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Q10057

- PDI1_SCHPO

UniProt

Q10057 - PDI1_SCHPO

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Protein
Putative protein disulfide-isomerase C1F5.02
Gene
SPAC1F5.02
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Nucleophile By similarity
Sitei52 – 521Contributes to redox potential value By similarity
Sitei53 – 531Contributes to redox potential value By similarity
Active sitei54 – 541Nucleophile By similarity
Sitei114 – 1141Lowers pKa of C-terminal Cys of first active site By similarity
Active sitei385 – 3851Nucleophile By similarity
Sitei386 – 3861Contributes to redox potential value By similarity
Sitei387 – 3871Contributes to redox potential value By similarity
Active sitei388 – 3881Nucleophile By similarity
Sitei448 – 4481Lowers pKa of C-terminal Cys of second active site By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: PomBase
  2. protein disulfide oxidoreductase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. oxidation-reduction process Source: GOC
  3. protein folding Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein disulfide-isomerase C1F5.02 (EC:5.3.4.1)
Gene namesi
ORF Names:SPAC1F5.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1F5.02.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum lumen Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 492470Putative protein disulfide-isomerase C1F5.02
PRO_0000034216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 54Redox-active By similarity
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi257 – 2571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi385 ↔ 388Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ10057.
PaxDbiQ10057.

Interactioni

Protein-protein interaction databases

BioGridi277962. 3 interactions.
MINTiMINT-4696595.
STRINGi4896.SPAC1F5.02-1.

Structurei

3D structure databases

ProteinModelPortaliQ10057.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 128106Thioredoxin 1
Add
BLAST
Domaini323 – 462140Thioredoxin 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi489 – 4924Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
KOiK09580.
OMAiPAIVLYR.
OrthoDBiEOG71CFZN.
PhylomeDBiQ10057.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10057-1 [UniParc]FASTAAdd to Basket

« Hide

MKISNLLAAF LAFSGGFFCA SAEVPKVNKE GLNELITADK VLMVKFYAPW    50
CGHCKALAPE YESAADELEK DGISLVEVDC TEEGDLCSEY SIRGYPTLNV 100
FKNGKQISQY SGPRKHDALV KYMRKQLLPT VKPISKDTLE NFVEKADDLA 150
VVAFFKDQKL NDTYTEVAEV MKDDFVFAAS DDKELAKSLG SNFPGIVAFT 200
KDAAQDSDKL VYTGDWDPAS IADFIGVSSI PLLDELNQMT FGKYQQSGLP 250
LGIIFYNSTE SRDELYDVFQ PLAKKYQDTL RFAFLDAVRY GAVAKQMNVE 300
SDWPAFVIAN LKSMLKYPFP TTELTAKAMT KFVGDFVDGK LQPKIKSQPI 350
PESQEDLVVL VADNFDDIVM DETKDVLVEF YAPWCGHCKN LAPTYEKLAE 400
EYSDDSNVVV AKIDATENDI SVSISGFPTI MFFKANDKVN PVRYEGDRTL 450
EDLSAFIDKH ASFEPIKKEK ESVPAPDLED QVAVEDEMAD EL 492
Length:492
Mass (Da):54,880
Last modified:February 1, 1996 - v1
Checksum:iC50B592365666667
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1.
PIRiT38093.
RefSeqiNP_592871.1. NM_001018271.2.

Genome annotation databases

EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02.
GeneIDi2541460.
KEGGispo:SPAC1F5.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1 .
PIRi T38093.
RefSeqi NP_592871.1. NM_001018271.2.

3D structure databases

ProteinModelPortali Q10057.
ModBasei Search...

Protein-protein interaction databases

BioGridi 277962. 3 interactions.
MINTi MINT-4696595.
STRINGi 4896.SPAC1F5.02-1.

Proteomic databases

MaxQBi Q10057.
PaxDbi Q10057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1F5.02.1 ; SPAC1F5.02.1:pep ; SPAC1F5.02 .
GeneIDi 2541460.
KEGGi spo:SPAC1F5.02.

Organism-specific databases

PomBasei SPAC1F5.02.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000162459.
KOi K09580.
OMAi PAIVLYR.
OrthoDBi EOG71CFZN.
PhylomeDBi Q10057.

Miscellaneous databases

NextBioi 20802559.
PROi Q10057.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPDI1_SCHPO
AccessioniPrimary (citable) accession number: Q10057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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