Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromo domain-containing protein 1

Gene

chp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.4 Publications

GO - Molecular functioni

  • DNA binding Source: PomBase
  • methylated histone binding Source: PomBase
  • nucleosomal histone binding Source: PomBase
  • nucleotide binding Source: InterPro
  • single-stranded RNA binding Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cellular protein localization Source: PomBase
  • chromatin silencing at centromere outer repeat region Source: PomBase
  • chromatin silencing by small RNA Source: PomBase
  • chromosome segregation Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • pericentric heterochromatin assembly Source: PomBase
  • protein localization to chromosome, centromeric region Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Chromosome partition, RNA-mediated gene silencing

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromo domain-containing protein 1
Gene namesi
Name:chp1
ORF Names:SPAC18G6.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC18G6.02c.
PomBaseiSPAC18G6.02c. chp1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric outer repeat region Source: PomBase
  • cytoplasm Source: UniProtKB-KW
  • mating-type region heterochromatin Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nuclear subtelomeric heterochromatin Source: PomBase
  • nucleus Source: PomBase
  • RITS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Chromo domain-containing protein 1PRO_0000080238Add
BLAST

Proteomic databases

MaxQBiQ10103.

Interactioni

Subunit structurei

Ago1, chp1 and tas3 interact to form the core of the RNA-induced transcriptional silencing (RITS) complex. The RITS complex interacts with the RDRC complex via interaction between ago1 and hrr1. Clr4 has a role in mediating this interaction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tas3O946873EBI-421832,EBI-423002

GO - Molecular functioni

  • methylated histone binding Source: PomBase
  • nucleosomal histone binding Source: PomBase

Protein-protein interaction databases

BioGridi278711. 113 interactions.
DIPiDIP-29301N.
IntActiQ10103. 3 interactions.
MINTiMINT-4696926.

Structurei

Secondary structure

1
960
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi18 – 203Combined sources
Beta strandi21 – 3212Combined sources
Beta strandi34 – 363Combined sources
Beta strandi38 – 447Combined sources
Helixi49 – 513Combined sources
Beta strandi53 – 564Combined sources
Helixi57 – 604Combined sources
Turni61 – 633Combined sources
Helixi64 – 729Combined sources
Beta strandi519 – 5268Combined sources
Turni527 – 5304Combined sources
Beta strandi531 – 5399Combined sources
Helixi541 – 5444Combined sources
Helixi550 – 5589Combined sources
Beta strandi561 – 5644Combined sources
Beta strandi566 – 5694Combined sources
Helixi570 – 5767Combined sources
Beta strandi582 – 5876Combined sources
Beta strandi589 – 5957Combined sources
Helixi596 – 60611Combined sources
Beta strandi608 – 6136Combined sources
Beta strandi618 – 6236Combined sources
Helixi627 – 6326Combined sources
Beta strandi641 – 6488Combined sources
Helixi653 – 6608Combined sources
Helixi675 – 6828Combined sources
Turni687 – 6915Combined sources
Helixi692 – 6943Combined sources
Beta strandi696 – 7016Combined sources
Helixi707 – 71812Combined sources
Beta strandi723 – 7275Combined sources
Helixi731 – 7344Combined sources
Beta strandi736 – 7449Combined sources
Helixi745 – 7473Combined sources
Turni748 – 7503Combined sources
Helixi751 – 7533Combined sources
Helixi757 – 7626Combined sources
Beta strandi766 – 7716Combined sources
Beta strandi804 – 8085Combined sources
Beta strandi812 – 8165Combined sources
Helixi818 – 8236Combined sources
Helixi827 – 83711Combined sources
Turni838 – 8414Combined sources
Beta strandi842 – 8465Combined sources
Helixi850 – 86112Combined sources
Helixi867 – 88216Combined sources
Beta strandi889 – 8913Combined sources
Helixi894 – 8963Combined sources
Helixi903 – 91816Combined sources
Turni919 – 9213Combined sources
Beta strandi923 – 9286Combined sources
Helixi932 – 9343Combined sources
Beta strandi941 – 9444Combined sources
Helixi946 – 9527Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RSNNMR-A1-75[»]
3G7LX-ray2.20A15-75[»]
3TIXX-ray2.90B/D504-960[»]
ProteinModelPortaliQ10103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10103.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 7453ChromoPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 1454Poly-Glu

