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Protein
Submitted name:

GABA/Glycine Receptor family (See gbr)

Gene

ggr-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.
R-CEL-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Submitted name:
GABA/Glycine Receptor family (See gbr)Imported
Gene namesi
Name:ggr-3Imported
ORF Names:CELE_F09C12.1Imported, F09C12.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF09C12.1; CE46855; WBGene00001588; ggr-3.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei243 – 267HelicalSequence analysisAdd BLAST25
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei306 – 330HelicalSequence analysisAdd BLAST25
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ10052.

Expressioni

Gene expression databases

BgeeiWBGene00001588.

Interactioni

Protein-protein interaction databases

STRINGi6239.F09C12.1.

Structurei

3D structure databases

ProteinModelPortaliQ10052.
SMRiQ10052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 241Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini250 – 332Neur_chan_membInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000016259.
InParanoidiQ10052.
OMAiFRFKRLY.
OrthoDBiEOG091G07NS.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHDVIYMLL ISTVAKEVKT ESLVDPAHCE YNSNHRKSIL TDLLQDYDKT
60 70 80 90 100
MVPSNNSVQV SVELTVQDIS SISEISSSFI ADVWFSQVWY DPRLEYRNIS
110 120 130 140 150
CKTNLSLDSY VSERLWTPNV CFVNSKSTQV HKSPASNILL IIYPNGTVWL
160 170 180 190 200
NYRVQVSAPC SFELSRFPID AQECHLVFES YSYNIAEVRL NWQQWAPVTM
210 220 230 240 250
PPPEDFRLPD FQFYNVTWGK TSNEYTAGMW DQLKVTFRFK RLYGYYVLQM
260 270 280 290 300
YLPTYLSVFI SWIAFWIDTR ALPARITLGV SSLMALTFQF GNIVKNLPRV
310 320 330 340 350
SFVKAIDLWF FVCVAFIFFS LVELAVVGFV DKITEIKRRS RRIKFQRAIA
360 370 380 390 400
GGTIKNDRPV SFRKYSCTSK CNSVRYNINN NDDEELYNIS GETNGNGVSW
410 420 430 440
KNNSSREASA DMGARVDSFA AKAFPAMFAA FNVFYWWYYL SRERN
Length:445
Mass (Da):51,529
Last modified:March 21, 2012 - v3
Checksum:i27E7D0A4BFC33A19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD63061.2.
RefSeqiNP_494951.3. NM_062550.3.
UniGeneiCel.14887.

Genome annotation databases

EnsemblMetazoaiF09C12.1; F09C12.1; WBGene00001588.
GeneIDi191638.
KEGGicel:CELE_F09C12.1.
UCSCiF09C12.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ10052_CAEEL
AccessioniPrimary (citable) accession number: Q10052
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 21, 2012
Last modified: June 7, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported