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Protein

Serine/threonine-protein kinase shk2

Gene

shk2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei343 – 3431ATPPROSITE-ProRule annotation
Active sitei434 – 4341Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi315 – 3239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase shk2 (EC:2.7.11.1)
Gene namesi
Name:shk2
ORF Names:SPAC1F5.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.09c.
PomBaseiSPAC1F5.09c. shk2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Serine/threonine-protein kinase shk2PRO_0000086652Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi277970. 48 interactions.
MINTiMINT-4696577.

Structurei

3D structure databases

ProteinModelPortaliQ10056.
SMRiQ10056. Positions 296-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 125103PHPROSITE-ProRule annotationAdd
BLAST
Domaini129 – 14214CRIBPROSITE-ProRule annotationAdd
BLAST
Domaini309 – 566258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000234202.
InParanoidiQ10056.
KOiK08286.
OMAiKANTHIN.
OrthoDBiEOG708W7W.
PhylomeDBiQ10056.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSVRGVPV EIPSLKDTKK SKGIIRSGWV MLKEDKMKYL PWTKKWLVLS
60 70 80 90 100
SNSLSIYKGS KSESAQVTLL LKDIQKVERS KSRTFCFKLR FKSSTKNFEI
110 120 130 140 150
QACELSVADN MECYEWMDLI SSRALASKVS SPMNPKHQVH VGIDNEGNYV
160 170 180 190 200
GLPKEWILLL QSSSITKQEC MEEPKAVIQA LDFYSKQLDT TSETKDSFSF
210 220 230 240 250
CKETLPRSST TSYSIRDADK HHKLTTSGVT KMNITERCKP KTTIQTDKKH
260 270 280 290 300
IIRPFIEDKS HVESIMTGKV TKVPVKADSK NTLSRRMTDR QALAMLKDSV
310 320 330 340 350
TSHDPVEYFN VKHKLGQGAS GSVYLAKVVG GKQLGIFDSV AIKSIDLQCQ
360 370 380 390 400
TRKELILNEI TVMRESIHPN IVTYLDSFLV RERHLWVVME YMNAGSLTDI
410 420 430 440 450
IEKSKLTEAQ IARICLETCK GIQHLHARNI IHRDIKSDNV LLDNSGNIKI
460 470 480 490 500
TDFGFCARLS NRTNKRVTMV GTPYWMAPEV VKQNEYGTKV DIWSLGIMII
510 520 530 540 550
EMIENEPPYL REDPIRALYL IAKNGTPTLK KPNLVSKNLK SFLNSCLTID
560 570 580
TIFRATAAEL LTHSFLNQAC PTEDLKSIIF SRKANTHIN
Length:589
Mass (Da):66,765
Last modified:February 1, 1996 - v1
Checksum:iCA8E2190925EC231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45981 Genomic DNA. Translation: AAA87575.1.
CU329670 Genomic DNA. Translation: CAA92237.1.
PIRiT38086.
RefSeqiNP_592864.1. NM_001018264.1.

Genome annotation databases

EnsemblFungiiSPAC1F5.09c.1; SPAC1F5.09c.1:pep; SPAC1F5.09c.
GeneIDi2541468.
KEGGispo:SPAC1F5.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45981 Genomic DNA. Translation: AAA87575.1.
CU329670 Genomic DNA. Translation: CAA92237.1.
PIRiT38086.
RefSeqiNP_592864.1. NM_001018264.1.

3D structure databases

ProteinModelPortaliQ10056.
SMRiQ10056. Positions 296-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277970. 48 interactions.
MINTiMINT-4696577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1F5.09c.1; SPAC1F5.09c.1:pep; SPAC1F5.09c.
GeneIDi2541468.
KEGGispo:SPAC1F5.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.09c.
PomBaseiSPAC1F5.09c. shk2.

Phylogenomic databases

HOGENOMiHOG000234202.
InParanoidiQ10056.
KOiK08286.
OMAiKANTHIN.
OrthoDBiEOG708W7W.
PhylomeDBiQ10056.

Enzyme and pathway databases

BRENDAi2.7.11.1. 5613.

Miscellaneous databases

NextBioi20802567.
PROiQ10056.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00233. PH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast."
    Yang P., Kansra S., Pimental R.A., Gilbreth M., Marcus S.
    J. Biol. Chem. 273:18481-18489(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSHK2_SCHPO
AccessioniPrimary (citable) accession number: Q10056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.