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Protein

Protein unc-50

Gene

unc-50

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for cell surface expression of acetylcholine receptors in body-wall muscles.1 Publication

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • receptor localization to synapse Source: WormBase
  • transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-50
Alternative name(s):
Uncoordinated protein 50
Gene namesi
Name:unc-50
ORF Names:T07A5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07A5.2; CE36501; WBGene00006785; unc-50.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicSequence analysisAdd BLAST115
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 142LumenalSequence analysis6
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 193CytoplasmicSequence analysisAdd BLAST30
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 221LumenalSequence analysis7
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 254CytoplasmicSequence analysisAdd BLAST12
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 301LumenalSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of Golgi membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000654521 – 301Protein unc-50Add BLAST301

Proteomic databases

EPDiQ10045.
PaxDbiQ10045.
PeptideAtlasiQ10045.

PTM databases

iPTMnetiQ10045.

Expressioni

Developmental stagei

Ubiquitously expressed, from early embryogenesis to adulthood.1 Publication

Gene expression databases

BgeeiWBGene00006785.

Interactioni

Protein-protein interaction databases

IntActiQ10045. 2 interactors.
STRINGi6239.T07A5.2.

Structurei

3D structure databases

ProteinModelPortaliQ10045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3012. Eukaryota.
ENOG410XT05. LUCA.
GeneTreeiENSGT00390000018553.
HOGENOMiHOG000193563.
InParanoidiQ10045.
OMAiRFQQMDF.
OrthoDBiEOG091G0DXP.
PhylomeDBiQ10045.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQPRGSGT QPGPSQSPIS QRNFRYEPAR SGYTSPGQYS TYSTSTADRV
60 70 80 90 100
GCLTAVRMSA FAKLSRFTRR LVHIRQMDFE FALWQMLYLL IQPSKVYKNF
110 120 130 140 150
IYRKRTKDQF ARDDPAFLVL LALSLLFSSI FYAYALGLEK IGFFTFFLWS
160 170 180 190 200
VFVDCIGVGV VIATVLWWVS NRFLRKVRDQ DVEWGYCFDV HLNAFFPMLI
210 220 230 240 250
LLHVIVPILY PTLIDSPAFL SILLGNTFWF LAACYYVYIT FLGYTALPIL
260 270 280 290 300
HKTQYFLYPI SFIFMFFVAT LTGGWNISRT ALNFYHSRAE PHKFAPQHGG

L
Length:301
Mass (Da):34,739
Last modified:January 4, 2005 - v2
Checksum:i186A5B6AE302DDEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48055 Genomic DNA. Translation: CAA88132.2.
PIRiT24631.
RefSeqiNP_499279.2. NM_066878.3.
UniGeneiCel.22852.

Genome annotation databases

EnsemblMetazoaiT07A5.2; T07A5.2; WBGene00006785.
GeneIDi176443.
KEGGicel:CELE_T07A5.2.
UCSCiT07A5.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48055 Genomic DNA. Translation: CAA88132.2.
PIRiT24631.
RefSeqiNP_499279.2. NM_066878.3.
UniGeneiCel.22852.

3D structure databases

ProteinModelPortaliQ10045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ10045. 2 interactors.
STRINGi6239.T07A5.2.

PTM databases

iPTMnetiQ10045.

Proteomic databases

EPDiQ10045.
PaxDbiQ10045.
PeptideAtlasiQ10045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT07A5.2; T07A5.2; WBGene00006785.
GeneIDi176443.
KEGGicel:CELE_T07A5.2.
UCSCiT07A5.2. c. elegans.

Organism-specific databases

CTDi176443.
WormBaseiT07A5.2; CE36501; WBGene00006785; unc-50.

Phylogenomic databases

eggNOGiKOG3012. Eukaryota.
ENOG410XT05. LUCA.
GeneTreeiENSGT00390000018553.
HOGENOMiHOG000193563.
InParanoidiQ10045.
OMAiRFQQMDF.
OrthoDBiEOG091G0DXP.
PhylomeDBiQ10045.

Miscellaneous databases

PROiQ10045.

Gene expression databases

BgeeiWBGene00006785.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNC50_CAEEL
AccessioniPrimary (citable) accession number: Q10045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.