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Q10062

- PPOX_SCHPO

UniProt

Q10062 - PPOX_SCHPO

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Protein

Protoporphyrinogen oxidase

Gene

hem14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401FAD; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126FADBy similarity
Nucleotide bindingi32 – 332FADBy similarity
Nucleotide bindingi61 – 644FADBy similarity
Nucleotide bindingi466 – 4683FADBy similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: PomBase

GO - Biological processi

  1. heme biosynthetic process Source: PomBase
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_262908. Heme biosynthesis.
UniPathwayiUPA00251; UER00324.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase (EC:1.3.3.4)
Short name:
PPO
Gene namesi
Name:hem14
ORF Names:SPAC1F5.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1F5.07c.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrion Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Protoporphyrinogen oxidasePRO_0000116445Add
BLAST

Proteomic databases

MaxQBiQ10062.

Interactioni

Protein-protein interaction databases

MINTiMINT-4696655.
STRINGi4896.SPAC1F5.07c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protoporphyrinogen oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1232.
InParanoidiQ10062.
KOiK00231.
OMAiISIYLGF.
OrthoDBiEOG7JQBX8.
PhylomeDBiQ10062.

Family and domain databases

Gene3Di3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10062-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIAICGGGI AGLSTAFYLA RLIPKCTIDL YEKGPRLGGW LQSVKIPCAD
60 70 80 90 100
SPTGTVLFEQ GPRTLRPAGV AGLANLDLIS KLGIEDKLLR ISSNSPSAKN
110 120 130 140 150
RYIYYPDRLN EIPSSILGSI KSIMQPALRP MPLAMMLEPF RKSKRDSTDE
160 170 180 190 200
SVGSFMRRRF GKNVTDRVMS AMINGIYAGD LNDLSMHSSM FGFLAKIEKK
210 220 230 240 250
YGNITLGLIR ALLAREILSP AEKALKAALL AEPKTAELSN SMKSTSMFAF
260 270 280 290 300
KEGIETITLS IADELKKMPN VKIHLNKPAK TLVPHKTQSL VDVNGQAYEY
310 320 330 340 350
VVFANSSRNL ENLISCPKME TPTSSVYVVN VYYKDPNVLP IRGFGLLIPS
360 370 380 390 400
CTPNNPNHVL GIVFDSEQNN PENGSKVTVM MGGSAYTKNT SLIPTNPEEA
410 420 430 440 450
VNNALKALQH TLKISSKPTL TNATLQQNCI PQYRVGHQDN LNSLKSWIEK
460 470 480 490
NMGGRILLTG SWYNGVSIGD CIMNGHSTAR KLASLMNSSS
Length:490
Mass (Da):53,462
Last modified:February 1, 1996 - v1
Checksum:iCB679F6A437547AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92235.1.
PIRiT38088.
RefSeqiNP_592866.1. NM_001018266.2.

Genome annotation databases

EnsemblFungiiSPAC1F5.07c.1; SPAC1F5.07c.1:pep; SPAC1F5.07c.
GeneIDi2541631.
KEGGispo:SPAC1F5.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92235.1 .
PIRi T38088.
RefSeqi NP_592866.1. NM_001018266.2.

3D structure databases

ProteinModelPortali Q10062.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4696655.
STRINGi 4896.SPAC1F5.07c-1.

Proteomic databases

MaxQBi Q10062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1F5.07c.1 ; SPAC1F5.07c.1:pep ; SPAC1F5.07c .
GeneIDi 2541631.
KEGGi spo:SPAC1F5.07c.

Organism-specific databases

PomBasei SPAC1F5.07c.

Phylogenomic databases

eggNOGi COG1232.
InParanoidi Q10062.
KOi K00231.
OMAi ISIYLGF.
OrthoDBi EOG7JQBX8.
PhylomeDBi Q10062.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .
Reactomei REACT_262908. Heme biosynthesis.

Miscellaneous databases

NextBioi 20802724.
PROi Q10062.

Family and domain databases

Gene3Di 3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPOX_SCHPO
AccessioniPrimary (citable) accession number: Q10062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3