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Protein

Putative protein disulfide-isomerase C1F5.02

Gene

SPAC1F5.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51NucleophileBy similarity1
Sitei52Contributes to redox potential valueBy similarity1
Sitei53Contributes to redox potential valueBy similarity1
Active sitei54NucleophileBy similarity1
Sitei114Lowers pKa of C-terminal Cys of first active siteBy similarity1
Active sitei385NucleophileBy similarity1
Sitei386Contributes to redox potential valueBy similarity1
Sitei387Contributes to redox potential valueBy similarity1
Active sitei388NucleophileBy similarity1
Sitei448Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-SPO-901042 Calnexin/calreticulin cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein disulfide-isomerase C1F5.02 (EC:5.3.4.1)
Gene namesi
ORF Names:SPAC1F5.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.02
PomBaseiSPAC1F5.02

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003421623 – 492Putative protein disulfide-isomerase C1F5.02Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 54Redox-activePROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi385 ↔ 388Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ10057
PaxDbiQ10057
PRIDEiQ10057

PTM databases

iPTMnetiQ10057

Interactioni

Protein-protein interaction databases

BioGridi277962, 2 interactors
STRINGi4896.SPAC1F5.02.1

Structurei

3D structure databases

ProteinModelPortaliQ10057
SMRiQ10057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 128Thioredoxin 1PROSITE-ProRule annotationAdd BLAST106
Domaini323 – 462Thioredoxin 2PROSITE-ProRule annotationAdd BLAST140

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 492Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000162459
InParanoidiQ10057
KOiK09580
OMAiVAIVKMD
OrthoDBiEOG092C3SRA
PhylomeDBiQ10057

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISNLLAAF LAFSGGFFCA SAEVPKVNKE GLNELITADK VLMVKFYAPW
60 70 80 90 100
CGHCKALAPE YESAADELEK DGISLVEVDC TEEGDLCSEY SIRGYPTLNV
110 120 130 140 150
FKNGKQISQY SGPRKHDALV KYMRKQLLPT VKPISKDTLE NFVEKADDLA
160 170 180 190 200
VVAFFKDQKL NDTYTEVAEV MKDDFVFAAS DDKELAKSLG SNFPGIVAFT
210 220 230 240 250
KDAAQDSDKL VYTGDWDPAS IADFIGVSSI PLLDELNQMT FGKYQQSGLP
260 270 280 290 300
LGIIFYNSTE SRDELYDVFQ PLAKKYQDTL RFAFLDAVRY GAVAKQMNVE
310 320 330 340 350
SDWPAFVIAN LKSMLKYPFP TTELTAKAMT KFVGDFVDGK LQPKIKSQPI
360 370 380 390 400
PESQEDLVVL VADNFDDIVM DETKDVLVEF YAPWCGHCKN LAPTYEKLAE
410 420 430 440 450
EYSDDSNVVV AKIDATENDI SVSISGFPTI MFFKANDKVN PVRYEGDRTL
460 470 480 490
EDLSAFIDKH ASFEPIKKEK ESVPAPDLED QVAVEDEMAD EL
Length:492
Mass (Da):54,880
Last modified:February 1, 1996 - v1
Checksum:iC50B592365666667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92230.1
PIRiT38093
RefSeqiNP_592871.1, NM_001018271.2

Genome annotation databases

EnsemblFungiiSPAC1F5.02.1; SPAC1F5.02.1:pep; SPAC1F5.02
GeneIDi2541460
KEGGispo:SPAC1F5.02

Similar proteinsi

Entry informationi

Entry nameiPDI1_SCHPO
AccessioniPrimary (citable) accession number: Q10057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health