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Q10075 (PCS_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione gamma-glutamylcysteinyltransferase

EC=2.3.2.15
Alternative name(s):
Phytochelatin synthase
Gene names
ORF Names:SPAC3H1.10
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for detoxification of heavy metals such as cadmium and arsenate. Ref.2 Ref.3

Catalytic activity

Glutathione + (Glu(-Cys))(n)-Gly = Gly + (Glu(-Cys))(n+1)-Gly.

Induction

By cadmium, copper and zinc. Ref.2

Sequence similarities

Belongs to the phytochelatin synthase family.

Contains 1 peptidase C83 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Glutathione gamma-glutamylcysteinyltransferase
PRO_0000116449

Regions

Domain37 – 256220Peptidase C83

Sequences

Sequence LengthMass (Da)Tools
Q10075 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4EAB522E9C322EBD

FASTA41446,741
        10         20         30         40         50         60 
MNIVKRAVPE LLRGMTNATP NIGLIKNKVV SFEAVGQLKK SFYKRQLPKQ CLAFDSSLGK 

        70         80         90        100        110        120 
DVFLRALQEG RMENYFSLAQ QMVTQNEPAF CGLGTLCMIL NSLKVDPGRL WKGSWRWYDQ 

       130        140        150        160        170        180 
YMLDCCRSLS DIEKDGVTLE EFSCLANCNG LRTITKCVKD VSFDEFRKDV ISCSTIENKI 

       190        200        210        220        230        240 
MAISFCRKVL GQTGDGHFSP VGGFSESDNK ILILDVARFK YPCYWVDLKL MYESMFPIDK 

       250        260        270        280        290        300 
ASGQPRGYVL LEPMHIPLGV LTVGLNKYSW RNVSKHILQQ AATVKNADNL AEILLSINQS 

       310        320        330        340        350        360 
SIPLIQERSN SSKSGDFEHF KECIRSTKTY HLFLKHTNTN VEYITMAFWA IFSLPMIQKA 

       370        380        390        400        410 
LPKGVLEEIQ SLLKEVEISE INTQLTALKK QLDSLTHCCK TDTGCCSSSC CKNT 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe."
Ha S.-B., Smith A.P., Howden R., Dietrich W.M., Bugg S., O'Connell M.J., Goldsbrough P.B., Cobbett C.S.
Plant Cell 11:1153-1164(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[3]"Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast."
Clemens S., Kim E.J., Neumann D., Schroeder J.I.
EMBO J. 18:3325-3333(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA92263.1.
PIRT38742.
RefSeqNP_593552.1. NM_001018985.2.

3D structure databases

ProteinModelPortalQ10075.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279789. 5 interactions.
MINTMINT-4696717.
STRING4896.SPAC3H1.10-1.

Proteomic databases

MaxQBQ10075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC3H1.10.1; SPAC3H1.10.1:pep; SPAC3H1.10.
GeneID2543367.
KEGGspo:SPAC3H1.10.

Organism-specific databases

PomBaseSPAC3H1.10.

Phylogenomic databases

eggNOGNOG76926.
HOGENOMHOG000209121.
KOK05941.
OMAKIMAISF.
OrthoDBEOG7GFBFP.
PhylomeDBQ10075.

Family and domain databases

InterProIPR007719. Phytochelatin_synthase.
[Graphical view]
PfamPF05023. Phytochelatin. 1 hit.
[Graphical view]
PROSITEPS51443. PCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804382.

Entry information

Entry namePCS_SCHPO
AccessionPrimary (citable) accession number: Q10075
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries