ID   PPOX_SCHPO              Reviewed;         490 AA.
AC   Q10062;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Protoporphyrinogen oxidase;
DE            Short=PPO;
DE            EC=1.3.3.4;
GN   Name=hem14; ORFNames=SPAC1F5.07c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Catalyzes the 6-electron oxidation of
CC       protoporphyrinogen-IX to form protoporphyrin-IX.
CC   -!- CATALYTIC ACTIVITY: Protoporphyrinogen-IX + 3 O(2) =
CC       protoporphyrin-IX + 3 H(2)O(2).
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC       protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the protoporphyrinogen oxidase family.
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DR   EMBL; CU329670; CAA92235.1; -; Genomic_DNA.
DR   PIR; T38088; T38088.
DR   RefSeq; NP_592866.1; -.
DR   GeneID; 2541631; -.
DR   KEGG; spo:SPAC1F5.07c; -.
DR   NMPDR; fig|4896.1.peg.2836; -.
DR   GeneDB_Spombe; SPAC1F5.07c; -.
DR   OMA; Q10062; ETGISYI.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000601-MON; -.
DR   BRENDA; 1.3.3.4; 653.
DR   ArrayExpress; Q10062; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe.
DR   GO; GO:0004729; F:protoporphyrinogen oxidase activity; IEA:EC.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR004572; Protoporphyrinogen_oxidase.
DR   Pfam; PF01266; DAO; 1.
DR   TIGRFAMs; TIGR00562; proto_IX_ox; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Heme biosynthesis;
KW   Mitochondrion; Oxidoreductase; Porphyrin biosynthesis.
FT   CHAIN         1    490       Protoporphyrinogen oxidase.
FT                                /FTId=PRO_0000116445.
FT   NP_BIND       7     12       FAD (Potential).
SQ   SEQUENCE   490 AA;  53462 MW;  CB679F6A437547AA CRC64;
     MSIAICGGGI AGLSTAFYLA RLIPKCTIDL YEKGPRLGGW LQSVKIPCAD SPTGTVLFEQ
     GPRTLRPAGV AGLANLDLIS KLGIEDKLLR ISSNSPSAKN RYIYYPDRLN EIPSSILGSI
     KSIMQPALRP MPLAMMLEPF RKSKRDSTDE SVGSFMRRRF GKNVTDRVMS AMINGIYAGD
     LNDLSMHSSM FGFLAKIEKK YGNITLGLIR ALLAREILSP AEKALKAALL AEPKTAELSN
     SMKSTSMFAF KEGIETITLS IADELKKMPN VKIHLNKPAK TLVPHKTQSL VDVNGQAYEY
     VVFANSSRNL ENLISCPKME TPTSSVYVVN VYYKDPNVLP IRGFGLLIPS CTPNNPNHVL
     GIVFDSEQNN PENGSKVTVM MGGSAYTKNT SLIPTNPEEA VNNALKALQH TLKISSKPTL
     TNATLQQNCI PQYRVGHQDN LNSLKSWIEK NMGGRILLTG SWYNGVSIGD CIMNGHSTAR
     KLASLMNSSS
//