Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q10075

- PCS_SCHPO

UniProt

Q10075 - PCS_SCHPO

Protein

Glutathione gamma-glutamylcysteinyltransferase

Gene

SPAC3H1.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for detoxification of heavy metals such as cadmium and arsenate.2 Publications

    Catalytic activityi

    Glutathione + (Glu(-Cys))(n)-Gly = Gly + (Glu(-Cys))(n+1)-Gly.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cadmium ion binding Source: PomBase
    2. glutathione gamma-glutamylcysteinyltransferase activity Source: PomBase

    GO - Biological processi

    1. cellular response to arsenic-containing substance Source: PomBase
    2. cellular response to cadmium ion Source: PomBase
    3. phytochelatin biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione gamma-glutamylcysteinyltransferase (EC:2.3.2.15)
    Alternative name(s):
    Phytochelatin synthase
    Gene namesi
    ORF Names:SPAC3H1.10
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3H1.10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Glutathione gamma-glutamylcysteinyltransferasePRO_0000116449Add
    BLAST

    Proteomic databases

    MaxQBiQ10075.

    Expressioni

    Inductioni

    By cadmium, copper and zinc.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi279789. 5 interactions.
    MINTiMINT-4696717.
    STRINGi4896.SPAC3H1.10-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10075.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 256220Peptidase C83PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phytochelatin synthase family.PROSITE-ProRule annotation
    Contains 1 peptidase C83 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG76926.
    HOGENOMiHOG000209121.
    KOiK05941.
    OMAiKIMAISF.
    OrthoDBiEOG7GFBFP.
    PhylomeDBiQ10075.

    Family and domain databases

    InterProiIPR007719. Phytochelatin_synthase.
    [Graphical view]
    PfamiPF05023. Phytochelatin. 1 hit.
    [Graphical view]
    PROSITEiPS51443. PCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIVKRAVPE LLRGMTNATP NIGLIKNKVV SFEAVGQLKK SFYKRQLPKQ    50
    CLAFDSSLGK DVFLRALQEG RMENYFSLAQ QMVTQNEPAF CGLGTLCMIL 100
    NSLKVDPGRL WKGSWRWYDQ YMLDCCRSLS DIEKDGVTLE EFSCLANCNG 150
    LRTITKCVKD VSFDEFRKDV ISCSTIENKI MAISFCRKVL GQTGDGHFSP 200
    VGGFSESDNK ILILDVARFK YPCYWVDLKL MYESMFPIDK ASGQPRGYVL 250
    LEPMHIPLGV LTVGLNKYSW RNVSKHILQQ AATVKNADNL AEILLSINQS 300
    SIPLIQERSN SSKSGDFEHF KECIRSTKTY HLFLKHTNTN VEYITMAFWA 350
    IFSLPMIQKA LPKGVLEEIQ SLLKEVEISE INTQLTALKK QLDSLTHCCK 400
    TDTGCCSSSC CKNT 414
    Length:414
    Mass (Da):46,741
    Last modified:February 1, 1996 - v1
    Checksum:i4EAB522E9C322EBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92263.1.
    PIRiT38742.
    RefSeqiNP_593552.1. NM_001018985.2.

    Genome annotation databases

    EnsemblFungiiSPAC3H1.10.1; SPAC3H1.10.1:pep; SPAC3H1.10.
    GeneIDi2543367.
    KEGGispo:SPAC3H1.10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92263.1 .
    PIRi T38742.
    RefSeqi NP_593552.1. NM_001018985.2.

    3D structure databases

    ProteinModelPortali Q10075.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279789. 5 interactions.
    MINTi MINT-4696717.
    STRINGi 4896.SPAC3H1.10-1.

    Proteomic databases

    MaxQBi Q10075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3H1.10.1 ; SPAC3H1.10.1:pep ; SPAC3H1.10 .
    GeneIDi 2543367.
    KEGGi spo:SPAC3H1.10.

    Organism-specific databases

    PomBasei SPAC3H1.10.

    Phylogenomic databases

    eggNOGi NOG76926.
    HOGENOMi HOG000209121.
    KOi K05941.
    OMAi KIMAISF.
    OrthoDBi EOG7GFBFP.
    PhylomeDBi Q10075.

    Miscellaneous databases

    NextBioi 20804382.

    Family and domain databases

    InterProi IPR007719. Phytochelatin_synthase.
    [Graphical view ]
    Pfami PF05023. Phytochelatin. 1 hit.
    [Graphical view ]
    PROSITEi PS51443. PCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe."
      Ha S.-B., Smith A.P., Howden R., Dietrich W.M., Bugg S., O'Connell M.J., Goldsbrough P.B., Cobbett C.S.
      Plant Cell 11:1153-1164(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    3. "Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast."
      Clemens S., Kim E.J., Neumann D., Schroeder J.I.
      EMBO J. 18:3325-3333(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPCS_SCHPO
    AccessioniPrimary (citable) accession number: Q10075
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3