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Q0ZUP1

- KLRB1_MOUSE

UniProt

Q0ZUP1 - KLRB1_MOUSE

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Protein

Killer cell lectin-like receptor subfamily B member 1

Gene
Klrb1, Gm4696, Klrb1d, Klrb1g, Klrb6, Nkrp1g
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. protein binding Source: MGI
  3. receptor activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1
Alternative name(s):
Killer cell lectin-like receptor subfamily B member 1G
Natural killer cell surface protein NKR-P1G
Natural killer lectin-like receptor 1E
Gene namesi
Name:Klrb1
Synonyms:Gm4696, Klrb1d, Klrb1g, Klrb6, Nkrp1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96877. Klrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini64 – 214151Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Killer cell lectin-like receptor subfamily B member 1PRO_0000317213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 207 By similarity
Disulfide bondi186 ↔ 199 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ0ZUP1.

Expressioni

Gene expression databases

BgeeiQ0ZUP1.
GenevestigatoriQ0ZUP1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107738.

Structurei

3D structure databases

ProteinModelPortaliQ0ZUP1.
SMRiQ0ZUP1. Positions 89-211.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 208111C-type lectinAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307083.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ0ZUP1.
KOiK06543.
OMAiWHRVALK.
OrthoDBiEOG7J4487.
PhylomeDBiQ0ZUP1.
TreeFamiTF337735.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ZUP1-1 [UniParc]FASTAAdd to Basket

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MDAPVLYAEL NLAETRGLRC TSAPSLPQDA CQGPGWHRVA LKLGCAGLIF    50
LLMVLSVLVG FLVQKPLIEK CSVAVQENRT EPTGRSATLE CPRDWHPHCD 100
KCLFTSQTSR PWADGLVDCN LKGATLLLIQ DEEELRLLQN FSKGKGQQFY 150
IGLKYEEVDK VWKWMNGSIL NTNLLQITGK DEENSCALIS QTEVFSDSCS 200
SDNHWICQKT LKHV 214
Length:214
Mass (Da):23,909
Last modified:August 22, 2006 - v1
Checksum:i79DEC281E49943DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ113419 mRNA. Translation: ABA41355.1.
DQ336141 Genomic DNA. Translation: ABC71751.1.
CCDSiCCDS39653.1.
RefSeqiNP_001093388.1. NM_001099918.1.
UniGeneiMm.66911.

Genome annotation databases

EnsembliENSMUST00000112110; ENSMUSP00000107738; ENSMUSG00000079299.
GeneIDi100043861.
KEGGimmu:100043861.
UCSCiuc009eem.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ113419 mRNA. Translation: ABA41355.1 .
DQ336141 Genomic DNA. Translation: ABC71751.1 .
CCDSi CCDS39653.1.
RefSeqi NP_001093388.1. NM_001099918.1.
UniGenei Mm.66911.

3D structure databases

ProteinModelPortali Q0ZUP1.
SMRi Q0ZUP1. Positions 89-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000107738.

Proteomic databases

PRIDEi Q0ZUP1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112110 ; ENSMUSP00000107738 ; ENSMUSG00000079299 .
GeneIDi 100043861.
KEGGi mmu:100043861.
UCSCi uc009eem.1. mouse.

Organism-specific databases

CTDi 3820.
MGIi MGI:96877. Klrb1.

Phylogenomic databases

eggNOGi NOG307083.
GeneTreei ENSGT00730000110837.
HOGENOMi HOG000074586.
HOVERGENi HBG052267.
InParanoidi Q0ZUP1.
KOi K06543.
OMAi WHRVALK.
OrthoDBi EOG7J4487.
PhylomeDBi Q0ZUP1.
TreeFami TF337735.

Miscellaneous databases

NextBioi 457273.
PROi Q0ZUP1.
SOURCEi Search...

Gene expression databases

Bgeei Q0ZUP1.
Genevestigatori Q0ZUP1.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene homogenization of exons encoding the ligand binding parts of regulatory leukocyte receptors."
    Fossum S., Flornes L.M., Saether P.C., Dissen E.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells."
    Carlyle J.R., Mesci A., Ljutic B., Belanger S., Tai L.-H., Rousselle E., Troke A.D., Proteau M.-F., Makrigiannis A.P.
    J. Immunol. 176:7511-7524(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-174.
    Strain: BALB/c.

Entry informationi

Entry nameiKLRB1_MOUSE
AccessioniPrimary (citable) accession number: Q0ZUP1
Secondary accession number(s): Q1A4F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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