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Protein

ATP-dependent RNA helicase fal1

Gene

tif412

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase fal1 (EC:3.6.4.13)
Gene namesi
Name:tif412
Synonyms:fal1
ORF Names:SPAC1F5.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.10
PomBaseiSPAC1F5.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549671 – 394ATP-dependent RNA helicase fal1Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10055
PaxDbiQ10055
PRIDEiQ10055

PTM databases

iPTMnetiQ10055
SwissPalmiQ10055

Interactioni

Protein-protein interaction databases

BioGridi278099, 2 interactors
STRINGi4896.SPAC1F5.10.1

Structurei

3D structure databases

ProteinModelPortaliQ10055
SMRiQ10055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 222Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini233 – 394Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 49Q motifAdd BLAST29
Motifi170 – 173DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000268797
InParanoidiQ10055
KOiK13025
OMAiFGCQALV
OrthoDBiEOG092C2B1L
PhylomeDBiQ10055

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q10055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEIMENVE LTTSEDVNAV SSFEEMNLKE DLLRGIYAYG YETPSAVQSR
60 70 80 90 100
AIIQICKGRD VIAQAQSGTG KTATFSIGIL QSIDLSVRDT QALILSPTRE
110 120 130 140 150
LAVQIQNVVL ALGDHMNVQC HACIGGTSVG NDIKKLDYGQ HVVSGTPGRV
160 170 180 190 200
TDMIRRRNLR TRNVKMLILD EADELLNQGF KEQIYDIYRY LPPGTQVVVV
210 220 230 240 250
SATLPQDVLE MTNKFTTNPV RILVKRDELT LEGLKQYFIA VEKEEWKFDT
260 270 280 290 300
LCDLYDTLTI TQAVIFCNSR RKVDWLTEKM REANFTVTSM HGEMPQKERD
310 320 330 340 350
AIMQDFRQGN SRVLICTDIW ARGIDVQQVS LVINYDLPAN RENYIHRIGR
360 370 380 390
SGRFGRKGVA INFVTNEDVR ILRDIEQYYS TVIDEMPMNI GDMV
Length:394
Mass (Da):44,706
Last modified:February 1, 1996 - v1
Checksum:i499EBC2DC6442349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92238.1
PIRiT38085
RefSeqiNP_592863.1, NM_001018263.2

Genome annotation databases

EnsemblFungiiSPAC1F5.10.1; SPAC1F5.10.1:pep; SPAC1F5.10
GeneIDi2541602
KEGGispo:SPAC1F5.10

Similar proteinsi

Entry informationi

Entry nameiFAL1_SCHPO
AccessioniPrimary (citable) accession number: Q10055
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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