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Q10024

- DGK5_CAEEL

UniProt

Q10024 - DGK5_CAEEL

Protein

Putative diacylglycerol kinase K06A1.6

Gene

dgk-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB-EC
    3. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative diacylglycerol kinase K06A1.6 (EC:2.7.1.107)
    Short name:
    DAG kinase
    Alternative name(s):
    Diglyceride kinase
    Short name:
    DGK
    Gene namesi
    Name:dgk-5
    ORF Names:K06A1.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiK06A1.6; CE28048; WBGene00019428; dgk-5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 937937Putative diacylglycerol kinase K06A1.6PRO_0000218472Add
    BLAST

    Proteomic databases

    PaxDbiQ10024.
    PRIDEiQ10024.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K06A1.6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10024.
    SMRiQ10024. Positions 219-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini414 – 551138DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 15763Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG47311.
    GeneTreeiENSGT00740000115137.
    HOGENOMiHOG000016931.
    InParanoidiQ10024.
    KOiK00901.
    OMAiNTDECLL.
    OrthoDBiEOG76HQ0Q.
    PhylomeDBiQ10024.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFPIGIPMI SKKRKSAQEA VSLREAAERR SQFARVPARS VSAPPRKKWF    50
    RSKQQLSGAA DGMDGSSRAG SQEIVCDEFT KKLVAAITTW HDIHSSLLQL 100
    SIERSSNDSN EEHENVSVSS ESSWSSASDS ESDEDSATGR DSTNNHLSAS 150
    AARFSISNPD LTNCQIKQMF PEMADHWRKA LAKSPVVRRT AADQETSNPV 200
    NKHRSSRYWI EDEGDYHILP SEHVWLPSST GSSASADSEC YVGEKDCRRS 250
    GEKRRCAACH IVAHTNCFSL LAKLNLNCKT TFRDYATKKT PSKESTDGLT 300
    AHHWVHKWRH EGRCNTCAKS FQQKMFFQGK EKKETIAVTC SWCKESYHLK 350
    NCFARDKLEE RCNRGALKEM IVPPTWILRL ANRKRSSRTP SHPRKHKKSH 400
    RQFVVKPTDL WSSGPSQPLL VFVNPKSGGN KGSKALHTLC WLLNPRQVFD 450
    ITSLKGPKFG LEMFRKVVTQ LRILVCGGDG TVGWVLSTLD NLNWPAYPPM 500
    AIMPLGTGND LARCMGWGGV FSDEPISQLM QAILHETIVT HLDRWRIDVE 550
    PNTSCNLEEE DDGMQSALPL TVMTNYFSIG ADAHVALQFH HSRSANPQML 600
    NSRLKNRIAY GGLGTIDLFK RSWKDLCEYI TLECDGVDVT PRIKELKLHC 650
    ILFHNITYYA GGTIPWGESS DNKPSCCDGK VEVLGFTTAT LAALQMGGKG 700
    ERIAQCSRVR VITNKAIPMQ VDGEPCLLAP SIITLGFHSK VPMLKREKKT 750
    PCTPNLMRRG TRYGQKDSQV QSTSLIIQLP VIVVGRADYD NYKDCFERLK 800
    DTAYEIGIVN VESEAELDSA RVLIQRLLVE HNSLPYEPDK NWRFLDYVSN 850
    AEEGTFRVSR QQEHVQSVSD VCNTDECLLI LDHAFPSITD REAVELFQPQ 900
    QPIPSTSTSA APRYHNSRRI SETLRIVLSS DAQETHL 937
    Length:937
    Mass (Da):105,198
    Last modified:August 22, 2003 - v2
    Checksum:i7F9FA163AF783790
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081583 Genomic DNA. Translation: CCD72614.1.
    PIRiT16947.
    T34334.
    RefSeqiNP_495301.1. NM_062900.3.
    UniGeneiCel.14796.

    Genome annotation databases

    EnsemblMetazoaiK06A1.6; K06A1.6; WBGene00019428.
    GeneIDi174068.
    KEGGicel:CELE_K06A1.6.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081583 Genomic DNA. Translation: CCD72614.1 .
    PIRi T16947.
    T34334.
    RefSeqi NP_495301.1. NM_062900.3.
    UniGenei Cel.14796.

    3D structure databases

    ProteinModelPortali Q10024.
    SMRi Q10024. Positions 219-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K06A1.6.

    Proteomic databases

    PaxDbi Q10024.
    PRIDEi Q10024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K06A1.6 ; K06A1.6 ; WBGene00019428 .
    GeneIDi 174068.
    KEGGi cel:CELE_K06A1.6.

    Organism-specific databases

    CTDi 174068.
    WormBasei K06A1.6 ; CE28048 ; WBGene00019428 ; dgk-5.

    Phylogenomic databases

    eggNOGi NOG47311.
    GeneTreei ENSGT00740000115137.
    HOGENOMi HOG000016931.
    InParanoidi Q10024.
    KOi K00901.
    OMAi NTDECLL.
    OrthoDBi EOG76HQ0Q.
    PhylomeDBi Q10024.

    Miscellaneous databases

    NextBioi 882363.
    PROi Q10024.

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiDGK5_CAEEL
    AccessioniPrimary (citable) accession number: Q10024
    Secondary accession number(s): Q09588
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3