Q10024 (DGK5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative diacylglycerol kinase K06A1.6
Short name=DAG kinase
EC=2.7.1.107

Alternative name(s):
Diglyceride kinase
Short name=DGK

Gene names

Name:	dgk-5
ORF Names:	K06A1.6

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	937 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
Sequence similarities	Belongs to the eukaryotic diacylglycerol kinase family. Contains 1 DAGKc domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 937	937	Putative diacylglycerol kinase K06A1.6		PRO_0000218472
Regions
	Domain	414 – 551	138	DAGKc
	Compositional bias	95 – 157	63	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q10024 [UniParc]. Last modified August 22, 2003. Version 2. Checksum: 7F9FA163AF783790	FASTA	937	105,198
	10 20 30 40 50 60 MIFPIGIPMI SKKRKSAQEA VSLREAAERR SQFARVPARS VSAPPRKKWF RSKQQLSGAA 70 80 90 100 110 120 DGMDGSSRAG SQEIVCDEFT KKLVAAITTW HDIHSSLLQL SIERSSNDSN EEHENVSVSS 130 140 150 160 170 180 ESSWSSASDS ESDEDSATGR DSTNNHLSAS AARFSISNPD LTNCQIKQMF PEMADHWRKA 190 200 210 220 230 240 LAKSPVVRRT AADQETSNPV NKHRSSRYWI EDEGDYHILP SEHVWLPSST GSSASADSEC 250 260 270 280 290 300 YVGEKDCRRS GEKRRCAACH IVAHTNCFSL LAKLNLNCKT TFRDYATKKT PSKESTDGLT 310 320 330 340 350 360 AHHWVHKWRH EGRCNTCAKS FQQKMFFQGK EKKETIAVTC SWCKESYHLK NCFARDKLEE 370 380 390 400 410 420 RCNRGALKEM IVPPTWILRL ANRKRSSRTP SHPRKHKKSH RQFVVKPTDL WSSGPSQPLL 430 440 450 460 470 480 VFVNPKSGGN KGSKALHTLC WLLNPRQVFD ITSLKGPKFG LEMFRKVVTQ LRILVCGGDG 490 500 510 520 530 540 TVGWVLSTLD NLNWPAYPPM AIMPLGTGND LARCMGWGGV FSDEPISQLM QAILHETIVT 550 560 570 580 590 600 HLDRWRIDVE PNTSCNLEEE DDGMQSALPL TVMTNYFSIG ADAHVALQFH HSRSANPQML 610 620 630 640 650 660 NSRLKNRIAY GGLGTIDLFK RSWKDLCEYI TLECDGVDVT PRIKELKLHC ILFHNITYYA 670 680 690 700 710 720 GGTIPWGESS DNKPSCCDGK VEVLGFTTAT LAALQMGGKG ERIAQCSRVR VITNKAIPMQ 730 740 750 760 770 780 VDGEPCLLAP SIITLGFHSK VPMLKREKKT PCTPNLMRRG TRYGQKDSQV QSTSLIIQLP 790 800 810 820 830 840 VIVVGRADYD NYKDCFERLK DTAYEIGIVN VESEAELDSA RVLIQRLLVE HNSLPYEPDK 850 860 870 880 890 900 NWRFLDYVSN AEEGTFRVSR QQEHVQSVSD VCNTDECLLI LDHAFPSITD REAVELFQPQ 910 920 930 QPIPSTSTSA APRYHNSRRI SETLRIVLSS DAQETHL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081583 Genomic DNA. Translation: CCD72614.1.
PIR	T16947. T34334.
RefSeq	NP_495301.1. NM_062900.2.
UniGene	Cel.14796.
3D structure databases
ProteinModelPortal	Q10024.
ModBase	Search...
Protein-protein interaction databases
STRING	Q10024.
Proteomic databases
PRIDE	Q10024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K06A1.6; K06A1.6; K06A1.6.
GeneID	174068.
KEGG	cel:K06A1.6.
NMPDR	fig|6239.3.peg.5903.
Organism-specific databases
CTD	174068.
WormBase	K06A1.6; CE28048; WBGene00019428; dgk-5.
Phylogenomic databases
eggNOG	meNOG04953.
GeneTree	EMGT00050000007391.
HOGENOM	HBG445843.
InParanoid	Q10024.
OMA	NTDECLL.
PhylomeDB	Q10024.
Gene expression databases
ArrayExpress	Q10024.
Family and domain databases
InterPro	IPR000756. Diacylglycerol_kin_accessory. IPR001206. Diacylglycerol_kinase_cat_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. [Graphical view]
KO	K00901.
Pfam	PF00130. C1_1. 1 hit. PF00609. DAGK_acc. 1 hit. PF00781. DAGK_cat. 1 hit. [Graphical view]
SMART	SM00045. DAGKa. 1 hit. SM00046. DAGKc. 1 hit. [Graphical view]
PROSITE	PS50146. DAGK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	882363.

Entry information

Entry name

DGK5_CAEEL

Accession

Primary (citable) accession number: Q10024
Secondary accession number(s): Q09588

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 22, 2003
Last modified:	December 14, 2011
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project