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Protein

Chromo domain-containing protein 1

Gene

chp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.4 Publications

GO - Molecular functioni

  • DNA binding Source: PomBase
  • methylated histone binding Source: PomBase
  • nucleotide binding Source: InterPro
  • single-stranded RNA binding Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cellular protein localization Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing by small RNA Source: PomBase
  • chromosome segregation Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • pericentric heterochromatin assembly Source: PomBase
  • protein localization to chromosome, centromeric region Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Chromosome partition, RNA-mediated gene silencing

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromo domain-containing protein 1
Gene namesi
Name:chp1
ORF Names:SPAC18G6.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC18G6.02c.
PomBaseiSPAC18G6.02c. chp1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: PomBase
  • cytoplasm Source: UniProtKB-KW
  • mating-type region heterochromatin Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nuclear subtelomeric heterochromatin Source: PomBase
  • nucleus Source: PomBase
  • RITS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802381 – 960Chromo domain-containing protein 1Add BLAST960

Proteomic databases

MaxQBiQ10103.
PRIDEiQ10103.

Interactioni

Subunit structurei

Ago1, chp1 and tas3 interact to form the core of the RNA-induced transcriptional silencing (RITS) complex. The RITS complex interacts with the RDRC complex via interaction between ago1 and hrr1. Clr4 has a role in mediating this interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tas3O946873EBI-421832,EBI-423002

GO - Molecular functioni

  • methylated histone binding Source: PomBase

Protein-protein interaction databases

BioGridi278711. 113 interactors.
DIPiDIP-29301N.
IntActiQ10103. 3 interactors.
MINTiMINT-4696926.

Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi18 – 20Combined sources3
Beta strandi21 – 32Combined sources12
Beta strandi34 – 36Combined sources3
Beta strandi38 – 44Combined sources7
Helixi49 – 51Combined sources3
Beta strandi53 – 56Combined sources4
Helixi57 – 60Combined sources4
Turni61 – 63Combined sources3
Helixi64 – 72Combined sources9
Beta strandi519 – 526Combined sources8
Turni527 – 530Combined sources4
Beta strandi531 – 539Combined sources9
Helixi541 – 544Combined sources4
Helixi550 – 558Combined sources9
Beta strandi561 – 564Combined sources4
Beta strandi566 – 569Combined sources4
Helixi570 – 576Combined sources7
Beta strandi582 – 587Combined sources6
Beta strandi589 – 595Combined sources7
Helixi596 – 606Combined sources11
Beta strandi608 – 613Combined sources6
Beta strandi618 – 623Combined sources6
Helixi627 – 632Combined sources6
Beta strandi641 – 648Combined sources8
Helixi653 – 660Combined sources8
Helixi675 – 682Combined sources8
Turni687 – 691Combined sources5
Helixi692 – 694Combined sources3
Beta strandi696 – 701Combined sources6
Helixi707 – 718Combined sources12
Beta strandi723 – 727Combined sources5
Helixi731 – 734Combined sources4
Beta strandi736 – 744Combined sources9
Helixi745 – 747Combined sources3
Turni748 – 750Combined sources3
Helixi751 – 753Combined sources3
Helixi757 – 762Combined sources6
Beta strandi766 – 771Combined sources6
Beta strandi804 – 808Combined sources5
Beta strandi812 – 816Combined sources5
Helixi818 – 823Combined sources6
Helixi827 – 837Combined sources11
Turni838 – 841Combined sources4
Beta strandi842 – 846Combined sources5
Helixi850 – 861Combined sources12
Helixi867 – 882Combined sources16
Beta strandi889 – 891Combined sources3
Helixi894 – 896Combined sources3
Helixi903 – 918Combined sources16
Turni919 – 921Combined sources3
Beta strandi923 – 928Combined sources6
Helixi932 – 934Combined sources3
Beta strandi941 – 944Combined sources4
Helixi946 – 952Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RSNNMR-A1-75[»]
3G7LX-ray2.20A15-75[»]
3TIXX-ray2.90B/D504-960[»]
ProteinModelPortaliQ10103.
SMRiQ10103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10103.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 74ChromoPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 145Poly-Glu4

