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Protein

Arginase

Gene

aru1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (aru1), Arginase (car1)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Manganese 1PROSITE-ProRule annotation1
Metal bindingi142Manganese 1PROSITE-ProRule annotation1
Metal bindingi142Manganese 2PROSITE-ProRule annotation1
Metal bindingi144Manganese 2PROSITE-ProRule annotation1
Metal bindingi146Manganese 1PROSITE-ProRule annotation1
Binding sitei198SubstrateBy similarity1
Metal bindingi247Manganese 1PROSITE-ProRule annotation1
Metal bindingi247Manganese 2PROSITE-ProRule annotation1
Metal bindingi249Manganese 2PROSITE-ProRule annotation1
Binding sitei261SubstrateBy similarity1
Binding sitei292SubstrateBy similarity1

GO - Molecular functioni

  • arginase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • arginine catabolic process to ornithine Source: PomBase
  • arginine catabolic process to proline via ornithine Source: PomBase
  • urea cycle Source: PomBase

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism, Urea cycle
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-70635 Urea cycle
UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1By similarity)
Gene namesi
Name:aru1
ORF Names:SPAC3H1.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H1.07
PomBaseiSPAC3H1.07 aru1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737101 – 323ArginaseAdd BLAST323

Proteomic databases

MaxQBiQ10066
PaxDbiQ10066
PRIDEiQ10066

PTM databases

iPTMnetiQ10066

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi279799, 17 interactors
STRINGi4896.SPAC3H1.07.1

Structurei

3D structure databases

ProteinModelPortaliQ10066
SMRiQ10066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 148Substrate bindingBy similarity5
Regioni155 – 157Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000204319
InParanoidiQ10066
KOiK01476
OMAiSAVARHC
OrthoDBiEOG092C3GMN
PhylomeDBiQ10066

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPHKISDNH RHLMLSRFMM GNGVSIINMP FSGGQPKDGA ELAPEMVEKA
60 70 80 90 100
GLVDDLEHLG YDVKLIQNPE FKSRPSKEGP NQALMKNPLY VSNVTRQVRD
110 120 130 140 150
AVQRELEQQR VVVNIGGDHS LAIGTVEGVQ AVYDDACVLW IDAHADINTP
160 170 180 190 200
ESSPSKNLHG CPLSFSLGYA EPLPEEFAWT KRVIEERRLA FIGLRDLDPM
210 220 230 240 250
ERAFLRERNI AAYTMHHVDK YGIGRVVEMA MEHINPGKRR PVHLSFDVDA
260 270 280 290 300
CDPIVAPATG TRVPGGLTFR EAMYICEAVA ESGTLVAVDV MEVNPLLGNE
310 320
EEAKTTVDLA RSIVRTSLGQ TLL
Length:323
Mass (Da):35,704
Last modified:February 1, 1996 - v1
Checksum:i1E10876E0E969D66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278A → R in AAA65456 (Ref. 1) Curated1
Sequence conflicti293 – 294Missing in AAA65456 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24279 Genomic DNA Translation: AAA65456.1
CU329670 Genomic DNA Translation: CAA92260.1
PIRiT38739
T52537
RefSeqiNP_593549.1, NM_001018982.2

Genome annotation databases

EnsemblFungiiSPAC3H1.07.1; SPAC3H1.07.1:pep; SPAC3H1.07
GeneIDi2543377
KEGGispo:SPAC3H1.07

Similar proteinsi

Entry informationi

Entry nameiARGI2_SCHPO
AccessioniPrimary (citable) accession number: Q10066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health