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Protein

Tyrosine-protein phosphatase vhp-1

Gene

vhp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei262Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • JUN kinase phosphatase activity Source: WormBase
  • MAP kinase tyrosine/serine/threonine phosphatase activity Source: WormBase
  • mitogen-activated protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • determination of adult lifespan Source: UniProtKB
  • inactivation of MAPK activity Source: WormBase
  • negative regulation of axon extension involved in regeneration Source: UniProtKB
  • negative regulation of defense response to bacterium Source: UniProtKB
  • negative regulation of JNK cascade Source: WormBase
  • negative regulation of protein localization to nucleus Source: UniProtKB
  • negative regulation of protein phosphorylation Source: UniProtKB
  • negative regulation of stress response to copper ion Source: WormBase
  • nematode larval development Source: WormBase
  • positive regulation of defense response to bacterium Source: UniProtKB
  • positive regulation of protein localization to nucleus Source: UniProtKB
  • protein dephosphorylation Source: WormBase
  • regulation of protein localization to nucleus Source: UniProtKB
  • response to cadmium ion Source: UniProtKB
  • response to copper ion Source: WormBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-CEL-112409 RAF-independent MAPK1/3 activation
R-CEL-5675221 Negative regulation of MAPK pathway
SignaLinkiQ10038

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase vhp-1 (EC:3.1.3.48)
Alternative name(s):
Vh1 dual specificity phosphatase family protein 1
Gene namesi
Name:vhp-1
ORF Names:F08B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF08B1.1a ; CE27918 ; WBGene00006923 ; vhp-1
F08B1.1b ; CE27919 ; WBGene00006923 ; vhp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi262C → S: Loss of kgb-1 inhibition. No effect on interaction with pmk-3. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949251 – 657Tyrosine-protein phosphatase vhp-1Add BLAST657

Proteomic databases

EPDiQ10038
PaxDbiQ10038
PeptideAtlasiQ10038
PRIDEiQ10038

PTM databases

iPTMnetiQ10038

Expressioni

Tissue specificityi

Expressed in the pharynx, intestine, neurons and vulval hypodermal cells.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiWBGene00006923

Interactioni

Subunit structurei

May interact with pmk-3.1 Publication

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi39249, 1 interactor
DIPiDIP-59690N
IntActiQ10038, 1 interactor
STRINGi6239.F08B1.1a.3

Structurei

3D structure databases

ProteinModelPortaliQ10038
SMRiQ10038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 151RhodanesePROSITE-ProRule annotationAdd BLAST131
Domaini175 – 317Tyrosine-protein phosphataseAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi350 – 565Ser-richAdd BLAST216

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000017063
InParanoidiQ10038
OMAiCNAPEST
OrthoDBiEOG091G0249
PhylomeDBiQ10038

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 2 hits
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q10038-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS
60 70 80 90 100
KLIRRRLFEN KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK
110 120 130 140 150
RRIASCNAPE STAKIMRVLR ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC
160 170 180 190 200
ESSEGMTRLP QSLSQPCLSQ PTGDGITLIT PNIYLGSQID SLDETMLDAL
210 220 230 240 250
DISVVINLSM TCPKSVCIKE DKNFMRIPVN DSYQEKLSPY FPMAYEFLEK
260 270 280 290 300
CRRAGKKCLI HCLAGISRSP TLAISYIMRY MKMGSDDAYR YVKERRPSIS
310 320 330 340 350
PNFNFMGQLL EYENVLIKDH VLDYNQASRP HRHMDYYGPS DLCPPKVPKS
360 370 380 390 400
ASSNCVFPGS THDESSPSSP SVSEGSAASE PETSSSAASS SSTASAPPSM
410 420 430 440 450
PSTSEQGTSS GTVNVNGKRN MTMDLGLPHR PKALGLPSRI GTSVAELPSP
460 470 480 490 500
STELSRLSFN GPEAIAPSTP ILNFTNPCFN SPIIPVASSS REVILTLPTP
510 520 530 540 550
AASSSSSTSS EPSFDFSSFE SSSSSSIVVE NPFFASTEVP AGSSSISTPS
560 570 580 590 600
GSQSTPASAS SSAASRCRMK GFFKVFSKKA PASTSTPASS TPGTSRAARP
610 620 630 640 650
ECLRSSGIII SAPVLAITEE EDAESPESGF NEPEVGEEDD DSVSICSTSS

LEIPCHQ
Length:657
Mass (Da):71,003
Last modified:June 7, 2005 - v2
Checksum:iA0D9153DE6326B43
GO
Isoform b (identifier: Q10038-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: MTVLDTVTIS...DKFRSVMVLE → MGGQPFEAFR...SPISSSSPTN

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):64,963
Checksum:i5B71795C6ED58058
GO
Isoform c (identifier: Q10038-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     588-657: ASSTPGTSRA...TSSLEIPCHQ → VSIMKLH

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):46,893
Checksum:iA7FF64BDC46B0774
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140131 – 155Missing in isoform c. CuratedAdd BLAST155
Alternative sequenceiVSP_0140141 – 136MTVLD…VMVLE → MGGQPFEAFRKNRKRKKTKN KKKRRNNNNSKNKTPNTFPN EIEEQDPVSSLPTFPAKKFG LKLQLTLTSSPTNSSSPISS SSPTN in isoform b. CuratedAdd BLAST136
Alternative sequenceiVSP_014015588 – 657ASSTP…IPCHQ → VSIMKLH in isoform c. CuratedAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY585194 mRNA Translation: AAS91377.1
FO081082 Genomic DNA Translation: CCD68973.1
FO081082 Genomic DNA Translation: CCD68974.1
FO081082 Genomic DNA Translation: CCD68975.1
PIRiT15969
RefSeqiNP_494997.1, NM_062596.4 [Q10038-1]
NP_494998.1, NM_062597.1 [Q10038-2]
NP_871926.1, NM_182126.3
UniGeneiCel.8018

Genome annotation databases

EnsemblMetazoaiF08B1.1a.1; F08B1.1a.1; WBGene00006923 [Q10038-1]
F08B1.1a.2; F08B1.1a.2; WBGene00006923 [Q10038-1]
F08B1.1a.3; F08B1.1a.3; WBGene00006923 [Q10038-1]
GeneIDi173904
UCSCiF08B1.1a.3 c. elegans [Q10038-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVHP1_CAEEL
AccessioniPrimary (citable) accession number: Q10038
Secondary accession number(s): Q8IG35, Q8ST18, Q8ST19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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