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Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

Klrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1
Alternative name(s):
Immunoreceptor NKR-P1E
Killer cell lectin-like receptor subfamily B member 1G
Natural killer cell surface protein NKR-P1G
Natural killer lectin-like receptor 1E
Gene namesi
Name:Klrb1
Synonyms:Klrb1dImported, Klrb1g, Klrb6Imported, Nkrp1eImported, Nkrp1g1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1587563. Klrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini64 – 214151ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Killer cell lectin-like receptor subfamily B member 1PRO_0000317214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 207PROSITE-ProRule annotation
Disulfide bondi186 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ0ZUP0.
PRIDEiQ0ZUP0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036493.

Structurei

3D structure databases

ProteinModelPortaliQ0ZUP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 208111C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ0ZUP0.
KOiK06543.
OMAiWHRVALK.
OrthoDBiEOG7J4487.
PhylomeDBiQ0ZUP0.
TreeFamiTF337735.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ZUP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPVLYAEL HLANTQGLRC TSPPSPRQDA CWGSGWHRVA LKLGCVGLIL
60 70 80 90 100
LLMGLSVLVG FLVQKPPIEK CSVAVQENKT EPTVRSTILE CPRDWHLHWN
110 120 130 140 150
KCLFISQTSR PWAEGLADCS LRGATLLLIG DGKELKLLQD FSKGKGQQFF
160 170 180 190 200
IGLKYVQEDK VWKWMNGSIL NTNLLRITGK NEENSCALIS HTEVFSDSCS
210
SDNHWICQKT LKRV
Length:214
Mass (Da):23,963
Last modified:August 22, 2006 - v1
Checksum:iCE2AC7D1C9417D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157011 mRNA. Translation: ABA40405.1.
DQ157012 mRNA. Translation: ABA40406.1.
DQ113420 mRNA. Translation: ABA41356.1.
EF100680 mRNA. Translation: ABO15820.1.
RefSeqiNP_001078874.1. NM_001085405.1.
UniGeneiRn.198693.

Genome annotation databases

EnsembliENSRNOT00000084289; ENSRNOP00000072670; ENSRNOG00000057410.
GeneIDi689817.
KEGGirno:689817.
UCSCiRGD:1587563. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157011 mRNA. Translation: ABA40405.1.
DQ157012 mRNA. Translation: ABA40406.1.
DQ113420 mRNA. Translation: ABA41356.1.
EF100680 mRNA. Translation: ABO15820.1.
RefSeqiNP_001078874.1. NM_001085405.1.
UniGeneiRn.198693.

3D structure databases

ProteinModelPortaliQ0ZUP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036493.

Proteomic databases

PaxDbiQ0ZUP0.
PRIDEiQ0ZUP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084289; ENSRNOP00000072670; ENSRNOG00000057410.
GeneIDi689817.
KEGGirno:689817.
UCSCiRGD:1587563. rat.

Organism-specific databases

CTDi3820.
RGDi1587563. Klrb1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00730000110837.
HOGENOMiHOG000074586.
HOVERGENiHBG052267.
InParanoidiQ0ZUP0.
KOiK06543.
OMAiWHRVALK.
OrthoDBiEOG7J4487.
PhylomeDBiQ0ZUP0.
TreeFamiTF337735.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

NextBioi739539.
PROiQ0ZUP0.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Ocil/Clr-b missing-self axis."
    Voigt S., Mesci A., Ettinger J., Fine J.H., Chen P., Chou W., Carlyle J.R.
    Immunity 26:617-627(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WAGImported.
    Tissue: SpleenImported.
  2. "Gene homogenization of exons encoding the ligand binding parts of regulatory leukocyte receptors."
    Fossum S., Flornes L.M., Saether P.C., Dissen E.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: PVGImported.
  3. "Novel NKR-P1E receptor expressed by rat NK cells."
    Dai K.-Z., Naper C., Vaage J.T.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DAImported and PVGImported.

Entry informationi

Entry nameiKLRB1_RAT
AccessioniPrimary (citable) accession number: Q0ZUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 22, 2006
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.