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Protein

Putative diacylglycerol kinase K06A1.6

Gene

dgk-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB-EC
  3. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_304295. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative diacylglycerol kinase K06A1.6 (EC:2.7.1.107)
Short name:
DAG kinase
Alternative name(s):
Diglyceride kinase
Short name:
DGK
Gene namesi
Name:dgk-5
ORF Names:K06A1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK06A1.6; CE28048; WBGene00019428; dgk-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 937937Putative diacylglycerol kinase K06A1.6PRO_0000218472Add
BLAST

Proteomic databases

PaxDbiQ10024.
PRIDEiQ10024.

Interactioni

Protein-protein interaction databases

STRINGi6239.K06A1.6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini414 – 551138DAGKcPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 15763Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000016931.
InParanoidiQ10024.
KOiK00901.
OMAiNTDECLL.
OrthoDBiEOG76HQ0Q.
PhylomeDBiQ10024.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFPIGIPMI SKKRKSAQEA VSLREAAERR SQFARVPARS VSAPPRKKWF
60 70 80 90 100
RSKQQLSGAA DGMDGSSRAG SQEIVCDEFT KKLVAAITTW HDIHSSLLQL
110 120 130 140 150
SIERSSNDSN EEHENVSVSS ESSWSSASDS ESDEDSATGR DSTNNHLSAS
160 170 180 190 200
AARFSISNPD LTNCQIKQMF PEMADHWRKA LAKSPVVRRT AADQETSNPV
210 220 230 240 250
NKHRSSRYWI EDEGDYHILP SEHVWLPSST GSSASADSEC YVGEKDCRRS
260 270 280 290 300
GEKRRCAACH IVAHTNCFSL LAKLNLNCKT TFRDYATKKT PSKESTDGLT
310 320 330 340 350
AHHWVHKWRH EGRCNTCAKS FQQKMFFQGK EKKETIAVTC SWCKESYHLK
360 370 380 390 400
NCFARDKLEE RCNRGALKEM IVPPTWILRL ANRKRSSRTP SHPRKHKKSH
410 420 430 440 450
RQFVVKPTDL WSSGPSQPLL VFVNPKSGGN KGSKALHTLC WLLNPRQVFD
460 470 480 490 500
ITSLKGPKFG LEMFRKVVTQ LRILVCGGDG TVGWVLSTLD NLNWPAYPPM
510 520 530 540 550
AIMPLGTGND LARCMGWGGV FSDEPISQLM QAILHETIVT HLDRWRIDVE
560 570 580 590 600
PNTSCNLEEE DDGMQSALPL TVMTNYFSIG ADAHVALQFH HSRSANPQML
610 620 630 640 650
NSRLKNRIAY GGLGTIDLFK RSWKDLCEYI TLECDGVDVT PRIKELKLHC
660 670 680 690 700
ILFHNITYYA GGTIPWGESS DNKPSCCDGK VEVLGFTTAT LAALQMGGKG
710 720 730 740 750
ERIAQCSRVR VITNKAIPMQ VDGEPCLLAP SIITLGFHSK VPMLKREKKT
760 770 780 790 800
PCTPNLMRRG TRYGQKDSQV QSTSLIIQLP VIVVGRADYD NYKDCFERLK
810 820 830 840 850
DTAYEIGIVN VESEAELDSA RVLIQRLLVE HNSLPYEPDK NWRFLDYVSN
860 870 880 890 900
AEEGTFRVSR QQEHVQSVSD VCNTDECLLI LDHAFPSITD REAVELFQPQ
910 920 930
QPIPSTSTSA APRYHNSRRI SETLRIVLSS DAQETHL
Length:937
Mass (Da):105,198
Last modified:August 22, 2003 - v2
Checksum:i7F9FA163AF783790
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081583 Genomic DNA. Translation: CCD72614.1.
PIRiT16947.
T34334.
RefSeqiNP_495301.1. NM_062900.3.
UniGeneiCel.14796.

Genome annotation databases

EnsemblMetazoaiK06A1.6; K06A1.6; WBGene00019428.
GeneIDi174068.
KEGGicel:CELE_K06A1.6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081583 Genomic DNA. Translation: CCD72614.1.
PIRiT16947.
T34334.
RefSeqiNP_495301.1. NM_062900.3.
UniGeneiCel.14796.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K06A1.6.

Proteomic databases

PaxDbiQ10024.
PRIDEiQ10024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK06A1.6; K06A1.6; WBGene00019428.
GeneIDi174068.
KEGGicel:CELE_K06A1.6.

Organism-specific databases

CTDi174068.
WormBaseiK06A1.6; CE28048; WBGene00019428; dgk-5.

Phylogenomic databases

eggNOGiNOG47311.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000016931.
InParanoidiQ10024.
KOiK00901.
OMAiNTDECLL.
OrthoDBiEOG76HQ0Q.
PhylomeDBiQ10024.

Enzyme and pathway databases

ReactomeiREACT_304295. Effects of PIP2 hydrolysis.

Miscellaneous databases

NextBioi882363.
PROiQ10024.

Family and domain databases

InterProiIPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDGK5_CAEEL
AccessioniPrimary (citable) accession number: Q10024
Secondary accession number(s): Q09588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 22, 2003
Last modified: April 29, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.