ID   KLRB1_MOUSE             Reviewed;         214 AA.
AC   Q0ZUP1; Q1A4F6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   24-JAN-2024, entry version 101.
DE   RecName: Full=Killer cell lectin-like receptor subfamily B member 1;
DE   AltName: Full=Killer cell lectin-like receptor subfamily B member 1G;
DE   AltName: Full=Natural killer cell surface protein NKR-P1G;
DE   AltName: Full=Natural killer lectin-like receptor 1E;
GN   Name=Klrb1;
GN   Synonyms=Gm4696, Klrb1d, Klrb1g, Klrb6 {ECO:0000312|EMBL:ABA41355.1},
GN   Nkrp1g {ECO:0000312|EMBL:ABC71751.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:ABA41355.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:ABA41355.1};
RA   Fossum S., Flornes L.M., Saether P.C., Dissen E.;
RT   "Gene homogenization of exons encoding the ligand binding parts of
RT   regulatory leukocyte receptors.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:ABC71751.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-174.
RC   STRAIN=BALB/cJ {ECO:0000312|EMBL:ABC71751.1};
RX   PubMed=16751398; DOI=10.4049/jimmunol.176.12.7511;
RA   Carlyle J.R., Mesci A., Ljutic B., Belanger S., Tai L.-H., Rousselle E.,
RA   Troke A.D., Proteau M.-F., Makrigiannis A.P.;
RT   "Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of
RT   mouse NK cells.";
RL   J. Immunol. 176:7511-7524(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type II
CC       membrane protein {ECO:0000255}.
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DR   EMBL; DQ113419; ABA41355.1; -; mRNA.
DR   EMBL; DQ336141; ABC71751.1; -; Genomic_DNA.
DR   CCDS; CCDS39653.1; -.
DR   RefSeq; NP_001093388.1; NM_001099918.1.
DR   AlphaFoldDB; Q0ZUP1; -.
DR   SMR; Q0ZUP1; -.
DR   STRING; 10090.ENSMUSP00000107738; -.
DR   PaxDb; 10090-ENSMUSP00000107738; -.
DR   DNASU; 100043861; -.
DR   Ensembl; ENSMUST00000112110.4; ENSMUSP00000107738.3; ENSMUSG00000079299.4.
DR   GeneID; 100043861; -.
DR   KEGG; mmu:100043861; -.
DR   UCSC; uc009eem.1; mouse.
DR   AGR; MGI:96877; -.
DR   CTD; 3820; -.
DR   MGI; MGI:96877; Klrb1.
DR   VEuPathDB; HostDB:ENSMUSG00000079299; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00940000154685; -.
DR   HOGENOM; CLU_049894_8_2_1; -.
DR   InParanoid; Q0ZUP1; -.
DR   OMA; WHRVALK; -.
DR   OrthoDB; 4828219at2759; -.
DR   PhylomeDB; Q0ZUP1; -.
DR   TreeFam; TF337735; -.
DR   BioGRID-ORCS; 100043861; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Klrb1b; mouse.
DR   PRO; PR:Q0ZUP1; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q0ZUP1; Protein.
DR   Bgee; ENSMUSG00000079299; Expressed in animal zygote and 25 other cell types or tissues.
DR   ExpressionAtlas; Q0ZUP1; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IDA:MGI.
DR   GO; GO:0042269; P:regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   PANTHER; PTHR46784; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1; 1.
DR   PANTHER; PTHR46784:SF2; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Lectin; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..214
FT                   /note="Killer cell lectin-like receptor subfamily B member
FT                   1"
FT                   /id="PRO_0000317213"
FT   TOPO_DOM        1..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..214
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          98..208
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        119..207
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        186..199
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   214 AA;  23909 MW;  79DEC281E49943DF CRC64;
     MDAPVLYAEL NLAETRGLRC TSAPSLPQDA CQGPGWHRVA LKLGCAGLIF LLMVLSVLVG
     FLVQKPLIEK CSVAVQENRT EPTGRSATLE CPRDWHPHCD KCLFTSQTSR PWADGLVDCN
     LKGATLLLIQ DEEELRLLQN FSKGKGQQFY IGLKYEEVDK VWKWMNGSIL NTNLLQITGK
     DEENSCALIS QTEVFSDSCS SDNHWICQKT LKHV
//