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Q10038

- VHP1_CAEEL

UniProt

Q10038 - VHP1_CAEEL

Protein

Tyrosine-protein phosphatase vhp-1

Gene

vhp-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. JUN kinase phosphatase activity Source: WormBase
    2. MAP kinase tyrosine/serine/threonine phosphatase activity Source: WormBase
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: WormBase
    2. negative regulation of JNK cascade Source: WormBase
    3. nematode larval development Source: WormBase
    4. protein dephosphorylation Source: WormBase
    5. response to copper ion Source: WormBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    SignaLinkiQ10038.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase vhp-1 (EC:3.1.3.48)
    Alternative name(s):
    Vh1 dual specificity phosphatase family protein 1
    Gene namesi
    Name:vhp-1
    ORF Names:F08B1.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF08B1.1a; CE27918; WBGene00006923; vhp-1.
    F08B1.1b; CE27919; WBGene00006923; vhp-1.
    F08B1.1c; CE32357; WBGene00006923; vhp-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Tyrosine-protein phosphatase vhp-1PRO_0000094925Add
    BLAST

    Proteomic databases

    PaxDbiQ10038.
    PRIDEiQ10038.

    Expressioni

    Tissue specificityi

    Expressed in the pharynx, intestine, neurons and vulval hypodermal cells.1 Publication

    Developmental stagei

    Expressed throughout development.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi39249. 1 interaction.
    DIPiDIP-59690N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10038.
    SMRiQ10038. Positions 9-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 151131RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini175 – 317143Tyrosine-protein phosphataseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi350 – 565216Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117567.
    HOGENOMiHOG000017063.
    InParanoidiQ10038.
    KOiK04459.
    OMAiKRRIASC.
    PhylomeDBiQ10038.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 2 hits.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q10038-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS    50
    KLIRRRLFEN KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK 100
    RRIASCNAPE STAKIMRVLR ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC 150
    ESSEGMTRLP QSLSQPCLSQ PTGDGITLIT PNIYLGSQID SLDETMLDAL 200
    DISVVINLSM TCPKSVCIKE DKNFMRIPVN DSYQEKLSPY FPMAYEFLEK 250
    CRRAGKKCLI HCLAGISRSP TLAISYIMRY MKMGSDDAYR YVKERRPSIS 300
    PNFNFMGQLL EYENVLIKDH VLDYNQASRP HRHMDYYGPS DLCPPKVPKS 350
    ASSNCVFPGS THDESSPSSP SVSEGSAASE PETSSSAASS SSTASAPPSM 400
    PSTSEQGTSS GTVNVNGKRN MTMDLGLPHR PKALGLPSRI GTSVAELPSP 450
    STELSRLSFN GPEAIAPSTP ILNFTNPCFN SPIIPVASSS REVILTLPTP 500
    AASSSSSTSS EPSFDFSSFE SSSSSSIVVE NPFFASTEVP AGSSSISTPS 550
    GSQSTPASAS SSAASRCRMK GFFKVFSKKA PASTSTPASS TPGTSRAARP 600
    ECLRSSGIII SAPVLAITEE EDAESPESGF NEPEVGEEDD DSVSICSTSS 650
    LEIPCHQ 657
    Length:657
    Mass (Da):71,003
    Last modified:June 7, 2005 - v2
    Checksum:iA0D9153DE6326B43
    GO
    Isoform b (identifier: Q10038-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-136: MTVLDTVTIS...DKFRSVMVLE → MGGQPFEAFR...SPISSSSPTN

    Note: No experimental confirmation available.

    Show »
    Length:606
    Mass (Da):64,963
    Checksum:i5B71795C6ED58058
    GO
    Isoform c (identifier: Q10038-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-155: Missing.
         588-657: ASSTPGTSRA...TSSLEIPCHQ → VSIMKLH

    Note: No experimental confirmation available.

