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Q10038 (VHP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase vhp-1

EC=3.1.3.48
Alternative name(s):
Vh1 dual specificity phosphatase family protein 1
Gene names
Name:vhp-1
ORF Names:F08B1.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Tissue specificity

Expressed in the pharynx, intestine, neurons and vulval hypodermal cells. Ref.1

Developmental stage

Expressed throughout development. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q10038-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: Q10038-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: MTVLDTVTIS...DKFRSVMVLE → MGGQPFEAFR...SPISSSSPTN
Note: No experimental confirmation available.
Isoform c (identifier: Q10038-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     588-657: ASSTPGTSRA...TSSLEIPCHQ → VSIMKLH
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Tyrosine-protein phosphatase vhp-1
PRO_0000094925

Regions

Domain21 – 151131Rhodanese
Domain175 – 317143Tyrosine-protein phosphatase
Compositional bias350 – 565216Ser-rich

Sites

Active site2621Phosphocysteine intermediate By similarity

Natural variations

Alternative sequence1 – 155155Missing in isoform c.
VSP_014013
Alternative sequence1 – 136136MTVLD…VMVLE → MGGQPFEAFRKNRKRKKTKN KKKRRNNNNSKNKTPNTFPN EIEEQDPVSSLPTFPAKKFG LKLQLTLTSSPTNSSSPISS SSPTN in isoform b.
VSP_014014
Alternative sequence588 – 65770ASSTP…IPCHQ → VSIMKLH in isoform c.
VSP_014015

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: A0D9153DE6326B43

FASTA65771,003
        10         20         30         40         50         60 
MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS KLIRRRLFEN 

        70         80         90        100        110        120 
KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK RRIASCNAPE STAKIMRVLR 

       130        140        150        160        170        180 
ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC ESSEGMTRLP QSLSQPCLSQ PTGDGITLIT 

       190        200        210        220        230        240 
PNIYLGSQID SLDETMLDAL DISVVINLSM TCPKSVCIKE DKNFMRIPVN DSYQEKLSPY 

       250        260        270        280        290        300 
FPMAYEFLEK CRRAGKKCLI HCLAGISRSP TLAISYIMRY MKMGSDDAYR YVKERRPSIS 

       310        320        330        340        350        360 
PNFNFMGQLL EYENVLIKDH VLDYNQASRP HRHMDYYGPS DLCPPKVPKS ASSNCVFPGS 

       370        380        390        400        410        420 
THDESSPSSP SVSEGSAASE PETSSSAASS SSTASAPPSM PSTSEQGTSS GTVNVNGKRN 

       430        440        450        460        470        480 
MTMDLGLPHR PKALGLPSRI GTSVAELPSP STELSRLSFN GPEAIAPSTP ILNFTNPCFN 

       490        500        510        520        530        540 
SPIIPVASSS REVILTLPTP AASSSSSTSS EPSFDFSSFE SSSSSSIVVE NPFFASTEVP 

       550        560        570        580        590        600 
AGSSSISTPS GSQSTPASAS SSAASRCRMK GFFKVFSKKA PASTSTPASS TPGTSRAARP 

       610        620        630        640        650 
ECLRSSGIII SAPVLAITEE EDAESPESGF NEPEVGEEDD DSVSICSTSS LEIPCHQ 

« Hide

Isoform b [UniParc].

Checksum: 5B71795C6ED58058
Show »

FASTA60664,963
Isoform c [UniParc].

Checksum: A7FF64BDC46B0774
Show »

FASTA43946,893

References

« Hide 'large scale' references
[1]"The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response."
Mizuno T., Hisamoto N., Terada T., Kondo T., Adachi M., Nishida E., Kim D.H., Ausubel F.M., Matsumoto K.
EMBO J. 23:2226-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY585194 mRNA. Translation: AAS91377.1.
FO081082 Genomic DNA. Translation: CCD68973.1.
FO081082 Genomic DNA. Translation: CCD68974.1.
FO081082 Genomic DNA. Translation: CCD68975.1.
PIRT15969.
RefSeqNP_494997.1. NM_062596.4.
NP_494998.1. NM_062597.1.
NP_871926.1. NM_182126.3.
UniGeneCel.8018.

3D structure databases

ProteinModelPortalQ10038.
SMRQ10038. Positions 9-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39249. 1 interaction.
DIPDIP-59690N.

Proteomic databases

PaxDbQ10038.
PRIDEQ10038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF08B1.1a.1; F08B1.1a.1; F08B1.1. [Q10038-1]
F08B1.1a.2; F08B1.1a.2; F08B1.1. [Q10038-1]
F08B1.1a.3; F08B1.1a.3; F08B1.1. [Q10038-1]
F08B1.1a.4; F08B1.1a.4; F08B1.1. [Q10038-1]
GeneID173904.
KEGGcel:CELE_F08B1.1.
UCSCF08B1.1a.3. c. elegans. [Q10038-1]

Organism-specific databases

CTD173904.
WormBaseF08B1.1a; CE27918; WBGene00006923; vhp-1.
F08B1.1b; CE27919; WBGene00006923; vhp-1.
F08B1.1c; CE32357; WBGene00006923; vhp-1.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000017063.
InParanoidQ10038.
KOK04459.
OMAKRRIASC.
PhylomeDBQ10038.

Enzyme and pathway databases

SignaLinkQ10038.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSPR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 2 hits.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio881603.

Entry information

Entry nameVHP1_CAEEL
AccessionPrimary (citable) accession number: Q10038
Secondary accession number(s): Q8IG35, Q8ST18, Q8ST19
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase