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Protein

Putative protein disulfide-isomerase C1F5.02

Gene

SPAC1F5.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51NucleophileBy similarity1
Sitei52Contributes to redox potential valueBy similarity1
Sitei53Contributes to redox potential valueBy similarity1
Active sitei54NucleophileBy similarity1
Sitei114Lowers pKa of C-terminal Cys of first active siteBy similarity1
Active sitei385NucleophileBy similarity1
Sitei386Contributes to redox potential valueBy similarity1
Sitei387Contributes to redox potential valueBy similarity1
Active sitei388NucleophileBy similarity1
Sitei448Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein disulfide-isomerase C1F5.02 (EC:5.3.4.1)
Gene namesi
ORF Names:SPAC1F5.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.02.
PomBaseiSPAC1F5.02.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • endoplasmic reticulum lumen Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003421623 – 492Putative protein disulfide-isomerase C1F5.02Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 54Redox-activePROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi385 ↔ 388Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ10057.
PRIDEiQ10057.

Interactioni

Protein-protein interaction databases

BioGridi277962. 2 interactors.
MINTiMINT-4696595.

Structurei

3D structure databases

ProteinModelPortaliQ10057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 128Thioredoxin 1PROSITE-ProRule annotationAdd BLAST106
Domaini323 – 462Thioredoxin 2PROSITE-ProRule annotationAdd BLAST140

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 492Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000162459.
InParanoidiQ10057.
KOiK09580.
OMAiAPHHEEL.
OrthoDBiEOG092C3SRA.
PhylomeDBiQ10057.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISNLLAAF LAFSGGFFCA SAEVPKVNKE GLNELITADK VLMVKFYAPW
60 70 80 90 100
CGHCKALAPE YESAADELEK DGISLVEVDC TEEGDLCSEY SIRGYPTLNV
110 120 130 140 150
FKNGKQISQY SGPRKHDALV KYMRKQLLPT VKPISKDTLE NFVEKADDLA
160 170 180 190 200
VVAFFKDQKL NDTYTEVAEV MKDDFVFAAS DDKELAKSLG SNFPGIVAFT
210 220 230 240 250
KDAAQDSDKL VYTGDWDPAS IADFIGVSSI PLLDELNQMT FGKYQQSGLP
260 270 280 290 300
LGIIFYNSTE SRDELYDVFQ PLAKKYQDTL RFAFLDAVRY GAVAKQMNVE
310 320 330 340 350
SDWPAFVIAN LKSMLKYPFP TTELTAKAMT KFVGDFVDGK LQPKIKSQPI
360 370 380 390 400
PESQEDLVVL VADNFDDIVM DETKDVLVEF YAPWCGHCKN LAPTYEKLAE
410 420 430 440 450
EYSDDSNVVV AKIDATENDI SVSISGFPTI MFFKANDKVN PVRYEGDRTL
460 470 480 490
EDLSAFIDKH ASFEPIKKEK ESVPAPDLED QVAVEDEMAD EL
Length:492
Mass (Da):54,880
Last modified:February 1, 1996 - v1
Checksum:iC50B592365666667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1.
PIRiT38093.
RefSeqiNP_592871.1. NM_001018271.2.

Genome annotation databases

EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02.
GeneIDi2541460.
KEGGispo:SPAC1F5.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1.
PIRiT38093.
RefSeqiNP_592871.1. NM_001018271.2.

3D structure databases

ProteinModelPortaliQ10057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277962. 2 interactors.
MINTiMINT-4696595.

Proteomic databases

MaxQBiQ10057.
PRIDEiQ10057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02.
GeneIDi2541460.
KEGGispo:SPAC1F5.02.

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.02.
PomBaseiSPAC1F5.02.

Phylogenomic databases

HOGENOMiHOG000162459.
InParanoidiQ10057.
KOiK09580.
OMAiAPHHEEL.
OrthoDBiEOG092C3SRA.
PhylomeDBiQ10057.

Miscellaneous databases

PROiQ10057.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDI1_SCHPO
AccessioniPrimary (citable) accession number: Q10057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.