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Protein

Glutathione gamma-glutamylcysteinyltransferase

Gene

SPAC3H1.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for detoxification of heavy metals such as cadmium and arsenate.2 Publications

Catalytic activityi

Glutathione + (Glu(-Cys))(n)-Gly = Gly + (Glu(-Cys))(n+1)-Gly.PROSITE-ProRule annotation

GO - Molecular functioni

  • cadmium ion binding Source: PomBase
  • glutathione gamma-glutamylcysteinyltransferase activity Source: PomBase

GO - Biological processi

  • cellular detoxification of cadmium ion Source: PomBase
  • cellular response to cadmium ion Source: PomBase
  • detoxification of copper ion Source: PomBase
  • phytochelatin biosynthetic process Source: PomBase

Keywordsi

Molecular functionTransferase
LigandCadmium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione gamma-glutamylcysteinyltransferase (EC:2.3.2.15)
Alternative name(s):
Phytochelatin synthase
Gene namesi
ORF Names:SPAC3H1.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H1.10
PomBaseiSPAC3H1.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001164491 – 414Glutathione gamma-glutamylcysteinyltransferaseAdd BLAST414

Proteomic databases

MaxQBiQ10075
PaxDbiQ10075
PRIDEiQ10075

PTM databases

iPTMnetiQ10075

Expressioni

Inductioni

By cadmium, copper and zinc.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi279789, 4 interactors
STRINGi4896.SPAC3H1.10.1

Structurei

3D structure databases

ProteinModelPortaliQ10075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 256Peptidase C83PROSITE-ProRule annotationAdd BLAST220

Sequence similaritiesi

Belongs to the phytochelatin synthase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000209121
InParanoidiQ10075
KOiK05941
OrthoDBiEOG092C3AHE
PhylomeDBiQ10075

Family and domain databases

Gene3Di3.90.70.30, 1 hit
InterProiView protein in InterPro
IPR007719 PCS_N
IPR038156 PCS_N_sf
PfamiView protein in Pfam
PF05023 Phytochelatin, 1 hit
PROSITEiView protein in PROSITE
PS51443 PCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q10075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVKRAVPE LLRGMTNATP NIGLIKNKVV SFEAVGQLKK SFYKRQLPKQ
60 70 80 90 100
CLAFDSSLGK DVFLRALQEG RMENYFSLAQ QMVTQNEPAF CGLGTLCMIL
110 120 130 140 150
NSLKVDPGRL WKGSWRWYDQ YMLDCCRSLS DIEKDGVTLE EFSCLANCNG
160 170 180 190 200
LRTITKCVKD VSFDEFRKDV ISCSTIENKI MAISFCRKVL GQTGDGHFSP
210 220 230 240 250
VGGFSESDNK ILILDVARFK YPCYWVDLKL MYESMFPIDK ASGQPRGYVL
260 270 280 290 300
LEPMHIPLGV LTVGLNKYSW RNVSKHILQQ AATVKNADNL AEILLSINQS
310 320 330 340 350
SIPLIQERSN SSKSGDFEHF KECIRSTKTY HLFLKHTNTN VEYITMAFWA
360 370 380 390 400
IFSLPMIQKA LPKGVLEEIQ SLLKEVEISE INTQLTALKK QLDSLTHCCK
410
TDTGCCSSSC CKNT
Length:414
Mass (Da):46,741
Last modified:February 1, 1996 - v1
Checksum:i4EAB522E9C322EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92263.1
PIRiT38742
RefSeqiNP_593552.1, NM_001018985.2

Genome annotation databases

EnsemblFungiiSPAC3H1.10.1; SPAC3H1.10.1:pep; SPAC3H1.10
GeneIDi2543367
KEGGispo:SPAC3H1.10

Similar proteinsi

Entry informationi

Entry nameiPCS_SCHPO
AccessioniPrimary (citable) accession number: Q10075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health