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Q0ZUP1

- KLRB1_MOUSE

UniProt

Q0ZUP1 - KLRB1_MOUSE

Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

Klrb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. protein binding Source: MGI
    3. receptor activity Source: MGI

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell lectin-like receptor subfamily B member 1
    Alternative name(s):
    Killer cell lectin-like receptor subfamily B member 1G
    Natural killer cell surface protein NKR-P1G
    Natural killer lectin-like receptor 1E
    Gene namesi
    Name:Klrb1
    Synonyms:Gm4696, Klrb1d, Klrb1g, Klrb6Imported, Nkrp1gImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96877. Klrb1.

    Subcellular locationi

    Membrane Sequence Analysis; Single-pass type II membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Killer cell lectin-like receptor subfamily B member 1PRO_0000317213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi119 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 199PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ0ZUP1.

    Expressioni

    Gene expression databases

    BgeeiQ0ZUP1.
    GenevestigatoriQ0ZUP1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000107738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0ZUP1.
    SMRiQ0ZUP1. Positions 89-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 214151ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini98 – 208111C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307083.
    GeneTreeiENSGT00730000110837.
    HOGENOMiHOG000074586.
    HOVERGENiHBG052267.
    InParanoidiQ0ZUP1.
    KOiK06543.
    OMAiWHRVALK.
    OrthoDBiEOG7J4487.
    PhylomeDBiQ0ZUP1.
    TreeFamiTF337735.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0ZUP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAPVLYAEL NLAETRGLRC TSAPSLPQDA CQGPGWHRVA LKLGCAGLIF    50
    LLMVLSVLVG FLVQKPLIEK CSVAVQENRT EPTGRSATLE CPRDWHPHCD 100
    KCLFTSQTSR PWADGLVDCN LKGATLLLIQ DEEELRLLQN FSKGKGQQFY 150
    IGLKYEEVDK VWKWMNGSIL NTNLLQITGK DEENSCALIS QTEVFSDSCS 200
    SDNHWICQKT LKHV 214
    Length:214
    Mass (Da):23,909
    Last modified:August 22, 2006 - v1
    Checksum:i79DEC281E49943DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113419 mRNA. Translation: ABA41355.1.
    DQ336141 Genomic DNA. Translation: ABC71751.1.
    CCDSiCCDS39653.1.
    RefSeqiNP_001093388.1. NM_001099918.1.
    UniGeneiMm.66911.

    Genome annotation databases

    EnsembliENSMUST00000112110; ENSMUSP00000107738; ENSMUSG00000079299.
    GeneIDi100043861.
    KEGGimmu:100043861.
    UCSCiuc009eem.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ113419 mRNA. Translation: ABA41355.1 .
    DQ336141 Genomic DNA. Translation: ABC71751.1 .
    CCDSi CCDS39653.1.
    RefSeqi NP_001093388.1. NM_001099918.1.
    UniGenei Mm.66911.

    3D structure databases

    ProteinModelPortali Q0ZUP1.
    SMRi Q0ZUP1. Positions 89-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000107738.

    Proteomic databases

    PRIDEi Q0ZUP1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112110 ; ENSMUSP00000107738 ; ENSMUSG00000079299 .
    GeneIDi 100043861.
    KEGGi mmu:100043861.
    UCSCi uc009eem.1. mouse.

    Organism-specific databases

    CTDi 3820.
    MGIi MGI:96877. Klrb1.

    Phylogenomic databases

    eggNOGi NOG307083.
    GeneTreei ENSGT00730000110837.
    HOGENOMi HOG000074586.
    HOVERGENi HBG052267.
    InParanoidi Q0ZUP1.
    KOi K06543.
    OMAi WHRVALK.
    OrthoDBi EOG7J4487.
    PhylomeDBi Q0ZUP1.
    TreeFami TF337735.

    Miscellaneous databases

    NextBioi 457273.
    PROi Q0ZUP1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q0ZUP1.
    Genevestigatori Q0ZUP1.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene homogenization of exons encoding the ligand binding parts of regulatory leukocyte receptors."
      Fossum S., Flornes L.M., Saether P.C., Dissen E.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6Imported.
    2. "Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells."
      Carlyle J.R., Mesci A., Ljutic B., Belanger S., Tai L.-H., Rousselle E., Troke A.D., Proteau M.-F., Makrigiannis A.P.
      J. Immunol. 176:7511-7524(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-174.
      Strain: BALB/cImported.

    Entry informationi

    Entry nameiKLRB1_MOUSE
    AccessioniPrimary (citable) accession number: Q0ZUP1
    Secondary accession number(s): Q1A4F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3