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Protein

Arginase

Gene

aru1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (aru1), Arginase (car1)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Manganese 1PROSITE-ProRule annotation1
Metal bindingi142Manganese 1PROSITE-ProRule annotation1
Metal bindingi142Manganese 2PROSITE-ProRule annotation1
Metal bindingi144Manganese 2PROSITE-ProRule annotation1
Metal bindingi146Manganese 1PROSITE-ProRule annotation1
Binding sitei198SubstrateBy similarity1
Metal bindingi247Manganese 1PROSITE-ProRule annotation1
Metal bindingi247Manganese 2PROSITE-ProRule annotation1
Metal bindingi249Manganese 2PROSITE-ProRule annotation1
Binding sitei261SubstrateBy similarity1
Binding sitei292SubstrateBy similarity1

GO - Molecular functioni

  • arginase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • arginine catabolic process to ornithine Source: PomBase
  • arginine catabolic process to proline via ornithine Source: PomBase
  • urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-70635. Urea cycle.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1By similarity)
Gene namesi
Name:aru1
ORF Names:SPAC3H1.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3H1.07.
PomBaseiSPAC3H1.07. aru1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737101 – 323ArginaseAdd BLAST323

Proteomic databases

MaxQBiQ10066.
PRIDEiQ10066.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi279799. 17 interactors.
MINTiMINT-4696665.

Structurei

3D structure databases

ProteinModelPortaliQ10066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 148Substrate bindingBy similarity5
Regioni155 – 157Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000204319.
InParanoidiQ10066.
KOiK01476.
OMAiGMPLGMV.
OrthoDBiEOG092C3GMN.
PhylomeDBiQ10066.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPHKISDNH RHLMLSRFMM GNGVSIINMP FSGGQPKDGA ELAPEMVEKA
60 70 80 90 100
GLVDDLEHLG YDVKLIQNPE FKSRPSKEGP NQALMKNPLY VSNVTRQVRD
110 120 130 140 150
AVQRELEQQR VVVNIGGDHS LAIGTVEGVQ AVYDDACVLW IDAHADINTP
160 170 180 190 200
ESSPSKNLHG CPLSFSLGYA EPLPEEFAWT KRVIEERRLA FIGLRDLDPM
210 220 230 240 250
ERAFLRERNI AAYTMHHVDK YGIGRVVEMA MEHINPGKRR PVHLSFDVDA
260 270 280 290 300
CDPIVAPATG TRVPGGLTFR EAMYICEAVA ESGTLVAVDV MEVNPLLGNE
310 320
EEAKTTVDLA RSIVRTSLGQ TLL
Length:323
Mass (Da):35,704
Last modified:February 1, 1996 - v1
Checksum:i1E10876E0E969D66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278A → R in AAA65456 (Ref. 1) Curated1
Sequence conflicti293 – 294Missing in AAA65456 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24279 Genomic DNA. Translation: AAA65456.1.
CU329670 Genomic DNA. Translation: CAA92260.1.
PIRiT38739.
T52537.
RefSeqiNP_593549.1. NM_001018982.2.

Genome annotation databases

EnsemblFungiiSPAC3H1.07.1; SPAC3H1.07.1:pep; SPAC3H1.07.
GeneIDi2543377.
KEGGispo:SPAC3H1.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24279 Genomic DNA. Translation: AAA65456.1.
CU329670 Genomic DNA. Translation: CAA92260.1.
PIRiT38739.
T52537.
RefSeqiNP_593549.1. NM_001018982.2.

3D structure databases

ProteinModelPortaliQ10066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279799. 17 interactors.
MINTiMINT-4696665.

Proteomic databases

MaxQBiQ10066.
PRIDEiQ10066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3H1.07.1; SPAC3H1.07.1:pep; SPAC3H1.07.
GeneIDi2543377.
KEGGispo:SPAC3H1.07.

Organism-specific databases

EuPathDBiFungiDB:SPAC3H1.07.
PomBaseiSPAC3H1.07. aru1.

Phylogenomic databases

HOGENOMiHOG000204319.
InParanoidiQ10066.
KOiK01476.
OMAiGMPLGMV.
OrthoDBiEOG092C3GMN.
PhylomeDBiQ10066.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-70635. Urea cycle.

Miscellaneous databases

PROiQ10066.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI2_SCHPO
AccessioniPrimary (citable) accession number: Q10066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.