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ10103.
OrthoDBiEOG092C3CYC.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVKPLPDI DSNEGETDAD VYEVEDILAD RVNKNGINEY YIKWAGYDWY
60 70 80 90 100
DNTWEPEQNL FGAEKVLKKW KKRKKLIAKG LLEPFDAEDN EAKKMKREKE
110 120 130 140 150
ILRQQRQKRK SELTQLSQKV KEKFKKMRKK PARRIVTIAN DEEEEDDQTM
160 170 180 190 200
DEDAFERKSM QGELKERNLT DKTSTLSTSF GETSPDVNPF YLSEWPTVTD
210 220 230 240 250
SILLSKSLSS DAIPLKNGEI KSTMLMPSDS DNSVPGIQNS NNLENTGAFV
260 270 280 290 300
ENANSPQSNT PLSTFRHSSP LSLSPVITSD NDVANSLFFS NSTPLPSSLK
310 320 330 340 350
IKKEAPKLET HTILVSDNSG SLTKQDILSY FAFIKGNIEV FFLKSPKKDK
360 370 380 390 400
VCNMAYIQFD SIEQAKLAYD KGHPSWHVTL VKGKISTDME ECKVSKSILK
410 420 430 440 450
TTPSKKANAR SVSFTQTTTD TLSESEKFAS NVDLDENFDF NVNVTNEDAK
460 470 480 490 500
QLKKSVIGSS WTTVNNDWNS VSKSDQTFEN DGASKVVPAG NITLNSDNSL
510 520 530 540 550
HHSISESEDL SSASTLSDYF RFVLRVGKSL YYAGELSFDI SKLKAETEHQ
560 570 580 590 600
QLLRSLVSCK QVDVLRFVTS QYLEVFGTCL TKVLSGSLCI RSDVDMTHFK
610 620 630 640 650
NILNRGNGAG IVLGSNYTLL LFTEDNNALM NLYDCQGQSN SPFWMVIFEP
660 670 680 690 700
LESILVEWSA KNLRPKKPYH KSQSYLSYLL QLGHIDLHKI GAFQATQILI
710 720 730 740 750
VSKQPSPEAE ELEDTFREAA IPTFRGLEIP ESLFLSQNVF VFLNVSLEDD
760 770 780 790 800
FDQLQFLTLA KRKSCKFFLF GLSLPLKSPN DSHVGTDFKK NNEPLDKLTY
810 820 830 840 850
SQYLRPMFPK GGVVSVTLSA LIKTPRLLEL ISPFLEIKKD SWILILPPSI
860 870 880 890 900
VDMVKSYFVT NNPDKSLLEI QNLLNTLQRY LTNPALKNVT LYQDWDIVID
910 920 930 940 950
DSADVSLAST LQLYQKKNYD KYRRFVLIHE LKNELTPVNG LDIVDYDEFK
960
ETFMRAIGLK
Length:960
Mass (Da):108,726
Last modified:February 1, 1996 - v1
Checksum:iE92C16BBD0D5957C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92382.1.
PIRiT37916.
RefSeqiNP_593666.1. NM_001019098.2.

Genome annotation databases

EnsemblFungiiSPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c.
GeneIDi2542239.
KEGGispo:SPAC18G6.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92382.1.
PIRiT37916.
RefSeqiNP_593666.1. NM_001019098.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RSNNMR-A1-75[»]
3G7LX-ray2.20A15-75[»]
3TIXX-ray2.90B/D504-960[»]
ProteinModelPortaliQ10103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278711. 113 interactions.
DIPiDIP-29301N.
IntActiQ10103. 3 interactions.
MINTiMINT-4696926.

Proteomic databases

MaxQBiQ10103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c.
GeneIDi2542239.
KEGGispo:SPAC18G6.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC18G6.02c.
PomBaseiSPAC18G6.02c. chp1.

Phylogenomic databases

InParanoidiQ10103.
OrthoDBiEOG092C3CYC.

Miscellaneous databases

EvolutionaryTraceiQ10103.
PROiQ10103.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHP1_SCHPO
AccessioniPrimary (citable) accession number: Q10103
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.