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Q10057

- PDI1_SCHPO

UniProt

Q10057 - PDI1_SCHPO

Protein

Putative protein disulfide-isomerase C1F5.02

Gene

SPAC1F5.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511NucleophileBy similarity
    Sitei52 – 521Contributes to redox potential valueBy similarity
    Sitei53 – 531Contributes to redox potential valueBy similarity
    Active sitei54 – 541NucleophileBy similarity
    Sitei114 – 1141Lowers pKa of C-terminal Cys of first active siteBy similarity
    Active sitei385 – 3851NucleophileBy similarity
    Sitei386 – 3861Contributes to redox potential valueBy similarity
    Sitei387 – 3871Contributes to redox potential valueBy similarity
    Active sitei388 – 3881NucleophileBy similarity
    Sitei448 – 4481Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: PomBase
    2. protein disulfide oxidoreductase activity Source: PomBase

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. oxidation-reduction process Source: GOC
    3. protein folding Source: PomBase

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein disulfide-isomerase C1F5.02 (EC:5.3.4.1)
    Gene namesi
    ORF Names:SPAC1F5.02
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1F5.02.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum lumen Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 492470Putative protein disulfide-isomerase C1F5.02PRO_0000034216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 54Redox-activePROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi385 ↔ 388Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ10057.
    PaxDbiQ10057.

    Interactioni

    Protein-protein interaction databases

    BioGridi277962. 3 interactions.
    MINTiMINT-4696595.
    STRINGi4896.SPAC1F5.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10057.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 128106Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini323 – 462140Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi489 – 4924Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000162459.
    KOiK09580.
    OMAiPAIVLYR.
    OrthoDBiEOG71CFZN.
    PhylomeDBiQ10057.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10057-1 [UniParc]FASTAAdd to Basket

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    MKISNLLAAF LAFSGGFFCA SAEVPKVNKE GLNELITADK VLMVKFYAPW    50
    CGHCKALAPE YESAADELEK DGISLVEVDC TEEGDLCSEY SIRGYPTLNV 100
    FKNGKQISQY SGPRKHDALV KYMRKQLLPT VKPISKDTLE NFVEKADDLA 150
    VVAFFKDQKL NDTYTEVAEV MKDDFVFAAS DDKELAKSLG SNFPGIVAFT 200
    KDAAQDSDKL VYTGDWDPAS IADFIGVSSI PLLDELNQMT FGKYQQSGLP 250
    LGIIFYNSTE SRDELYDVFQ PLAKKYQDTL RFAFLDAVRY GAVAKQMNVE 300
    SDWPAFVIAN LKSMLKYPFP TTELTAKAMT KFVGDFVDGK LQPKIKSQPI 350
    PESQEDLVVL VADNFDDIVM DETKDVLVEF YAPWCGHCKN LAPTYEKLAE 400
    EYSDDSNVVV AKIDATENDI SVSISGFPTI MFFKANDKVN PVRYEGDRTL 450
    EDLSAFIDKH ASFEPIKKEK ESVPAPDLED QVAVEDEMAD EL 492
    Length:492
    Mass (Da):54,880
    Last modified:February 1, 1996 - v1
    Checksum:iC50B592365666667
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92230.1.
    PIRiT38093.
    RefSeqiNP_592871.1. NM_001018271.2.

    Genome annotation databases

    EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02.
    GeneIDi2541460.
    KEGGispo:SPAC1F5.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA92230.1 .
    PIRi T38093.
    RefSeqi NP_592871.1. NM_001018271.2.

    3D structure databases

    ProteinModelPortali Q10057.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277962. 3 interactions.
    MINTi MINT-4696595.
    STRINGi 4896.SPAC1F5.02-1.

    Proteomic databases

    MaxQBi Q10057.
    PaxDbi Q10057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1F5.02.1 ; SPAC1F5.02.1:pep ; SPAC1F5.02 .
    GeneIDi 2541460.
    KEGGi spo:SPAC1F5.02.

    Organism-specific databases

    PomBasei SPAC1F5.02.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000162459.
    KOi K09580.
    OMAi PAIVLYR.
    OrthoDBi EOG71CFZN.
    PhylomeDBi Q10057.

    Miscellaneous databases

    NextBioi 20802559.
    PROi Q10057.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPDI1_SCHPO
    AccessioniPrimary (citable) accession number: Q10057
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3