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Q10061 (LHS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein 70 homolog lhs1

EC=3.6.1.3
Gene names
ORF Names:SPAC1F5.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length848 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chaperone required for protein translocation and folding in the endoplasmic reticulum By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Endoplasmic reticulum lumen Ref.2.

Sequence similarities

Belongs to the heat shock protein 70 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 848827Heat shock protein 70 homolog lhs1
PRO_0000013557

Regions

Motif845 – 8484Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3591N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) Potential
Glycosylation4881N-linked (GlcNAc...) Potential
Glycosylation5551N-linked (GlcNAc...) Potential
Glycosylation6321N-linked (GlcNAc...) Potential
Glycosylation6781N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Potential
Glycosylation8171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q10061 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A1983FD4253F38F3

FASTA84894,898
        10         20         30         40         50         60 
MKRSVLTIIL FFSCQFWHAF ASSVLAIDYG TEWTKAALIK PGIPLEIVLT KDTRRKEQSA 

        70         80         90        100        110        120 
VAFKGNERIF GVDASNLATR FPAHSIRNVK ELLDTAGLES VLVQKYQSSY PAIQLVENEE 

       130        140        150        160        170        180 
TTSGISFVIS DEENYSLEEI IAMTMEHYIS LAEEMAHEKI TDLVLTVPPH FNELQRSILL 

       190        200        210        220        230        240 
EAARILNKHV LALIDDNVAV AIEYSLSRSF STDPTYNIIY DSGSGSTSAT VISFDTVEGS 

       250        260        270        280        290        300 
SLGKKQNITR IRALASGFTL KLSGNEINRK LIGFMKNSFY QKHGIDLSHN HRALARLEKE 

       310        320        330        340        350        360 
ALRVKHILSA NSEAIASIEE LADGIDFRLK ITRSVLESLC KDMEDAAVEP INKALKKANL 

       370        380        390        400        410        420 
TFSEINSIIL FGGASRIPFI QSTLADYVSS DKISKNVNAD EASVKGAAFY GASLTKSFRV 

       430        440        450        460        470        480 
KPLIVQDIIN YPYLLSLGTS EYIVALPDST PYGMQHNVTI HNVSTIGKHP SFPLSNNGEL 

       490        500        510        520        530        540 
IGEFTLSNIT DVEKVCACSN KNIQISFSSD RTKGILVPLS AIMTCEHGEL SSKHKLGDRV 

       550        560        570        580        590        600 
KSLFGSHDES GLRNNESYPI GFTYKKYGEM SDNALRLASA KLERRLQIDK SKAAHDNALN 

       610        620        630        640        650        660 
ELETLLYRAQ AMVDDDEFLE FANPEETKIL KNDSVESYDW LIEYGSQSPT SEVTDRYKKL 

       670        680        690        700        710        720 
DDTLKSISFR FDQAKQFNTS LENFKNALER AESLLTNFDV PDYPLNVYDE KDVKRVNSLR 

       730        740        750        760        770        780 
GTSYKKLGNQ YYNDTQWLKD NLDSHLSHTL SEDPLIKVEE LEEKAKRLQE LTYEYLRRSL 

       790        800        810        820        830        840 
QQPKLKAKKG ASSSSTAESK VEDETFTNDI EPTTALNSTS TQETEKSRAS VTQRPSSLQQ 


EIDDSDEL 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA92234.1.
PIRT38089.
RefSeqNP_592867.1. NM_001018267.2.

3D structure databases

ProteinModelPortalQ10061.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278037. 1 interaction.
MINTMINT-4696646.
STRING4896.SPAC1F5.06-1.

Proteomic databases

MaxQBQ10061.
PaxDbQ10061.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1F5.06.1; SPAC1F5.06.1:pep; SPAC1F5.06.
GeneID2541537.
KEGGspo:SPAC1F5.06.

Organism-specific databases

PomBaseSPAC1F5.06.

Phylogenomic databases

eggNOGCOG0443.
KOK09486.
OMAWHAFASS.
OrthoDBEOG7DC2CX.
PhylomeDBQ10061.

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802634.

Entry information

Entry nameLHS1_SCHPO
AccessionPrimary (citable) accession number: Q10061
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names