Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q10045 (UNC50_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein unc-50
Alternative name(s):
Uncoordinated protein 50
Gene names
Name:unc-50
ORF Names:T07A5.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for cell surface expression of acetylcholine receptors in body-wall muscles. Ref.3

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.3.

Developmental stage

Ubiquitously expressed, from early embryogenesis to adulthood. Ref.3

Sequence similarities

Belongs to the unc-50 family.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentGolgi apparatus
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of Golgi membrane

Inferred from direct assay Ref.3. Source: WormBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Protein unc-50
PRO_0000065452

Regions

Topological domain1 – 115115Cytoplasmic Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 1426Lumenal Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 19330Cytoplasmic Potential
Transmembrane194 – 21421Helical; Potential
Topological domain215 – 2217Lumenal Potential
Transmembrane222 – 24221Helical; Potential
Topological domain243 – 25412Cytoplasmic Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 30126Lumenal Potential

Sequences

Sequence LengthMass (Da)Tools
Q10045 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 186A5B6AE302DDEA

FASTA30134,739
        10         20         30         40         50         60 
MSSQPRGSGT QPGPSQSPIS QRNFRYEPAR SGYTSPGQYS TYSTSTADRV GCLTAVRMSA 

        70         80         90        100        110        120 
FAKLSRFTRR LVHIRQMDFE FALWQMLYLL IQPSKVYKNF IYRKRTKDQF ARDDPAFLVL 

       130        140        150        160        170        180 
LALSLLFSSI FYAYALGLEK IGFFTFFLWS VFVDCIGVGV VIATVLWWVS NRFLRKVRDQ 

       190        200        210        220        230        240 
DVEWGYCFDV HLNAFFPMLI LLHVIVPILY PTLIDSPAFL SILLGNTFWF LAACYYVYIT 

       250        260        270        280        290        300 
FLGYTALPIL HKTQYFLYPI SFIFMFFVAT LTGGWNISRT ALNFYHSRAE PHKFAPQHGG 


L 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein."
Fitzgerald J., Kennedy D., Viseshakul N., Cohen B.N., Mattick J., Bateman J.F., Forsayeth J.R.
Brain Res. 877:110-123(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50."
Eimer S., Gottschalk A., Hengartner M., Horvitz H.R., Richmond J., Schafer W.R., Bessereau J.-L.
EMBO J. 26:4313-4323(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48055 Genomic DNA. Translation: CAA88132.2.
PIRT24631.
RefSeqNP_499279.2. NM_066878.3.
UniGeneCel.22852.

3D structure databases

ProteinModelPortalQ10045.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ10045. 2 interactions.
STRING6239.T07A5.2.

Proteomic databases

PaxDbQ10045.
PRIDEQ10045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT07A5.2; T07A5.2; T07A5.2.
GeneID176443.
KEGGcel:CELE_T07A5.2.
UCSCT07A5.2. c. elegans.

Organism-specific databases

CTD176443.
WormBaseT07A5.2; CE36501; WBGene00006785; unc-50.

Phylogenomic databases

eggNOGNOG262379.
HOGENOMHOG000193563.
InParanoidQ10045.
OMAPFYLTLY.
OrthoDBEOG74BJSN.
PhylomeDBQ10045.

Family and domain databases

InterProIPR007881. UNC-50.
[Graphical view]
PANTHERPTHR12841. PTHR12841. 1 hit.
PfamPF05216. UNC-50. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892606.
PROQ10045.

Entry information

Entry nameUNC50_CAEEL
AccessionPrimary (citable) accession number: Q10045
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase