX. 1 hit. [Graphical view] |
| PIRSF | PIRSF018427. Isopntndiph_ism. 1 hit. |
| ProDom | PD004109. IPP_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR02150. IPP_isom_1. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | IDI1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q10132 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |