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ10103.
OrthoDBiEOG092C3CYC.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVKPLPDI DSNEGETDAD VYEVEDILAD RVNKNGINEY YIKWAGYDWY
60 70 80 90 100
DNTWEPEQNL FGAEKVLKKW KKRKKLIAKG LLEPFDAEDN EAKKMKREKE
110 120 130 140 150
ILRQQRQKRK SELTQLSQKV KEKFKKMRKK PARRIVTIAN DEEEEDDQTM
160 170 180 190 200
DEDAFERKSM QGELKERNLT DKTSTLSTSF GETSPDVNPF YLSEWPTVTD
210 220 230 240 250
SILLSKSLSS DAIPLKNGEI KSTMLMPSDS DNSVPGIQNS NNLENTGAFV
260 270 280 290 300
ENANSPQSNT PLSTFRHSSP LSLSPVITSD NDVANSLFFS NSTPLPSSLK
310 320 330 340 350
IKKEAPKLET HTILVSDNSG SLTKQDILSY FAFIKGNIEV FFLKSPKKDK
360 370 380 390 400
VCNMAYIQFD SIEQAKLAYD KGHPSWHVTL VKGKISTDME ECKVSKSILK
410 420 430 440 450
TTPSKKANAR SVSFTQTTTD TLSESEKFAS NVDLDENFDF NVNVTNEDAK
460 470 480 490 500
QLKKSVIGSS WTTVNNDWNS VSKSDQTFEN DGASKVVPAG NITLNSDNSL
510 520 530 540 550
HHSISESEDL SSASTLSDYF RFVLRVGKSL YYAGELSFDI SKLKAETEHQ
560 570 580 590 600
QLLRSLVSCK QVDVLRFVTS QYLEVFGTCL TKVLSGSLCI RSDVDMTHFK
610 620 630 640 650
NILNRGNGAG IVLGSNYTLL LFTEDNNALM NLYDCQGQSN SPFWMVIFEP
660 670 680 690 700
LESILVEWSA KNLRPKKPYH KSQSYLSYLL QLGHIDLHKI GAFQATQILI
710 720 730 740 750
VSKQPSPEAE ELEDTFREAA IPTFRGLEIP ESLFLSQNVF VFLNVSLEDD
760 770 780 790 800
FDQLQFLTLA KRKSCKFFLF GLSLPLKSPN DSHVGTDFKK NNEPLDKLTY
810 820 830 840 850
SQYLRPMFPK GGVVSVTLSA LIKTPRLLEL ISPFLEIKKD SWILILPPSI
860 870 880 890 900
VDMVKSYFVT NNPDKSLLEI QNLLNTLQRY LTNPALKNVT LYQDWDIVID
910 920 930 940 950
DSADVSLAST LQLYQKKNYD KYRRFVLIHE LKNELTPVNG LDIVDYDEFK
960
ETFMRAIGLK
Length:960
Mass (Da):108,726
Last modified:February 1, 1996 - v1
Checksum:iE92C16BBD0D5957C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92382.1.
PIRiT37916.
RefSeqiNP_593666.1. NM_001019098.2.

Genome annotation databases

EnsemblFungiiSPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c.
GeneIDi2542239.
KEGGispo:SPAC18G6.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92382.1.
PIRiT37916.
RefSeqiNP_593666.1. NM_001019098.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RSNNMR-A1-75[»]
3G7LX-ray2.20A15-75[»]
3TIXX-ray2.90B/D504-960[»]
ProteinModelPortaliQ10103.
SMRiQ10103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278711. 113 interactors.
DIPiDIP-29301N.
IntActiQ10103. 3 interactors.
MINTiMINT-4696926.

Proteomic databases

MaxQBiQ10103.
PRIDEiQ10103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c.
GeneIDi2542239.
KEGGispo:SPAC18G6.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC18G6.02c.
PomBaseiSPAC18G6.02c. chp1.

Phylogenomic databases

InParanoidiQ10103.
OrthoDBiEOG092C3CYC.

Miscellaneous databases

EvolutionaryTraceiQ10103.
PROiQ10103.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHP1_SCHPO
AccessioniPrimary (citable) accession number: Q10103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.