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Q10061

- LHS1_SCHPO

UniProt

Q10061 - LHS1_SCHPO

Protein

Heat shock protein 70 homolog lhs1

Gene

SPAC1F5.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Chaperone required for protein translocation and folding in the endoplasmic reticulum.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: PomBase
    2. ATPase activity Source: UniProtKB-EC
    3. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to unfolded protein Source: PomBase
    2. chaperone-mediated protein folding Source: PomBase
    3. posttranslational protein targeting to membrane, translocation Source: PomBase
    4. regulation of catalytic activity Source: GOC

    Keywords - Molecular functioni

    Chaperone, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188301. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein 70 homolog lhs1 (EC:3.6.1.3)
    Gene namesi
    ORF Names:SPAC1F5.06
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1F5.06.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum lumen Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 848827Heat shock protein 70 homolog lhs1PRO_0000013557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi678 – 6781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi817 – 8171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ10061.
    PaxDbiQ10061.

    Interactioni

    Protein-protein interaction databases

    BioGridi278037. 1 interaction.
    MINTiMINT-4696646.
    STRINGi4896.SPAC1F5.06-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10061.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi845 – 8484Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    KOiK09486.
    OMAiWHAFASS.
    OrthoDBiEOG7DC2CX.
    PhylomeDBiQ10061.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10061-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRSVLTIIL FFSCQFWHAF ASSVLAIDYG TEWTKAALIK PGIPLEIVLT    50
    KDTRRKEQSA VAFKGNERIF GVDASNLATR FPAHSIRNVK ELLDTAGLES 100
    VLVQKYQSSY PAIQLVENEE TTSGISFVIS DEENYSLEEI IAMTMEHYIS 150
    LAEEMAHEKI TDLVLTVPPH FNELQRSILL EAARILNKHV LALIDDNVAV 200
    AIEYSLSRSF STDPTYNIIY DSGSGSTSAT VISFDTVEGS SLGKKQNITR 250
    IRALASGFTL KLSGNEINRK LIGFMKNSFY QKHGIDLSHN HRALARLEKE 300
    ALRVKHILSA NSEAIASIEE LADGIDFRLK ITRSVLESLC KDMEDAAVEP 350
    INKALKKANL TFSEINSIIL FGGASRIPFI QSTLADYVSS DKISKNVNAD 400
    EASVKGAAFY GASLTKSFRV KPLIVQDIIN YPYLLSLGTS EYIVALPDST 450
    PYGMQHNVTI HNVSTIGKHP SFPLSNNGEL IGEFTLSNIT DVEKVCACSN 500
    KNIQISFSSD RTKGILVPLS AIMTCEHGEL SSKHKLGDRV KSLFGSHDES 550
    GLRNNESYPI GFTYKKYGEM SDNALRLASA KLERRLQIDK SKAAHDNALN 600
    ELETLLYRAQ AMVDDDEFLE FANPEETKIL KNDSVESYDW LIEYGSQSPT 650
    SEVTDRYKKL DDTLKSISFR FDQAKQFNTS LENFKNALER AESLLTNFDV 700
    PDYPLNVYDE KDVKRVNSLR GTSYKKLGNQ YYNDTQWLKD NLDSHLSHTL 750
    SEDPLIKVEE LEEKAKRLQE LTYEYLRRSL QQPKLKAKKG ASSSSTAESK 800
    VEDETFTNDI EPTTALNSTS TQETEKSRAS VTQRPSSLQQ EIDDSDEL 848
    Length:848
    Mass (Da):94,898
    Last modified:February 1, 1996 - v1
    Checksum:iA1983FD4253F38F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92234.1.
    PIRiT38089.
    RefSeqiNP_592867.1. NM_001018267.2.

    Genome annotation databases

    EnsemblFungiiSPAC1F5.06.1; SPAC1F5.06.1:pep; SPAC1F5.06.
    GeneIDi2541537.
    KEGGispo:SPAC1F5.06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92234.1 .
    PIRi T38089.
    RefSeqi NP_592867.1. NM_001018267.2.

    3D structure databases

    ProteinModelPortali Q10061.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278037. 1 interaction.
    MINTi MINT-4696646.
    STRINGi 4896.SPAC1F5.06-1.

    Proteomic databases

    MaxQBi Q10061.
    PaxDbi Q10061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1F5.06.1 ; SPAC1F5.06.1:pep ; SPAC1F5.06 .
    GeneIDi 2541537.
    KEGGi spo:SPAC1F5.06.

    Organism-specific databases

    PomBasei SPAC1F5.06.

    Phylogenomic databases

    eggNOGi COG0443.
    KOi K09486.
    OMAi WHAFASS.
    OrthoDBi EOG7DC2CX.
    PhylomeDBi Q10061.

    Enzyme and pathway databases

    Reactomei REACT_188301. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 20802634.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLHS1_SCHPO
    AccessioniPrimary (citable) accession number: Q10061
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3