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Q10062

- PPOX_SCHPO

UniProt

Q10062 - PPOX_SCHPO

Protein

Protoporphyrinogen oxidase

Gene

hem14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401FAD; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126FADBy similarity
    Nucleotide bindingi32 – 332FADBy similarity
    Nucleotide bindingi61 – 644FADBy similarity
    Nucleotide bindingi466 – 4683FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: PomBase

    GO - Biological processi

    1. heme biosynthetic process Source: PomBase
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00324.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase (EC:1.3.3.4)
    Short name:
    PPO
    Gene namesi
    Name:hem14
    ORF Names:SPAC1F5.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1F5.07c.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mitochondrion Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Protoporphyrinogen oxidasePRO_0000116445Add
    BLAST

    Proteomic databases

    MaxQBiQ10062.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4696655.
    STRINGi4896.SPAC1F5.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10062.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1232.
    KOiK00231.
    OMAiISIYLGF.
    OrthoDBiEOG7JQBX8.
    PhylomeDBiQ10062.

    Family and domain databases

    Gene3Di3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q10062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIAICGGGI AGLSTAFYLA RLIPKCTIDL YEKGPRLGGW LQSVKIPCAD    50
    SPTGTVLFEQ GPRTLRPAGV AGLANLDLIS KLGIEDKLLR ISSNSPSAKN 100
    RYIYYPDRLN EIPSSILGSI KSIMQPALRP MPLAMMLEPF RKSKRDSTDE 150
    SVGSFMRRRF GKNVTDRVMS AMINGIYAGD LNDLSMHSSM FGFLAKIEKK 200
    YGNITLGLIR ALLAREILSP AEKALKAALL AEPKTAELSN SMKSTSMFAF 250
    KEGIETITLS IADELKKMPN VKIHLNKPAK TLVPHKTQSL VDVNGQAYEY 300
    VVFANSSRNL ENLISCPKME TPTSSVYVVN VYYKDPNVLP IRGFGLLIPS 350
    CTPNNPNHVL GIVFDSEQNN PENGSKVTVM MGGSAYTKNT SLIPTNPEEA 400
    VNNALKALQH TLKISSKPTL TNATLQQNCI PQYRVGHQDN LNSLKSWIEK 450
    NMGGRILLTG SWYNGVSIGD CIMNGHSTAR KLASLMNSSS 490
    Length:490
    Mass (Da):53,462
    Last modified:February 1, 1996 - v1
    Checksum:iCB679F6A437547AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92235.1.
    PIRiT38088.
    RefSeqiNP_592866.1. NM_001018266.2.

    Genome annotation databases

    EnsemblFungiiSPAC1F5.07c.1; SPAC1F5.07c.1:pep; SPAC1F5.07c.
    GeneIDi2541631.
    KEGGispo:SPAC1F5.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92235.1 .
    PIRi T38088.
    RefSeqi NP_592866.1. NM_001018266.2.

    3D structure databases

    ProteinModelPortali Q10062.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4696655.
    STRINGi 4896.SPAC1F5.07c-1.

    Proteomic databases

    MaxQBi Q10062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1F5.07c.1 ; SPAC1F5.07c.1:pep ; SPAC1F5.07c .
    GeneIDi 2541631.
    KEGGi spo:SPAC1F5.07c.

    Organism-specific databases

    PomBasei SPAC1F5.07c.

    Phylogenomic databases

    eggNOGi COG1232.
    KOi K00231.
    OMAi ISIYLGF.
    OrthoDBi EOG7JQBX8.
    PhylomeDBi Q10062.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .

    Miscellaneous databases

    NextBioi 20802724.
    PROi Q10062.

    Family and domain databases

    Gene3Di 3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPPOX_SCHPO
    AccessioniPrimary (citable) accession number: Q10062
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3