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Q10045

- UNC50_CAEEL

UniProt

Q10045 - UNC50_CAEEL

Protein

Protein unc-50

Gene

unc-50

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Required for cell surface expression of acetylcholine receptors in body-wall muscles.1 Publication

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein unc-50
    Alternative name(s):
    Uncoordinated protein 50
    Gene namesi
    Name:unc-50
    ORF Names:T07A5.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiT07A5.2; CE36501; WBGene00006785; unc-50.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: WormBase

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Protein unc-50PRO_0000065452Add
    BLAST

    Proteomic databases

    PaxDbiQ10045.
    PRIDEiQ10045.

    Expressioni

    Developmental stagei

    Ubiquitously expressed, from early embryogenesis to adulthood.1 Publication

    Interactioni

    Protein-protein interaction databases

    IntActiQ10045. 2 interactions.
    STRINGi6239.T07A5.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10045.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 115115CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 1426LumenalSequence Analysis
    Topological domaini164 – 19330CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini215 – 2217LumenalSequence Analysis
    Topological domaini243 – 25412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 30126LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the unc-50 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262379.
    GeneTreeiENSGT00390000018553.
    HOGENOMiHOG000193563.
    InParanoidiQ10045.
    OMAiRFQQMDF.
    OrthoDBiEOG74BJSN.
    PhylomeDBiQ10045.

    Family and domain databases

    InterProiIPR007881. UNC-50.
    [Graphical view]
    PANTHERiPTHR12841. PTHR12841. 1 hit.
    PfamiPF05216. UNC-50. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10045-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQPRGSGT QPGPSQSPIS QRNFRYEPAR SGYTSPGQYS TYSTSTADRV    50
    GCLTAVRMSA FAKLSRFTRR LVHIRQMDFE FALWQMLYLL IQPSKVYKNF 100
    IYRKRTKDQF ARDDPAFLVL LALSLLFSSI FYAYALGLEK IGFFTFFLWS 150
    VFVDCIGVGV VIATVLWWVS NRFLRKVRDQ DVEWGYCFDV HLNAFFPMLI 200
    LLHVIVPILY PTLIDSPAFL SILLGNTFWF LAACYYVYIT FLGYTALPIL 250
    HKTQYFLYPI SFIFMFFVAT LTGGWNISRT ALNFYHSRAE PHKFAPQHGG 300
    L 301
    Length:301
    Mass (Da):34,739
    Last modified:January 4, 2005 - v2
    Checksum:i186A5B6AE302DDEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48055 Genomic DNA. Translation: CAA88132.2.
    PIRiT24631.
    RefSeqiNP_499279.2. NM_066878.3.
    UniGeneiCel.22852.

    Genome annotation databases

    EnsemblMetazoaiT07A5.2; T07A5.2; WBGene00006785.
    GeneIDi176443.
    KEGGicel:CELE_T07A5.2.
    UCSCiT07A5.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48055 Genomic DNA. Translation: CAA88132.2 .
    PIRi T24631.
    RefSeqi NP_499279.2. NM_066878.3.
    UniGenei Cel.22852.

    3D structure databases

    ProteinModelPortali Q10045.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q10045. 2 interactions.
    STRINGi 6239.T07A5.2.

    Proteomic databases

    PaxDbi Q10045.
    PRIDEi Q10045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T07A5.2 ; T07A5.2 ; WBGene00006785 .
    GeneIDi 176443.
    KEGGi cel:CELE_T07A5.2.
    UCSCi T07A5.2. c. elegans.

    Organism-specific databases

    CTDi 176443.
    WormBasei T07A5.2 ; CE36501 ; WBGene00006785 ; unc-50.

    Phylogenomic databases

    eggNOGi NOG262379.
    GeneTreei ENSGT00390000018553.
    HOGENOMi HOG000193563.
    InParanoidi Q10045.
    OMAi RFQQMDF.
    OrthoDBi EOG74BJSN.
    PhylomeDBi Q10045.

    Miscellaneous databases

    NextBioi 892606.
    PROi Q10045.

    Family and domain databases

    InterProi IPR007881. UNC-50.
    [Graphical view ]
    PANTHERi PTHR12841. PTHR12841. 1 hit.
    Pfami PF05216. UNC-50. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein."
      Fitzgerald J., Kennedy D., Viseshakul N., Cohen B.N., Mattick J., Bateman J.F., Forsayeth J.R.
      Brain Res. 877:110-123(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50."
      Eimer S., Gottschalk A., Hengartner M., Horvitz H.R., Richmond J., Schafer W.R., Bessereau J.-L.
      EMBO J. 26:4313-4323(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUNC50_CAEEL
    AccessioniPrimary (citable) accession number: Q10045
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3