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Q10057

- PDI1_SCHPO

UniProt

Q10057 - PDI1_SCHPO

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Protein

Putative protein disulfide-isomerase C1F5.02

Gene

SPAC1F5.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511NucleophileBy similarity
Sitei52 – 521Contributes to redox potential valueBy similarity
Sitei53 – 531Contributes to redox potential valueBy similarity
Active sitei54 – 541NucleophileBy similarity
Sitei114 – 1141Lowers pKa of C-terminal Cys of first active siteBy similarity
Active sitei385 – 3851NucleophileBy similarity
Sitei386 – 3861Contributes to redox potential valueBy similarity
Sitei387 – 3871Contributes to redox potential valueBy similarity
Active sitei388 – 3881NucleophileBy similarity
Sitei448 – 4481Lowers pKa of C-terminal Cys of second active siteBy similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: PomBase
  2. protein disulfide oxidoreductase activity Source: PomBase

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. oxidation-reduction process Source: GOC
  3. protein folding Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein disulfide-isomerase C1F5.02 (EC:5.3.4.1)
Gene namesi
ORF Names:SPAC1F5.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1F5.02.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum lumen Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 492470Putative protein disulfide-isomerase C1F5.02PRO_0000034216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 54Redox-activePROSITE-ProRule annotation
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi385 ↔ 388Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ10057.
PaxDbiQ10057.

Interactioni

Protein-protein interaction databases

BioGridi277962. 3 interactions.
MINTiMINT-4696595.
STRINGi4896.SPAC1F5.02-1.

Structurei

3D structure databases

ProteinModelPortaliQ10057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 128106Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 462140Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi489 – 4924Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000162459.
InParanoidiQ10057.
KOiK09580.
OMAiPAIVLYR.
OrthoDBiEOG71CFZN.
PhylomeDBiQ10057.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10057-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISNLLAAF LAFSGGFFCA SAEVPKVNKE GLNELITADK VLMVKFYAPW
60 70 80 90 100
CGHCKALAPE YESAADELEK DGISLVEVDC TEEGDLCSEY SIRGYPTLNV
110 120 130 140 150
FKNGKQISQY SGPRKHDALV KYMRKQLLPT VKPISKDTLE NFVEKADDLA
160 170 180 190 200
VVAFFKDQKL NDTYTEVAEV MKDDFVFAAS DDKELAKSLG SNFPGIVAFT
210 220 230 240 250
KDAAQDSDKL VYTGDWDPAS IADFIGVSSI PLLDELNQMT FGKYQQSGLP
260 270 280 290 300
LGIIFYNSTE SRDELYDVFQ PLAKKYQDTL RFAFLDAVRY GAVAKQMNVE
310 320 330 340 350
SDWPAFVIAN LKSMLKYPFP TTELTAKAMT KFVGDFVDGK LQPKIKSQPI
360 370 380 390 400
PESQEDLVVL VADNFDDIVM DETKDVLVEF YAPWCGHCKN LAPTYEKLAE
410 420 430 440 450
EYSDDSNVVV AKIDATENDI SVSISGFPTI MFFKANDKVN PVRYEGDRTL
460 470 480 490
EDLSAFIDKH ASFEPIKKEK ESVPAPDLED QVAVEDEMAD EL
Length:492
Mass (Da):54,880
Last modified:February 1, 1996 - v1
Checksum:iC50B592365666667
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1.
PIRiT38093.
RefSeqiNP_592871.1. NM_001018271.2.

Genome annotation databases

EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02.
GeneIDi2541460.
KEGGispo:SPAC1F5.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA92230.1 .
PIRi T38093.
RefSeqi NP_592871.1. NM_001018271.2.

3D structure databases

ProteinModelPortali Q10057.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277962. 3 interactions.
MINTi MINT-4696595.
STRINGi 4896.SPAC1F5.02-1.

Proteomic databases

MaxQBi Q10057.
PaxDbi Q10057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1F5.02.1 ; SPAC1F5.02.1:pep ; SPAC1F5.02 .
GeneIDi 2541460.
KEGGi spo:SPAC1F5.02.

Organism-specific databases

PomBasei SPAC1F5.02.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000162459.
InParanoidi Q10057.
KOi K09580.
OMAi PAIVLYR.
OrthoDBi EOG71CFZN.
PhylomeDBi Q10057.

Miscellaneous databases

NextBioi 20802559.
PROi Q10057.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPDI1_SCHPO
AccessioniPrimary (citable) accession number: Q10057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3