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Q10038

- VHP1_CAEEL

UniProt

Q10038 - VHP1_CAEEL

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Protein

Tyrosine-protein phosphatase vhp-1

Gene
vhp-1, F08B1.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. JUN kinase phosphatase activity Source: WormBase
  2. MAP kinase tyrosine/serine/threonine phosphatase activity Source: WormBase
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: WormBase
  2. negative regulation of JNK cascade Source: WormBase
  3. nematode larval development Source: WormBase
  4. protein dephosphorylation Source: WormBase
  5. response to copper ion Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiQ10038.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase vhp-1 (EC:3.1.3.48)
Alternative name(s):
Vh1 dual specificity phosphatase family protein 1
Gene namesi
Name:vhp-1
ORF Names:F08B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF08B1.1a; CE27918; WBGene00006923; vhp-1.
F08B1.1b; CE27919; WBGene00006923; vhp-1.
F08B1.1c; CE32357; WBGene00006923; vhp-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Tyrosine-protein phosphatase vhp-1PRO_0000094925Add
BLAST

Proteomic databases

PaxDbiQ10038.
PRIDEiQ10038.

Expressioni

Tissue specificityi

Expressed in the pharynx, intestine, neurons and vulval hypodermal cells.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi39249. 1 interaction.
DIPiDIP-59690N.

Structurei

3D structure databases

ProteinModelPortaliQ10038.
SMRiQ10038. Positions 9-319.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 151131RhodaneseAdd
BLAST
Domaini175 – 317143Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi350 – 565216Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00750000117567.
HOGENOMiHOG000017063.
InParanoidiQ10038.
KOiK04459.
OMAiKRRIASC.
PhylomeDBiQ10038.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q10038-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS    50
KLIRRRLFEN KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK 100
RRIASCNAPE STAKIMRVLR ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC 150
ESSEGMTRLP QSLSQPCLSQ PTGDGITLIT PNIYLGSQID SLDETMLDAL 200
DISVVINLSM TCPKSVCIKE DKNFMRIPVN DSYQEKLSPY FPMAYEFLEK 250
CRRAGKKCLI HCLAGISRSP TLAISYIMRY MKMGSDDAYR YVKERRPSIS 300
PNFNFMGQLL EYENVLIKDH VLDYNQASRP HRHMDYYGPS DLCPPKVPKS 350
ASSNCVFPGS THDESSPSSP SVSEGSAASE PETSSSAASS SSTASAPPSM 400
PSTSEQGTSS GTVNVNGKRN MTMDLGLPHR PKALGLPSRI GTSVAELPSP 450
STELSRLSFN GPEAIAPSTP ILNFTNPCFN SPIIPVASSS REVILTLPTP 500
AASSSSSTSS EPSFDFSSFE SSSSSSIVVE NPFFASTEVP AGSSSISTPS 550
GSQSTPASAS SSAASRCRMK GFFKVFSKKA PASTSTPASS TPGTSRAARP 600
ECLRSSGIII SAPVLAITEE EDAESPESGF NEPEVGEEDD DSVSICSTSS 650
LEIPCHQ 657
Length:657
Mass (Da):71,003
Last modified:June 7, 2005 - v2
Checksum:iA0D9153DE6326B43
GO
Isoform b (identifier: Q10038-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: MTVLDTVTIS...DKFRSVMVLE → MGGQPFEAFR...SPISSSSPTN

Note: No experimental confirmation available.

Show »
Length:606
Mass (Da):64,963
Checksum:i5B71795C6ED58058
GO
Isoform c (identifier: Q10038-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     588-657: ASSTPGTSRA...TSSLEIPCHQ → VSIMKLH

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):46,893
Checksum:iA7FF64BDC46B0774
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 155155Missing in isoform c. VSP_014013Add
BLAST
Alternative sequencei1 – 136136MTVLD…VMVLE → MGGQPFEAFRKNRKRKKTKN KKKRRNNNNSKNKTPNTFPN EIEEQDPVSSLPTFPAKKFG LKLQLTLTSSPTNSSSPISS SSPTN in isoform b. VSP_014014Add
BLAST
Alternative sequencei588 – 65770ASSTP…IPCHQ → VSIMKLH in isoform c. VSP_014015Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY585194 mRNA. Translation: AAS91377.1.
FO081082 Genomic DNA. Translation: CCD68973.1.
FO081082 Genomic DNA. Translation: CCD68974.1.
FO081082 Genomic DNA. Translation: CCD68975.1.
PIRiT15969.
RefSeqiNP_494997.1. NM_062596.4. [Q10038-1]
NP_494998.1. NM_062597.1. [Q10038-2]
NP_871926.1. NM_182126.3. [Q10038-3]
UniGeneiCel.8018.

Genome annotation databases

EnsemblMetazoaiF08B1.1a.1; F08B1.1a.1; WBGene00006923. [Q10038-1]
F08B1.1a.2; F08B1.1a.2; WBGene00006923. [Q10038-1]
F08B1.1a.3; F08B1.1a.3; WBGene00006923. [Q10038-1]
GeneIDi173904.
KEGGicel:CELE_F08B1.1.
UCSCiF08B1.1a.3. c. elegans. [Q10038-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY585194 mRNA. Translation: AAS91377.1 .
FO081082 Genomic DNA. Translation: CCD68973.1 .
FO081082 Genomic DNA. Translation: CCD68974.1 .
FO081082 Genomic DNA. Translation: CCD68975.1 .
PIRi T15969.
RefSeqi NP_494997.1. NM_062596.4. [Q10038-1 ]
NP_494998.1. NM_062597.1. [Q10038-2 ]
NP_871926.1. NM_182126.3. [Q10038-3 ]
UniGenei Cel.8018.

3D structure databases

ProteinModelPortali Q10038.
SMRi Q10038. Positions 9-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39249. 1 interaction.
DIPi DIP-59690N.

Proteomic databases

PaxDbi Q10038.
PRIDEi Q10038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F08B1.1a.1 ; F08B1.1a.1 ; WBGene00006923 . [Q10038-1 ]
F08B1.1a.2 ; F08B1.1a.2 ; WBGene00006923 . [Q10038-1 ]
F08B1.1a.3 ; F08B1.1a.3 ; WBGene00006923 . [Q10038-1 ]
GeneIDi 173904.
KEGGi cel:CELE_F08B1.1.
UCSCi F08B1.1a.3. c. elegans. [Q10038-1 ]

Organism-specific databases

CTDi 173904.
WormBasei F08B1.1a ; CE27918 ; WBGene00006923 ; vhp-1.
F08B1.1b ; CE27919 ; WBGene00006923 ; vhp-1.
F08B1.1c ; CE32357 ; WBGene00006923 ; vhp-1.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00750000117567.
HOGENOMi HOG000017063.
InParanoidi Q10038.
KOi K04459.
OMAi KRRIASC.
PhylomeDBi Q10038.

Enzyme and pathway databases

SignaLinki Q10038.

Miscellaneous databases

NextBioi 881603.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response."
    Mizuno T., Hisamoto N., Terada T., Kondo T., Adachi M., Nishida E., Kim D.H., Ausubel F.M., Matsumoto K.
    EMBO J. 23:2226-2234(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiVHP1_CAEEL
AccessioniPrimary (citable) accession number: Q10038
Secondary accession number(s): Q8IG35, Q8ST18, Q8ST19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi