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Protein

Serine/threonine-protein kinase shk2

Gene

shk2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei343ATPPROSITE-ProRule annotation1
Active sitei434Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi315 – 323ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase shk2 (EC:2.7.11.1)
Gene namesi
Name:shk2
ORF Names:SPAC1F5.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.09c
PomBaseiSPAC1F5.09c shk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866521 – 589Serine/threonine-protein kinase shk2Add BLAST589

Proteomic databases

PaxDbiQ10056
PRIDEiQ10056

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi27797048 interactors.
STRINGi4896.SPAC1F5.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ10056
SMRiQ10056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 125PHPROSITE-ProRule annotationAdd BLAST103
Domaini129 – 142CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini309 – 566Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000234202
InParanoidiQ10056
KOiK08286
OMAiKANTHIN
OrthoDBiEOG092C2E30
PhylomeDBiQ10056

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di2.30.29.301 hit
3.90.810.101 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q10056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSVRGVPV EIPSLKDTKK SKGIIRSGWV MLKEDKMKYL PWTKKWLVLS
60 70 80 90 100
SNSLSIYKGS KSESAQVTLL LKDIQKVERS KSRTFCFKLR FKSSTKNFEI
110 120 130 140 150
QACELSVADN MECYEWMDLI SSRALASKVS SPMNPKHQVH VGIDNEGNYV
160 170 180 190 200
GLPKEWILLL QSSSITKQEC MEEPKAVIQA LDFYSKQLDT TSETKDSFSF
210 220 230 240 250
CKETLPRSST TSYSIRDADK HHKLTTSGVT KMNITERCKP KTTIQTDKKH
260 270 280 290 300
IIRPFIEDKS HVESIMTGKV TKVPVKADSK NTLSRRMTDR QALAMLKDSV
310 320 330 340 350
TSHDPVEYFN VKHKLGQGAS GSVYLAKVVG GKQLGIFDSV AIKSIDLQCQ
360 370 380 390 400
TRKELILNEI TVMRESIHPN IVTYLDSFLV RERHLWVVME YMNAGSLTDI
410 420 430 440 450
IEKSKLTEAQ IARICLETCK GIQHLHARNI IHRDIKSDNV LLDNSGNIKI
460 470 480 490 500
TDFGFCARLS NRTNKRVTMV GTPYWMAPEV VKQNEYGTKV DIWSLGIMII
510 520 530 540 550
EMIENEPPYL REDPIRALYL IAKNGTPTLK KPNLVSKNLK SFLNSCLTID
560 570 580
TIFRATAAEL LTHSFLNQAC PTEDLKSIIF SRKANTHIN
Length:589
Mass (Da):66,765
Last modified:February 1, 1996 - v1
Checksum:iCA8E2190925EC231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45981 Genomic DNA Translation: AAA87575.1
CU329670 Genomic DNA Translation: CAA92237.1
PIRiT38086
RefSeqiNP_592864.1, NM_001018264.1

Genome annotation databases

EnsemblFungiiSPAC1F5.09c.1; SPAC1F5.09c.1:pep; SPAC1F5.09c
GeneIDi2541468
KEGGispo:SPAC1F5.09c

Similar proteinsi

Entry informationi

Entry nameiSHK2_SCHPO
AccessioniPrimary (citable) accession number: Q10056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome