Q10040 (YQA4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative zinc protease C28F5.4
EC=3.4.24.-

Gene names

ORF Names:

C28F5.4

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the peptidase M16 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 856	856	Putative zinc protease C28F5.4		PRO_0000074430
Regions
	Compositional bias	519 – 522	4	Poly-Ser
Sites
	Active site	74	1	Proton acceptor By similarity
	Metal binding	71	1	Zinc By similarity
	Metal binding	75	1	Zinc By similarity
	Metal binding	152	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q10040 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: ACD5E8BB9D43E195	FASTA	856	98,262
	10 20 30 40 50 60 MTKKAKRNIV HKRFDSIVKG SQDTKKYRGL ELTNGLRVLL VSDSKTRVSA VALDVKVGHL 70 80 90 100 110 120 MDPWELPGLA HFCEHMLFLG TAKYPSEREY FKYLAANNGD SNAYTDTDHT NYSFEVRSEK 130 140 150 160 170 180 LYGALDRFAQ FFLDPQFTES ATEREVCAVN CEYLDKVNED FWRCLQVERS LSKPGHDYSK 190 200 210 220 230 240 FAIGNKKTLL EDPRTKGIEP RDVLLDFYKN WYSSDIMTCC IVGKESLDVL ESYLGSFKFD 250 260 270 280 290 300 AIKNTRKERK IWKDSPFGPD QLAKRIEIVP IQNTGQVSIK FPFPDLNGEF LSQPGDYIAH 310 320 330 340 350 360 LIGHEGPGSL LSELKRLGWV ISLEADNHTI ASGFGVFSVT MDLSTEGLEH VDDVIQLVFN 370 380 390 400 410 420 FIGFLKSSGP QKWIHDELAE LNAVDFRFDD VKHTMEKASI LAECLHPKIR KNFETALKTS 430 440 450 460 470 480 HHAFNLPEKN EYIPSKFDQK PREPVKSGYP RLISEDEWIQ VWFKQDNEYN SPKQGIMFAL 490 500 510 520 530 540 TTPLVAKKSK NVVAFKSLDT IIEETYNARL AGLECQFESS SSGVQIRVFG YDEKQSLFAK 550 560 570 580 590 600 HLVNRMANFQ VNRLCFDISF ESLKRTLTNH AFSQPHDLSA HFIDLLVVDN IWSKEQLLAV 610 620 630 640 650 660 CDSVTLEDVH GFAIKMLQAF HMELFVHGNS TEKDTLQLSK ELSDILKSVA PNSRPLKRDE 670 680 690 700 710 720 HNPHRELQLI NGHEHVYRHF QKTHDVGCVE VAFQIGVQST YNNSVNKLLN ELIKNPAYTI 730 740 750 760 770 780 LRTNEALGYN VSTESRLNDG NVYLHVIVQG PESADHVLER IEVFLESARE EIVAMPQEDF 790 800 810 820 830 840 DYQVWAMFKE NPPTLSQCFS MFWSEIHSRQ YNFGRNKEVR GISKRITKEE VINFFDRKIR 850 KGGAERRKLA LGLWKK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080699 Genomic DNA. Translation: CCD65926.1.
PIR	T15688.
RefSeq	NP_495575.2. NM_063174.4.
3D structure databases
ProteinModelPortal	Q10040.
SMR	Q10040. Positions 15-851.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.C28F5.4.
Protein family/group databases
MEROPS	M16.A10.
Proteomic databases
PaxDb	Q10040.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C28F5.4; C28F5.4; C28F5.4.
GeneID	182987.
KEGG	cel:CELE_C28F5.4.
UCSC	C28F5.4. c. elegans.
Organism-specific databases
CTD	182987.
WormBase	C28F5.4; CE40024; WBGene00016185.
Phylogenomic databases
eggNOG	COG1025.
GeneTree	ENSGT00530000063327.
HOGENOM	HOG000161331.
InParanoid	Q10040.
KO	K01408.
OMA	WISSAPN.
Family and domain databases
Gene3D	3.30.830.10. 4 hits.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR011237. Pept_M16_dom. IPR011765. Pept_M16_N. IPR001431. Pept_M16_Zn_BS. IPR007863. Peptidase_M16_C. [Graphical view]
Pfam	PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 2 hits. [Graphical view]
SUPFAM	SSF63411. Metalloenz_metal-bd. 4 hits.
PROSITE	PS00143. INSULINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	919532.

Entry information

Entry name

YQA4_CAEEL

Accession

Primary (citable) accession number: Q10040

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project