    Show »
    Length:439
    Mass (Da):46,893
    Checksum:iA7FF64BDC46B0774
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 155155Missing in isoform c. CuratedVSP_014013Add
    BLAST
    Alternative sequencei1 – 136136MTVLD…VMVLE → MGGQPFEAFRKNRKRKKTKN KKKRRNNNNSKNKTPNTFPN EIEEQDPVSSLPTFPAKKFG LKLQLTLTSSPTNSSSPISS SSPTN in isoform b. CuratedVSP_014014Add
    BLAST
    Alternative sequencei588 – 65770ASSTP…IPCHQ → VSIMKLH in isoform c. CuratedVSP_014015Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY585194 mRNA. Translation: AAS91377.1.
    FO081082 Genomic DNA. Translation: CCD68973.1.
    FO081082 Genomic DNA. Translation: CCD68974.1.
    FO081082 Genomic DNA. Translation: CCD68975.1.
    PIRiT15969.
    RefSeqiNP_494997.1. NM_062596.4. [Q10038-1]
    NP_494998.1. NM_062597.1. [Q10038-2]
    NP_871926.1. NM_182126.3. [Q10038-3]
    UniGeneiCel.8018.

    Genome annotation databases

    EnsemblMetazoaiF08B1.1a.1; F08B1.1a.1; WBGene00006923. [Q10038-1]
    F08B1.1a.2; F08B1.1a.2; WBGene00006923. [Q10038-1]
    F08B1.1a.3; F08B1.1a.3; WBGene00006923. [Q10038-1]
    GeneIDi173904.
    KEGGicel:CELE_F08B1.1.
    UCSCiF08B1.1a.3. c. elegans. [Q10038-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY585194 mRNA. Translation: AAS91377.1 .
    FO081082 Genomic DNA. Translation: CCD68973.1 .
    FO081082 Genomic DNA. Translation: CCD68974.1 .
    FO081082 Genomic DNA. Translation: CCD68975.1 .
    PIRi T15969.
    RefSeqi NP_494997.1. NM_062596.4. [Q10038-1 ]
    NP_494998.1. NM_062597.1. [Q10038-2 ]
    NP_871926.1. NM_182126.3. [Q10038-3 ]
    UniGenei Cel.8018.

    3D structure databases

    ProteinModelPortali Q10038.
    SMRi Q10038. Positions 9-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39249. 1 interaction.
    DIPi DIP-59690N.

    Proteomic databases

    PaxDbi Q10038.
    PRIDEi Q10038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F08B1.1a.1 ; F08B1.1a.1 ; WBGene00006923 . [Q10038-1 ]
    F08B1.1a.2 ; F08B1.1a.2 ; WBGene00006923 . [Q10038-1 ]
    F08B1.1a.3 ; F08B1.1a.3 ; WBGene00006923 . [Q10038-1 ]
    GeneIDi 173904.
    KEGGi cel:CELE_F08B1.1.
    UCSCi F08B1.1a.3. c. elegans. [Q10038-1 ]

    Organism-specific databases

    CTDi 173904.
    WormBasei F08B1.1a ; CE27918 ; WBGene00006923 ; vhp-1.
    F08B1.1b ; CE27919 ; WBGene00006923 ; vhp-1.
    F08B1.1c ; CE32357 ; WBGene00006923 ; vhp-1.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117567.
    HOGENOMi HOG000017063.
    InParanoidi Q10038.
    KOi K04459.
    OMAi KRRIASC.
    PhylomeDBi Q10038.

    Enzyme and pathway databases

    SignaLinki Q10038.

    Miscellaneous databases

    NextBioi 881603.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 2 hits.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response."
      Mizuno T., Hisamoto N., Terada T., Kondo T., Adachi M., Nishida E., Kim D.H., Ausubel F.M., Matsumoto K.
      EMBO J. 23:2226-2234(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiVHP1_CAEEL
    AccessioniPrimary (citable) accession number: Q10038
    Secondary accession number(s): Q8IG35, Q8ST18, Q8ST19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3