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Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

Klrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1
Alternative name(s):
Killer cell lectin-like receptor subfamily B member 1G
Natural killer cell surface protein NKR-P1G
Natural killer lectin-like receptor 1E
Gene namesi
Name:Klrb1
Synonyms:Gm4696, Klrb1d, Klrb1g, Klrb6Imported, Nkrp1gImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96877. Klrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini64 – 214151ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Killer cell lectin-like receptor subfamily B member 1PRO_0000317213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 207PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ0ZUP1.

Expressioni

Gene expression databases

BgeeiQ0ZUP1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107738.

Structurei

3D structure databases

ProteinModelPortaliQ0ZUP1.
SMRiQ0ZUP1. Positions 89-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 208111C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307083.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ0ZUP1.
KOiK06543.
OMAiWHRVALK.
OrthoDBiEOG7J4487.
PhylomeDBiQ0ZUP1.
TreeFamiTF337735.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ZUP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPVLYAEL NLAETRGLRC TSAPSLPQDA CQGPGWHRVA LKLGCAGLIF
60 70 80 90 100
LLMVLSVLVG FLVQKPLIEK CSVAVQENRT EPTGRSATLE CPRDWHPHCD
110 120 130 140 150
KCLFTSQTSR PWADGLVDCN LKGATLLLIQ DEEELRLLQN FSKGKGQQFY
160 170 180 190 200
IGLKYEEVDK VWKWMNGSIL NTNLLQITGK DEENSCALIS QTEVFSDSCS
210
SDNHWICQKT LKHV
Length:214
Mass (Da):23,909
Last modified:August 22, 2006 - v1
Checksum:i79DEC281E49943DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ113419 mRNA. Translation: ABA41355.1.
DQ336141 Genomic DNA. Translation: ABC71751.1.
CCDSiCCDS39653.1.
RefSeqiNP_001093388.1. NM_001099918.1.
UniGeneiMm.66911.

Genome annotation databases

EnsembliENSMUST00000112110; ENSMUSP00000107738; ENSMUSG00000079299.
GeneIDi100043861.
KEGGimmu:100043861.
UCSCiuc009eem.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ113419 mRNA. Translation: ABA41355.1.
DQ336141 Genomic DNA. Translation: ABC71751.1.
CCDSiCCDS39653.1.
RefSeqiNP_001093388.1. NM_001099918.1.
UniGeneiMm.66911.

3D structure databases

ProteinModelPortaliQ0ZUP1.
SMRiQ0ZUP1. Positions 89-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107738.

Proteomic databases

PRIDEiQ0ZUP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112110; ENSMUSP00000107738; ENSMUSG00000079299.
GeneIDi100043861.
KEGGimmu:100043861.
UCSCiuc009eem.1. mouse.

Organism-specific databases

CTDi3820.
MGIiMGI:96877. Klrb1.

Phylogenomic databases

eggNOGiNOG307083.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ0ZUP1.
KOiK06543.
OMAiWHRVALK.
OrthoDBiEOG7J4487.
PhylomeDBiQ0ZUP1.
TreeFamiTF337735.

Miscellaneous databases

NextBioi457273.
PROiQ0ZUP1.
SOURCEiSearch...

Gene expression databases

BgeeiQ0ZUP1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene homogenization of exons encoding the ligand binding parts of regulatory leukocyte receptors."
    Fossum S., Flornes L.M., Saether P.C., Dissen E.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6Imported.
  2. "Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells."
    Carlyle J.R., Mesci A., Ljutic B., Belanger S., Tai L.-H., Rousselle E., Troke A.D., Proteau M.-F., Makrigiannis A.P.
    J. Immunol. 176:7511-7524(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-174.
    Strain: BALB/cImported.

Entry informationi

Entry nameiKLRB1_MOUSE
AccessioniPrimary (citable) accession number: Q0ZUP1
Secondary accession number(s): Q1A4F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.