Heat shock protein 70 homolog lhs1 precursor - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

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Q10061 (LHS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Heat shock protein 70 homolog lhs1
EC=3.6.1.3

Gene names

ORF Names:

SPAC1F5.06

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length	848 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Chaperone required for protein translocation and folding in the endoplasmic reticulum By similarity.
Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Endoplasmic reticulum lumen Ref.2.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC cellular response to unfolded protein Inferred from sequence orthology. Source: PomBase chaperone-mediated protein folding Non-traceable author statement. Source: PomBase posttranslational protein targeting to membrane, translocation Inferred from sequence orthology. Source: PomBase
Cellular_component	endoplasmic reticulum lumen Inferred from sequence orthology. Source: PomBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC adenyl-nucleotide exchange factor activity Inferred from sequence orthology. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

21

Potential

Chain

827

Heat shock protein 70 homolog lhs1

PRO_0000013557

Regions

Motif

4

Prevents secretion from ER Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q10061 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A1983FD4253F38F3
Show »

848

94,898

        10         20         30         40         50         60 
MKRSVLTIIL FFSCQFWHAF ASSVLAIDYG TEWTKAALIK PGIPLEIVLT KDTRRKEQSA 

        70         80         90        100        110        120 
VAFKGNERIF GVDASNLATR FPAHSIRNVK ELLDTAGLES VLVQKYQSSY PAIQLVENEE 

       130        140        150        160        170        180 
TTSGISFVIS DEENYSLEEI IAMTMEHYIS LAEEMAHEKI TDLVLTVPPH FNELQRSILL 

       190        200        210        220        230        240 
EAARILNKHV LALIDDNVAV AIEYSLSRSF STDPTYNIIY DSGSGSTSAT VISFDTVEGS 

       250        260        270        280        290        300 
SLGKKQNITR IRALASGFTL KLSGNEINRK LIGFMKNSFY QKHGIDLSHN HRALARLEKE 

       310        320        330        340        350        360 
ALRVKHILSA NSEAIASIEE LADGIDFRLK ITRSVLESLC KDMEDAAVEP INKALKKANL 

       370        380        390        400        410        420 
TFSEINSIIL FGGASRIPFI QSTLADYVSS DKISKNVNAD EASVKGAAFY GASLTKSFRV 

       430        440        450        460        470        480 
KPLIVQDIIN YPYLLSLGTS EYIVALPDST PYGMQHNVTI HNVSTIGKHP SFPLSNNGEL 

       490        500        510        520        530        540 
IGEFTLSNIT DVEKVCACSN KNIQISFSSD RTKGILVPLS AIMTCEHGEL SSKHKLGDRV 

       550        560        570        580        590        600 
KSLFGSHDES GLRNNESYPI GFTYKKYGEM SDNALRLASA KLERRLQIDK SKAAHDNALN 

       610        620        630        640        650        660 
ELETLLYRAQ AMVDDDEFLE FANPEETKIL KNDSVESYDW LIEYGSQSPT SEVTDRYKKL 

       670        680        690        700        710        720 
DDTLKSISFR FDQAKQFNTS LENFKNALER AESLLTNFDV PDYPLNVYDE KDVKRVNSLR 

       730        740        750        760        770        780 
GTSYKKLGNQ YYNDTQWLKD NLDSHLSHTL SEDPLIKVEE LEEKAKRLQE LTYEYLRRSL 

       790        800        810        820        830        840 
QQPKLKAKKG ASSSSTAESK VEDETFTNDI EPTTALNSTS TQETEKSRAS VTQRPSSLQQ 


EIDDSDEL

References

[1]

"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.

expand/collapse author list

Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA92234.1.
PIR	T38089.
RefSeq	NP_592867.1. NM_001018267.2.
3D structure databases
ProteinModelPortal	Q10061.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPAC1F5.06-1.
Proteomic databases
PaxDb	Q10061.
PRIDE	Q10061.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC1F5.06.1; SPAC1F5.06.1:pep; SPAC1F5.06.
GeneID	2541537.
KEGG	spo:SPAC1F5.06.
Organism-specific databases
PomBase	SPAC1F5.06.
Phylogenomic databases
eggNOG	COG0443.
KO	K09486.
OrthoDB	EOG4H1F3X.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. False negative. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20802634.

Entry information

Entry name

LHS1_SCHPO

Accession

Primary (citable) accession number: Q10061

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents