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Q10045

- UNC50_CAEEL

UniProt

Q10045 - UNC50_CAEEL

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Protein

Protein unc-50

Gene

unc-50

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for cell surface expression of acetylcholine receptors in body-wall muscles.1 Publication

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-50
Alternative name(s):
Uncoordinated protein 50
Gene namesi
Name:unc-50
ORF Names:T07A5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiT07A5.2; CE36501; WBGene00006785; unc-50.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 115115CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 1426LumenalSequence Analysis
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 19330CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Topological domaini215 – 2217LumenalSequence Analysis
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Topological domaini243 – 25412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 30126LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Protein unc-50PRO_0000065452Add
BLAST

Proteomic databases

PaxDbiQ10045.
PRIDEiQ10045.

Expressioni

Developmental stagei

Ubiquitously expressed, from early embryogenesis to adulthood.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ10045. 2 interactions.
STRINGi6239.T07A5.2.

Structurei

3D structure databases

ProteinModelPortaliQ10045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the unc-50 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262379.
GeneTreeiENSGT00390000018553.
HOGENOMiHOG000193563.
InParanoidiQ10045.
OMAiRFQQMDF.
OrthoDBiEOG74BJSN.
PhylomeDBiQ10045.

Family and domain databases

InterProiIPR007881. UNC-50.
[Graphical view]
PANTHERiPTHR12841. PTHR12841. 1 hit.
PfamiPF05216. UNC-50. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10045-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSQPRGSGT QPGPSQSPIS QRNFRYEPAR SGYTSPGQYS TYSTSTADRV
60 70 80 90 100
GCLTAVRMSA FAKLSRFTRR LVHIRQMDFE FALWQMLYLL IQPSKVYKNF
110 120 130 140 150
IYRKRTKDQF ARDDPAFLVL LALSLLFSSI FYAYALGLEK IGFFTFFLWS
160 170 180 190 200
VFVDCIGVGV VIATVLWWVS NRFLRKVRDQ DVEWGYCFDV HLNAFFPMLI
210 220 230 240 250
LLHVIVPILY PTLIDSPAFL SILLGNTFWF LAACYYVYIT FLGYTALPIL
260 270 280 290 300
HKTQYFLYPI SFIFMFFVAT LTGGWNISRT ALNFYHSRAE PHKFAPQHGG

L
Length:301
Mass (Da):34,739
Last modified:January 4, 2005 - v2
Checksum:i186A5B6AE302DDEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48055 Genomic DNA. Translation: CAA88132.2.
PIRiT24631.
RefSeqiNP_499279.2. NM_066878.3.
UniGeneiCel.22852.

Genome annotation databases

EnsemblMetazoaiT07A5.2; T07A5.2; WBGene00006785.
GeneIDi176443.
KEGGicel:CELE_T07A5.2.
UCSCiT07A5.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48055 Genomic DNA. Translation: CAA88132.2 .
PIRi T24631.
RefSeqi NP_499279.2. NM_066878.3.
UniGenei Cel.22852.

3D structure databases

ProteinModelPortali Q10045.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q10045. 2 interactions.
STRINGi 6239.T07A5.2.

Proteomic databases

PaxDbi Q10045.
PRIDEi Q10045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T07A5.2 ; T07A5.2 ; WBGene00006785 .
GeneIDi 176443.
KEGGi cel:CELE_T07A5.2.
UCSCi T07A5.2. c. elegans.

Organism-specific databases

CTDi 176443.
WormBasei T07A5.2 ; CE36501 ; WBGene00006785 ; unc-50.

Phylogenomic databases

eggNOGi NOG262379.
GeneTreei ENSGT00390000018553.
HOGENOMi HOG000193563.
InParanoidi Q10045.
OMAi RFQQMDF.
OrthoDBi EOG74BJSN.
PhylomeDBi Q10045.

Miscellaneous databases

NextBioi 892606.
PROi Q10045.

Family and domain databases

InterProi IPR007881. UNC-50.
[Graphical view ]
PANTHERi PTHR12841. PTHR12841. 1 hit.
Pfami PF05216. UNC-50. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein."
    Fitzgerald J., Kennedy D., Viseshakul N., Cohen B.N., Mattick J., Bateman J.F., Forsayeth J.R.
    Brain Res. 877:110-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50."
    Eimer S., Gottschalk A., Hengartner M., Horvitz H.R., Richmond J., Schafer W.R., Bessereau J.-L.
    EMBO J. 26:4313-4323(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUNC50_CAEEL
AccessioniPrimary (citable) accession number: Q10045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 4, 2005
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3